Arimidex and Estrogen Reduction Answered

StoneColdNTO

Administrator
I have seen way to many posts where guys are saying that even small dosages of Arimidex/Anastrozole will reduce Estrogen too much.

This is a common misconception that just keeps getting repeated over and over.

Here is a real study for your consideration;

Estrogen Suppression in Males: Metabolic Effects -- Mauras et al. 85 (7): 2370 -- Journal of Clinical Endocrinology & Metabolism

Estrogen Suppression in Males: Metabolic Effects1

Nelly Mauras, Kimberly O. O’Brien, Karen Oerter Klein and Valerie Hayes
Nemours Research Programs at the Nemours Children’s Clinic (N.M., V..H.), Jacksonville, Florida 32207; DuPont Hospital for Children (K.O.K.), Wilmington, Delaware 19803; and The Johns Hopkins University School of Hygiene and Public Health (K.O.O.), Baltimore, Maryland 21205-2179

Address all correspondence and requests for reprints to: Nelly Mauras, M.D., Nemours Children’s Clinic, 807 Nira Street, Jacksonville, Florida 32207. E-mail: nmauras@nemours.org.

We have shown that testosterone (T) deficiency per se is associated with marked catabolic effects on protein, calcium metabolism, and body composition in men independent of changes in GH or insulin-like growth factor I production. It is not clear, however, whether estrogens have a major role in whole body anabolism in males. We investigated the metabolic effects of selective estrogen suppression in the male using a potent aromatase inhibitor, Arimidex (Anastrozole). First, a dose-response study of 12 males (mean age, 16.1 ± 0.3 yr) was conducted, and blood withdrawn at baseline and after 10 days of oral Arimidex given as two different doses (either 0.5 or 1 mg) in random order with a 14-day washout in between. A sensitive estradiol (E2) assay showed an approximately 50% decrease in E2 concentrations with either of the two doses; hence, a 1-mg dose was selected for other studies. Subsequently, eight males (aged 15–22 yr; four adults and four late pubertal) had isotopic infusions of [13C]leucine and 42Ca/44Ca, indirect calorimetry, dual energy x-ray absorptiometry, isokinetic dynamometry, and growth factors measurements performed before and after 10 weeks of daily doses of Arimidex. Contrary to the effects of T withdrawal, there were no significant changes in body composition (body mass index, fat mass, and fat-free mass) after estrogen suppression or in rates of protein synthesis or degradation; carbohydrate, lipid, or protein oxidation; muscle strength; calcium kinetics; or bone growth factors concentrations. However, E2 concentrations decreased 48% (P = 0.006), with no significant change in mean and peak GH concentrations, but with an 18% decrease in plasma insulin-like growth factor I concentrations. There was a 58% increase in serum T (P = 0.0001), sex hormone-binding globulin did not change, whereas LH and FSH concentrations increased (P < 0.02, both). Serum bone markers, osteocalcin and bone alkaline phosphatase concentrations, and rates of bone calcium deposition and resorption did not change. In conclusion, these data suggest that in the male 1) estrogens do not contribute significantly to the changes in body composition and protein synthesis observed with changing androgen levels; 2) estrogen is a main regulator of the gonadal-pituitary feedback for the gonadotropin axis; and 3) this level of aromatase inhibition does not negatively impact either kinetically measured rates of bone calcium turnover or indirect markers of bone calcium turnover, at least in the short term. Further studies will provide valuable information on whether timed aromatase inhibition can be useful in increasing the height potential of pubertal boys with profound growth retardation without the confounding negative effects of gonadal androgen suppression.
 
thanks for the info stone, But how much exactly do you want to block for Aromatase inhibitor (AI) purpose?

A certain amount, not all of it. Estrogen is needed in some amounts to function, well, regularly, I guess.

Letro apparently blocks nearly ALL estrogen, that's why arimidex is better for some guys. Low estrogen can inhibit gains, lower libido and dry out your joints.
 
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