I've used straight Yohimbine before and yes I do find it works well for targeting those stubborn areas in the lower body. The only thing that I don't like about it is the "cold sweats" that come along with it's usage. If you are doing the ECA stack, Yohimbine is great to take on your off days from the stack. It acts as sort of a thermogenic extender. I've heard lots of great stuff about Yohimburn, though I must admit I've never tried it. It's a topical Yohimbine solution.