Some people use the .22 for tren conversions after a pass with the .45 to get rid of some more of those devilish "binders and fillers". Personally, i dont think theres a way any binder material could make it through the .45. Plus, seeing as how they arent the cause of "tren cough" whats the difference if you have a little in solution? Darker color after baking is about the only difference I can think of.