How pharma makes rHGH , high tech

[anzel]

Protein Secretion Technology
As of 2010, a newer technology is used to manufacture most currently available rHGHs on the market. It is referred to as protein secretion technology, and its major advantage is that rHGH is secreted from E. coli and does not accumulate in inclusion bodies. This process allows for easier purification of rHGH and the production of rHGH that is identical to human growth hormone.

Mouse-Cell Technology
Producing rHGH using mouse-cell technology involves insertion of the DNA that encodes for human growth hormone into the DNA in mouse cells. The protein is produced in mouse cells instead of E. coli bacteria in the laboratory. Although more costly initially, this process produces rHGH that requires less manipulation and purification. This technology also produces rHGH that is identical to human growth hormone.

Not something any UGL can do, thats for sure.

 

[China_Wall]

UGL's do not manufacturer rHGH... every single one of them buys it from the source in China with whatever color top or label they want

These manufacturers in China make the so-called pharm grade and every other grade

 

[anzel]

That is correct.
Who knows if the ugl is even buying from a legit source themselves.

 

[Moppy1]

IGF-1 requires the same recombinant technology as is used to make HGH, so essentially all IGF-1 generated by peptide companies is inactive (R3 or otherwise).

It is all made in modified bacteria (E.coli) that have been modified with human enzymes to generate the correct linkage between the 2 chains, which ensures it is folded correctly and active (HGH and IGF-1 included, even insulin)

 

[juced_porkchop]

Protein Secretion Technology
As of 2010, a newer technology is used to manufacture most currently available rHGHs on the market. It is referred to as protein secretion technology, and its major advantage is that rHGH is secreted from E. coli and does not accumulate in inclusion bodies. This process allows for easier purification of rHGH and the production of rHGH that is identical to human growth hormone.

Mouse-Cell Technology
Producing rHGH using mouse-cell technology involves insertion of the DNA that encodes for human growth hormone into the DNA in mouse cells. The protein is produced in mouse cells instead of E. coli bacteria in the laboratory. Although more costly initially, this process produces rHGH that requires less manipulation and purification. This technology also produces rHGH that is identical to human growth hormone.

Not something any UGL can do, thats for sure.

personally I would call the first one Recombinant DNA technology> Recombinant DNA - Wikipedia, the free encyclopedia

but its definitely a cool thing they know how to do!! and the tech is only advancing as time goes on : ) so excited what science will bring over the next 5-10 years! : D

 

[juced_porkchop]

That is correct.
Who knows if the ugl is even buying from a legit source themselves.

100% right! and why i avoid HGH mostly... too much crap out there...

 

[49ER]

UGL's do not manufacturer rHGH... every single one of them buys it from the source in China with whatever color top or label they want

These manufacturers in China make the so-called pharm grade and every other grade

I wasn't aware they made all hgh what do you mean so called pharm grade? So are seros saizen for example pharm grade? And so why are so called pharm so much better than generics? This is a legit question by the way cuz I've used both and im in love with seros

 

[China_Wall]

I wasn't aware they made all hgh what do you mean so called pharm grade? So are seros saizen for example pharm grade? And so why are so called pharm so much better than generics? This is a legit question by the way cuz I've used both and im in love with seros

A "pharm grade" and a "clean" generic are the same products, the only difference is the quality control around the "pharm grade" product through the packaging process.

The problem most of us run into is we acquire our GH from sources that are looking to nickel and dime whenever possible... for example they order GH in 5iu vials and label it as 10iu, or even trickier they have 1 or 2iu of GH and the rest of the vial filled with igf-1, or the really shady ones use HCG

In the end it all comes down to the source, but the best way... and not always possible... is to acquire product direct from the manufacturer

 

[anzel]

China , maybe you can also chime in on another detail. .... Is it possible to produce something that can give you high numbers on a GH serum blood test (3 hrs after pinning 10iu) and also give you sides such as CTS but NOT be real HGH?

 

[anzel]

IGF-1 requires the same recombinant technology as is used to make HGH, so essentially all IGF-1 generated by peptide companies is inactive (R3 or otherwise).

It is all made in modified bacteria (E.coli) that have been modified with human enzymes to generate the correct linkage between the 2 chains, which ensures it is folded correctly and active (HGH and IGF-1 included, even insulin)

Yeah and there is only one peptide company that claims they use E.coli for their igf and thats RUI. If you find the research companies that won't sell to the general public , the prices for their IGF is very high bevcause its so expansive to make. These are the original companies that BB's were buying from before they realized what was going on. Now if you want to buy from them you have to prove your a lab or university ie a legit scientist. And they wont mail it to your house.

 

[49ER]

A "pharm grade" and a "clean" generic are the same products, the only difference is the quality control around the "pharm grade" product through the packaging process.

The problem most of us run into is we acquire our GH from sources that are looking to nickel and dime whenever possible... for example they order GH in 5iu vials and label it as 10iu, or even trickier they have 1 or 2iu of GH and the rest of the vial filled with igf-1, or the really shady ones use HCG

In the end it all comes down to the source, but the best way... and not always possible... is to acquire product direct from the manufacturer

Last question cuz this has haunted me and ive completely steered away from generics since.... my generics scored 36.2 i tested 3 orders total always were in the 30's is it safe to say they were dosed right? This is what makes me think there is something really bad about them i didnt gain shit looked like shit no better sleep just held water had horrible cts had scars from injecting it was a shitty 5 months. Now in seros less ius just amazing sleep noticeably leaner i used to eat cleaner back then too. I just dont get this shit so maybe you can chime in cuz to me theres a huge difference

 

[China_Wall]

China , maybe you can also chime in on another detail. .... Is it possible to produce something that can give you high numbers on a GH serum blood test (3 hrs after pinning 10iu) and also give you sides such as CTS but NOT be real HGH?

I would say in "most" cases if the sides are real, the product is real... but there will always be some exceptions

 

[China_Wall]

Last question cuz this has haunted me and ive completely steered away from generics since.... my generics scored 36.2 i tested 3 orders total always were in the 30's is it safe to say they were dosed right? This is what makes me think there is something really bad about them i didnt gain shit looked like shit no better sleep just held water had horrible cts had scars from injecting it was a shitty 5 months. Now in seros less ius just amazing sleep noticeably leaner i used to eat cleaner back then too. I just dont get this shit so maybe you can chime in cuz to me theres a huge difference

Hey bro... this is a good inquiry that leaves me stumped. I've had nothing, but good experience running generics in the past

 

[Moppy1]

Last question cuz this has haunted me and ive completely steered away from generics since.... my generics scored 36.2 i tested 3 orders total always were in the 30's is it safe to say they were dosed right? This is what makes me think there is something really bad about them i didnt gain shit looked like shit no better sleep just held water had horrible cts had scars from injecting it was a shitty 5 months. Now in seros less ius just amazing sleep noticeably leaner i used to eat cleaner back then too. I just dont get this shit so maybe you can chime in cuz to me theres a huge difference

China does make legit HGH, so even though it might be generic, my guess is that if it registers on the plasma test in the 30s, it is gtg.

 

[anzel]

Im getting plasma scores in the 30s as well and like what 49er said , after 9 months I can't say I am greatly impressed. I do feel I am leaner but I am also a pretty good eater. I am at the end of what I decided would be my last kit and decided to just blow it out at 8iu a day pinned 1st thing.
49er you kinda convinced me to steer clear of generics but Moppy and China are making me think twice!

 

[China_Wall]

China does make legit HGH, so even though it might be generic, my guess is that if it registers on the plasma test in the 30s, it is gtg.

^^ I agree with this

Not only does China make legit GH, but I don't know of any other countries manufacturing GH. Most if not all of the top pharm companies source their GH from China.

The biggest mistake made by people running GH is simply not running enough, and for not long enough. I would say if u can't run minimum 5iu per day, 10iu even better, and for minimum 1 year, don't do it

 

[jupiterlocal]

^^ I agree with this

Not only does China make legit GH, but I don't know of any other countries manufacturing GH. Most if not all of the top pharm companies source their GH from China.

The biggest mistake made by people running GH is simply not running enough, and for not long enough. I would say if u can't run minimum 5iu per day, 10iu even better, and for minimum 1 year, don't do it

5iu or 10? Most sources say 2iu per day? I only ask because I am looking to begin when i come off current cycle. I also ask, because I equate price of the hgh to how long it would last me so i can budget correctly. Also trying to avoid having the big pregnant stomach and big organs you see from people who abuse hgh.