<H1>AVINZA</H1><P>AVINZA consists of two components, an immediate release component that rapidly
achieves plateau morphine plasma concentrations and an extended release component
that maintains plasma concentrations throughout the 24-hour dosing interval. The
amount of morphine absorbed from AVINZA following oral administration is similar to that
absorbed from other oral morphine formulations.
The oral bioavailability of morphine is less than 40% and shows large inter-individual
variability due to extensive pre-systemic metabolism.</P>
achieves plateau morphine plasma concentrations and an extended release component
that maintains plasma concentrations throughout the 24-hour dosing interval. The
amount of morphine absorbed from AVINZA following oral administration is similar to that
absorbed from other oral morphine formulations.
The oral bioavailability of morphine is less than 40% and shows large inter-individual
variability due to extensive pre-systemic metabolism.</P>
