I think that the mental aspect is the biggest problem with younger users, most people when they are young are'nt mature enough to handle the emotional ups and downs, and sometimes just do some down right stupid shit. As far as the physical damage goes, there are cause and effects for everything...
High systole means that your heart is contracting very hard to pump the blood through your circ system, which means more stress on your heart, arteries, and so on, and your diastolic pressure is your heart at rest.
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