Fullgoldcrown
New member
In the past 48 hours I have searched the internet like a madman and have found countless viewpoints and write ups on igf-1 long r3. THE ONLY THING I WANT TO KNOW IS... Does this peptide cause hyperplasia!? I will provide what I have found but I'd love to hear people's opinions of this wonderful peptide.
None of the following is my work and I am simply posting what I've found elsewhere.
My favorite work is from Juced and his write ups on this website!
THIS IS FROM RUSSIAN STAR
IGF1-LR3 What is it?
IGF-1 is basically a polypeptide hormone that has the same some of the same molecular properties as insulin. IGF dose actually stand for insulin-like growth factor. IGF-1 is mainly responsible for long bone growth in children and it also affects muscle growth and repair of adults. Long R3 IGF-1 is a more potent version of IGF-1. It's chemically altered i like to think "enhanced" to prevent deactivation by IGF-1 binding proteins in the bloodstream. This results in a longer half-life of 20-30 hours instead of 20 min... So that means a far more effective version than the short chain we we re perhaps more familiar with.
IGF1-LR3 What does it do?
IGF-1LR3 greatly boosts muscle mass by inducing a state of muscle hyperplasia (increase in number of new muscle cells) in the MUSCLE WHERE ITS INJECTED!!
So think of it as muscle cell proliferation, or even the splitting of the cell so 1 becomes 2... Thats why its perfect on cycle when you get increased muscle cell growth too.
But why is IGF better than HGH? The reason being is HGH causes IGF levels to rise in the liver first, then then the muscle, Whereas IGF-LR3 causes localised IGF levels to rocket.
What other benefits?
Taken froma study in germany..
"Tissue build up is one of the main features of IGF-1, so I'd say it's of greater value. IGF-1 can genetically change muscular and cellular counts within the body; it can also enhance the body's ability to regenerate damaged tissue. In fact, IGF-1 is now under intensive research for its potential to repair tissue in burn patients, and for its regenerative effects on AIDS patients suffering from muscular wasting. Immediate effects are, of course, impossible to observe since it takes a respectable amount of time to see any visible changes in muscular repair"
But muscle size and shape can be seen quite quickly through a course of IGF-LR3
Doseage and use..
The best dose for muscle cell proliferation is 40mcg bi-lateraly for men, and 20mcg for women... so 40mcg in one bicep and 40mcg in the other Pre-workout.
And 20 in each bicep for women. This can be done in any 2 matching muscle groups.
This should be done for 40 days max and then have 30 days off.
What you need to be carefull of is adequate carb intake when using IGF, Especialy this version as its long lasting, it will literaly leech glucose to cause its localised muscle enhancing effects, similar to the way in wich insulin works, This goes on for 7-10 hours, You should take in 20g of carbs 5 grams slow release and 15 g fast, for every hour its active for the first 7 hours.. so it looks like this.
Based on a mans dose, so a women halfs this.
Pre-workout.. 40mcg bi-lateraly. Then pwo meal of 40g carbs, 30 slow release and 10g fast release carbs... that covers you for 2 hours.
Post-workout. 40 grams carbs 30 grams low gi or slow release, and 10g fast release carbs. That covers you for 2 more hours..
2 Hours later so 4 hours since the injection the same again... that takes you up to 6 hours, at this point just consume carbs when you feel the need... if you feel light headed, or any signs of hypoglycemia.
Some people prefer to dose 70 g carbs with there pre-workout meal, and 70 grams of carbs 4 hours later, but themost anabolic option is the one i outlined, causing a constant supply of everything you need to maximise its effects.
Only dose on workout days and a maximum of 3 times a week.
Use a 1" insulin syringe and only inject directly into muscle, and reconstitue with Acetic acid, once reconstituted keep refrigerated and use within 6 months.
Why dose pre-workout?
When do you get muscle cell proliferation? This is when the muscle actualy breaks down during intense exercise, this causes localised IGF-1 levels to sky rocket, Thats why Arachadionic acid works, because it increased localised IGF-1 levels, causing an increased inflammatry response to muscle degradation or breakdown, So by using IGF-LR3 pre workout you recieve the benefits of Hyperplasia straight away, without waiting for nearly 2 hours to use your IGF.. So you increase the window of growth time period, during its most significant period.. You have just provided your muscle everything it needs for muscle growth at EXACTLY the right time.. before its broken down. Plus by eating your Pre workout meal you fuel your workout and allow for your muscles to take advantage of the huge pumps IGF-LR3 can cause as your muscles are flooded with nutrients, blood and increased localised IGF-1 levels.
Russians experiences.
Using the protocol i outlined above, after weeks of experimenting and trying new ideas i found great success.
I focused on my triceps and biceps, In 4 weeks of the above protocol i added a depth to my tricep horseshoe and shape that i havent seen in many other bodybuilders, and i increased the severity of my bicep peak, 0.5" increase in arm size, now that may not seem much, but when you think on most anabolic cycles that last 5 weeks or more those kind of gains are not really that common, i saw that as a big result especialy as i ran it stand alone, With no additional anabolics.
The next time i run it, i will incorporate Need2slin to increase liver igf-1 levels and increased insulin response so increasing the effectiveness of the igf-lr3.
Possible sides.
Lethargy is a big one as carbs are used to increase muscle cell proliferation and not used as readily for fuel.
The big one to watch out for is burning from the acetic acid when its reconstituted, and the Hypoglycemia, Always have plenty of carbs on hand in case the sides hit you hard!!!
–-----------------------------------------------
By Todd Lee M.D.
Warning: This article is the real deal, there is no sugar coating it, this is my professional opinion on this incredible grey market growth agent. If you think drug use is bad then make sure you carve hypocrite on your forehead the next time you have a cigarette, beer, or margarita. Personally I think there is more honor in using drugs which make your body stronger and harder to kill than drugs that make your body sick, weak, and are only used as a crutch, vice, or to block out your regrets.
IGF-1 LR3 is quite possibly the most important peptide you can use while building mass. In addition to being capable of growing all muscles in your body and burning fat if you inject it subcutaneously, it has the unique ability to grow a specific muscle if you inject it in a weak body part and only that part. In other words if you have poor lats, you can inject your lats and they may catch up to other body parts.
Insulin-Like Growth Factor
Or IGF for short, is a very complicated hormone. Everyone is familiar with Growth Hormone (GH) and its effects to one degree or another but some may be unaware that it isn’t GH that grows muscle, its a metabolite of GH: IGF, that grows muscle. IGF is the primary muscle builder and bone lengthener during puberty. It in one way or another sets your genetic maximum height and muscle. It amplifies the effects of testosterone and that,along with the fact that IGF-1 binding protein 3 concentration decreases in men after puberty is why men grow more muscle in puberty than women.
IGF-1 LR3 Does a Ton of Cool Stuff!
IGF-1 LR3 is the absolute best additive to a cycle. It increases amino acid transport to cells, increases glucose transport, increases protein synthesis, decreases protein degradation, and increases RNA synthesis. If injected subcutaneously it liberates fat from adipose tissues so you use your own body fat to grow muscle, allowing for recomposition! In addition it makes the muscle cell more sensitive to insulin amplifying the effects of natural insulin from carbohydrate consumption or allowing you to use less insulin if you’re injecting it post workout to drive your post workout carbs into your muscle faster. It has also been shown to regrow lost hair and increase testicle size.
THE ABSOLUTE MOST IMPORTANT FACTOR IN WHY IGF-1 ROCKS is because it directly causes satellite cell migration, nuclei donation, and subsequently Hyperplasia!
IGF-1 LR3
The parent Hormone, IGF, has many subtypes. the best for muscle growth is type one. This only has a 10-20 minute half life in the blood stream so a chemical modification is made: amino acid at position 3 is replaced with arginine hence R3. An additional 13 amino acid long tail is added to make it longer, that’s where the L comes from. These 2 modifications make the half like closer to 12 hours. Huge difference which has been proven by mountains of research to make IGF-1 LR3 more effective than IGF-1.
None of the following is my work and I am simply posting what I've found elsewhere.
My favorite work is from Juced and his write ups on this website!
THIS IS FROM RUSSIAN STAR
IGF1-LR3 What is it?
IGF-1 is basically a polypeptide hormone that has the same some of the same molecular properties as insulin. IGF dose actually stand for insulin-like growth factor. IGF-1 is mainly responsible for long bone growth in children and it also affects muscle growth and repair of adults. Long R3 IGF-1 is a more potent version of IGF-1. It's chemically altered i like to think "enhanced" to prevent deactivation by IGF-1 binding proteins in the bloodstream. This results in a longer half-life of 20-30 hours instead of 20 min... So that means a far more effective version than the short chain we we re perhaps more familiar with.
IGF1-LR3 What does it do?
IGF-1LR3 greatly boosts muscle mass by inducing a state of muscle hyperplasia (increase in number of new muscle cells) in the MUSCLE WHERE ITS INJECTED!!
So think of it as muscle cell proliferation, or even the splitting of the cell so 1 becomes 2... Thats why its perfect on cycle when you get increased muscle cell growth too.
But why is IGF better than HGH? The reason being is HGH causes IGF levels to rise in the liver first, then then the muscle, Whereas IGF-LR3 causes localised IGF levels to rocket.
What other benefits?
Taken froma study in germany..
"Tissue build up is one of the main features of IGF-1, so I'd say it's of greater value. IGF-1 can genetically change muscular and cellular counts within the body; it can also enhance the body's ability to regenerate damaged tissue. In fact, IGF-1 is now under intensive research for its potential to repair tissue in burn patients, and for its regenerative effects on AIDS patients suffering from muscular wasting. Immediate effects are, of course, impossible to observe since it takes a respectable amount of time to see any visible changes in muscular repair"
But muscle size and shape can be seen quite quickly through a course of IGF-LR3
Doseage and use..
The best dose for muscle cell proliferation is 40mcg bi-lateraly for men, and 20mcg for women... so 40mcg in one bicep and 40mcg in the other Pre-workout.
And 20 in each bicep for women. This can be done in any 2 matching muscle groups.
This should be done for 40 days max and then have 30 days off.
What you need to be carefull of is adequate carb intake when using IGF, Especialy this version as its long lasting, it will literaly leech glucose to cause its localised muscle enhancing effects, similar to the way in wich insulin works, This goes on for 7-10 hours, You should take in 20g of carbs 5 grams slow release and 15 g fast, for every hour its active for the first 7 hours.. so it looks like this.
Based on a mans dose, so a women halfs this.
Pre-workout.. 40mcg bi-lateraly. Then pwo meal of 40g carbs, 30 slow release and 10g fast release carbs... that covers you for 2 hours.
Post-workout. 40 grams carbs 30 grams low gi or slow release, and 10g fast release carbs. That covers you for 2 more hours..
2 Hours later so 4 hours since the injection the same again... that takes you up to 6 hours, at this point just consume carbs when you feel the need... if you feel light headed, or any signs of hypoglycemia.
Some people prefer to dose 70 g carbs with there pre-workout meal, and 70 grams of carbs 4 hours later, but themost anabolic option is the one i outlined, causing a constant supply of everything you need to maximise its effects.
Only dose on workout days and a maximum of 3 times a week.
Use a 1" insulin syringe and only inject directly into muscle, and reconstitue with Acetic acid, once reconstituted keep refrigerated and use within 6 months.
Why dose pre-workout?
When do you get muscle cell proliferation? This is when the muscle actualy breaks down during intense exercise, this causes localised IGF-1 levels to sky rocket, Thats why Arachadionic acid works, because it increased localised IGF-1 levels, causing an increased inflammatry response to muscle degradation or breakdown, So by using IGF-LR3 pre workout you recieve the benefits of Hyperplasia straight away, without waiting for nearly 2 hours to use your IGF.. So you increase the window of growth time period, during its most significant period.. You have just provided your muscle everything it needs for muscle growth at EXACTLY the right time.. before its broken down. Plus by eating your Pre workout meal you fuel your workout and allow for your muscles to take advantage of the huge pumps IGF-LR3 can cause as your muscles are flooded with nutrients, blood and increased localised IGF-1 levels.
Russians experiences.
Using the protocol i outlined above, after weeks of experimenting and trying new ideas i found great success.
I focused on my triceps and biceps, In 4 weeks of the above protocol i added a depth to my tricep horseshoe and shape that i havent seen in many other bodybuilders, and i increased the severity of my bicep peak, 0.5" increase in arm size, now that may not seem much, but when you think on most anabolic cycles that last 5 weeks or more those kind of gains are not really that common, i saw that as a big result especialy as i ran it stand alone, With no additional anabolics.
The next time i run it, i will incorporate Need2slin to increase liver igf-1 levels and increased insulin response so increasing the effectiveness of the igf-lr3.
Possible sides.
Lethargy is a big one as carbs are used to increase muscle cell proliferation and not used as readily for fuel.
The big one to watch out for is burning from the acetic acid when its reconstituted, and the Hypoglycemia, Always have plenty of carbs on hand in case the sides hit you hard!!!
–-----------------------------------------------
By Todd Lee M.D.
Warning: This article is the real deal, there is no sugar coating it, this is my professional opinion on this incredible grey market growth agent. If you think drug use is bad then make sure you carve hypocrite on your forehead the next time you have a cigarette, beer, or margarita. Personally I think there is more honor in using drugs which make your body stronger and harder to kill than drugs that make your body sick, weak, and are only used as a crutch, vice, or to block out your regrets.
IGF-1 LR3 is quite possibly the most important peptide you can use while building mass. In addition to being capable of growing all muscles in your body and burning fat if you inject it subcutaneously, it has the unique ability to grow a specific muscle if you inject it in a weak body part and only that part. In other words if you have poor lats, you can inject your lats and they may catch up to other body parts.
Insulin-Like Growth Factor
Or IGF for short, is a very complicated hormone. Everyone is familiar with Growth Hormone (GH) and its effects to one degree or another but some may be unaware that it isn’t GH that grows muscle, its a metabolite of GH: IGF, that grows muscle. IGF is the primary muscle builder and bone lengthener during puberty. It in one way or another sets your genetic maximum height and muscle. It amplifies the effects of testosterone and that,along with the fact that IGF-1 binding protein 3 concentration decreases in men after puberty is why men grow more muscle in puberty than women.
IGF-1 LR3 Does a Ton of Cool Stuff!
IGF-1 LR3 is the absolute best additive to a cycle. It increases amino acid transport to cells, increases glucose transport, increases protein synthesis, decreases protein degradation, and increases RNA synthesis. If injected subcutaneously it liberates fat from adipose tissues so you use your own body fat to grow muscle, allowing for recomposition! In addition it makes the muscle cell more sensitive to insulin amplifying the effects of natural insulin from carbohydrate consumption or allowing you to use less insulin if you’re injecting it post workout to drive your post workout carbs into your muscle faster. It has also been shown to regrow lost hair and increase testicle size.
THE ABSOLUTE MOST IMPORTANT FACTOR IN WHY IGF-1 ROCKS is because it directly causes satellite cell migration, nuclei donation, and subsequently Hyperplasia!
IGF-1 LR3
The parent Hormone, IGF, has many subtypes. the best for muscle growth is type one. This only has a 10-20 minute half life in the blood stream so a chemical modification is made: amino acid at position 3 is replaced with arginine hence R3. An additional 13 amino acid long tail is added to make it longer, that’s where the L comes from. These 2 modifications make the half like closer to 12 hours. Huge difference which has been proven by mountains of research to make IGF-1 LR3 more effective than IGF-1.
