Heres a post from Jguns on Tren and fat burining:
We have all heard about how Tren supposedly has magic fat burning capabilities, but have been with very little information as to how this supposedly takes place.
One of the biggest factors is the Androgen Receptor. Specifically, an Anabolic Steroids ability to bind to the AR plays a role in how much adipose tissue is reduced.
Most androgens interact with the AR and the GR (glucocortisoid receptor). The AR is present in not only muscle tissue, but in fat as well.
“In conclusion, this study clearly demonstrates the presence of AR in human preadipocytes and adipocytes and suggests that androgens may contribute, through regulation of their own receptors, to the control of adipose tissue development.”
Androgen receptors in human preadipocytes and adipocytes: regional specificities and regulation by sex steroids.
Am J Physiol. 1998 Jun;274(6 Pt 1):C1645-52.
This next study shows that the more AR’s , the more lipid uptake is inhibited:
Androgen hormone binding to adipose tissue in rats.
Biochim Biophys Acta. 1995 May 11;1244(1):117-20.
The first study shows that the more affinity and androgen has for the AR the more the AR in adipocytes upregulates. Theus the greater the Anabolic Androgenic Steroids (AAS) binds to the AR, the more upregulation of AR in adipcytes occurs (my leap). This would be a primary reason why tren seems to work so well in this regard, and would lead to a significant reduction in sub cutaneous adipose tissue.
Another reason that tren and other Anabolic Androgenic Steroids (AAS) that bind tightly to the AR could help with fat loss is that that decrease LPL lipoprotein lipasel) which is an enzyme that causes lipid accumulation
The effects of androgens on the regulation of lipolysis in adipose precursor cells.
Endocrinology. 1990 Feb;126(2):1229-34.
They may also decrease acetyl-CoA Carboxylase and Fatty Acid Sythetase
Effect of anabolic steroids on lipogenic and lipolytic enzymes in sheep tissues.
Horm Metab Res. 1982 Jan;14(1):52-3.
As for how the GR comes into play: The binding of cortisol to the GR can cause an increase in LPL. Thus, certain androgens may prevent lipid accumulation by binding to the GR.
Characterization of regional and gender differences in glucocorticoid receptors and lipoprotein lipase activity in human adipose tissue.
J Clin Endocrinol Metab. 1994 Jun;78(6):1354-9.
The effects of cortisol on the regulation of lipoprotein lipase activity in human adipose tissue.
J Clin Endocrinol Metab. 1994 Sep;79(3):820-5.
Effects of physiological hypercortisolemia on the regulation of lipolysis in subcutaneous adipose tissue.
J Clin Endocrinol Metab. 1998 Feb;83(2):626-31.
Studies have shown that Tren binds to the AR even more tightly then test or nandrolone, so this is one reason why tren is good at fat loss. The thing that makes it unique is that it has been shown to bind avidly to the GR as well, which makes it even better.
Binding of glucocorticoid antagonists to androgen and glucocorticoid hormone receptors in rat skeletal muscle.
J Steroid Biochem. 1986 Feb;24(2):481-7
Evidence for sex-dependent anabolic response to androgenic steroids mediated by muscle glucocorticoid receptors in the rat.
J Steroid Biochem. 1988 Jun;29(6):575-81
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