Need to try Anastrazole again...help

willnorthwest

willnorthwest

New member
Hey guys, I got a question about Anastrazole. I have been doing 50mg cyp every 4 days for awhile now, and about a month ago i decided(with permission from my doc) to experiment with my dosage a bit. I started doing 70mgs every 4 days. For the most part, everything has gone really good. Strength, endurance, and libido are improved.

The major problem, however, is that my Estradiol is now elevated at 60 (standard e2 test, not e2 sensitive with upper reference range at 41), and I have started to break out with really bad cystic acne on my back and some light acne on my chest. My doctor recommended either lowering my dose back to 50 every 4 days or start an Aromatase inhibitor (AI). I really do not want to lower my cyp dosage due to the perceived benefits, so I guess I will try the Aromatase inhibitor (AI). I have tried anastrazole before, however the last time I did, I pretty much crashed my estradiol levels. I was taking .5mg every 3 days then when that happened. My question is, SHOULD I TRY .25MG EVERY 4 DAYS? And if so, when would be the best day to take it (i have heard the day before your cyp shot is best). Im only looking to reduce, but not crash my e2. All suggestions and recomendations are welcome....thanks in advance
 
I think .25mg would be a better place to start. I think taking the Aromatase inhibitor (AI) the day after T shot is best - ideally you want both medications to peak at the same time and T has a longer onset and half-life.
 
I would take .25mg of adex with each injection. Easier to remember to take it then. If you want to take it the day after that is fine too.

Why not inject every 3.5 days? Just adjust your dose so you take the same amount in a week. Then you would always be injecting on the same days of the week. For example, Sat mornings and Tue evenings. Once again, seems easier to remember this way.
 
I found that acne tends to hit when the test level is diminishing and the estrogen level is increasing.....for example if you are doing weekly shots.....on day 5-6 one would start to break out due to the imbalance. Then on day 7, you do your injection and by days 9-10, the acne subsides. In your situation, I would do my shot on Day 1 (of course) then on day 3 try .25mg of anastrozole. Try that for 2 weeks. If you still break out then try .5mg of anastrozole on day 3. You could also try .25mg on day 2 and .25 on day 3. You have to see what works best for you. I would imagine the .25mg on day 3 will pretty much correct the problem. Let us know what you decide and how it works for your.
 
Thanks guys....so would you guys agree that the cause of my cystic acne is due to the elevated Estrogen levels and that a low dose Aromatase inhibitor (AI) should correct the problem? I am willing to try the Aromatase inhibitor (AI) thing again, but only if it will help with the acne. Im not having any other high e2 symptoms, which is odd. I havent changed anything else in my protocol...Im still taking 25mg DHEA and 30mg Pregnenalone every day. Should i drop them, or just start the low dose Aromatase inhibitor (AI) and see how things shake out?
 
willnorthwest said:
Thanks guys....so would you guys agree that the cause of my cystic acne is due to the elevated Estrogen levels and that a low dose Aromatase inhibitor (AI) should correct the problem? I am willing to try the Aromatase inhibitor (AI) thing again, but only if it will help with the acne. Im not having any other high e2 symptoms, which is odd. I havent changed anything else in my protocol...Im still taking 25mg DHEA and 30mg Pregnenalone every day. Should i drop them, or just start the low dose Aromatase inhibitor (AI) and see how things shake out?
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Your E2 is high. You need to control it.

High E2 definitely causes acne in men.
 
Okay...so I went back to the docs office the day after I tested at 60 on e2 test to make sure that the reading was correct. They redrew blood and yesterday I found out that e2 has risen to 70! T level was solid at 800 24hours after inject. Needless to say, I started my Aromatase inhibitor (AI) protocol. I took .25mg of liquidex friday (10/5/13)afternoon. At this point, im still struggling with deciding on how often I should dose it. Do you guys think it would be safe for me to dose .25mg eod? That would be around .875/week. My concerns are that .25 e3d wont be enough to lower my e2 effectively, however im also a little scared of taking too much. Last issue is that im using liquidex from board sponsor. Can anyone here state with confidence that liquidex is as effective as pharma grade arimidex? All comments and suggestions are welcome.
 
willnorthwest said:
Okay...so I went back to the docs office the day after I tested at 60 on e2 test to make sure that the reading was correct. They redrew blood and yesterday I found out that e2 has risen to 70! T level was solid at 800 24hours after inject. Needless to say, I started my Aromatase inhibitor (AI) protocol. I took .25mg of liquidex friday (10/5/13)afternoon. At this point, im still struggling with deciding on how often I should dose it. Do you guys think it would be safe for me to dose .25mg eod? That would be around .875/week. My concerns are that .25 e3d wont be enough to lower my e2 effectively, however im also a little scared of taking too much. Last issue is that im using liquidex from board sponsor. Can anyone here state with confidence that liquidex is as effective as pharma grade arimidex? All comments and suggestions are welcome.
Click to expand...

Start with the lower dose as previously recommended. Stay on it for 3-4 weeks and get labs again. Crashing your E is not fun. It is a lot easier to lower your E than get it back up after you crashed it.

Why didn't your doc write you a script for an AI?
 
willnorthwest said:
Okay...so I went back to the docs office the day after I tested at 60 on e2 test to make sure that the reading was correct. They redrew blood and yesterday I found out that e2 has risen to 70! T level was solid at 800 24hours after inject. Needless to say, I started my Aromatase inhibitor (AI) protocol. I took .25mg of liquidex friday (10/5/13)afternoon. At this point, im still struggling with deciding on how often I should dose it. Do you guys think it would be safe for me to dose .25mg eod? That would be around .875/week. My concerns are that .25 e3d wont be enough to lower my e2 effectively, however im also a little scared of taking too much. Last issue is that im using liquidex from board sponsor. Can anyone here state with confidence that liquidex is as effective as pharma grade arimidex? All comments and suggestions are welcome.
Click to expand...

1. How long did you try out .25mg E3D? I can't tell if you were just thinking about it, or if you actually moved to that protocol. I do think that should be enough given the very small dose of testosterone you're on.

2. This is a tricky question to answer as this section deals specifically with the use of prescribed drugs, not research chemicals. I can however say in a general sense that research chemicals from a red-lion that frequents this board do happen to be quite effective in studies involving their use. ;) If your doctor asked you whether you want to reduce your dose or go on an Aromatase inhibitor (AI), why aren't you using a prescribed Aromatase inhibitor (AI) though?

3. From here on out (assuming you didn't try .25mg E3D): I would start at .25mg E3D and see how that goes. You will likely know if you're crashing your E2 within a few days as adex has a very quick method of action (48hrs), and can make appropriate adjustments on the fly. I do want you to verify with blood work though as going by how you feel isn't the best when fine-tuning estradiol. Low E2 and high E2 share so many sides, it's really hard to discern which is which some times.

If you still have elevated E2 with .25mg E3D, I'd move to .25mg EOD as that's slightly less than just doubling your Aromatase inhibitor (AI) and possibly landing you back where you were. Hopefully this will be enough, and keep that nasty estrogen at bay. :)

My .02c :spin:


Sorry for the delay will, I totally got side tracked before I had a chance to reply. :worried:
 
He did, but all we could get is the 1mg pills. I tried cutting them last night, but I can tell that they are not sliced completely even...ie one side is bigger than the other. Maybe it doesnt matter though, as long as I take the whole 1mg pill over the alloted time frame. Do you think I should do that or stick with the liquidex? The reason im considering eod instead of e3d now is because not only is my e2 high, but it is rising! When I first posted this thread, I had a e2 test result of 60, and then a day later it was retested at 70, so im thinking maybe I should be just a little more aggressive with the Aromatase inhibitor (AI). Not contemplating going to .5mg, but still considering trying .25 eod instead of .25 e3d.
 
willnorthwest said:
He did, but all we could get is the 1mg pills. I tried cutting them last night, but I can tell that they are not sliced completely even...ie one side is bigger than the other. Maybe it doesnt matter though, as long as I take the whole 1mg pill over the alloted time frame. Do you think I should do that or stick with the liquidex? The reason im considering eod instead of e3d now is because not only is my e2 high, but it is rising! When I first posted this thread, I had a e2 test result of 60, and then a day later it was retested at 70, so im thinking maybe I should be just a little more aggressive with the Aromatase inhibitor (AI). Not contemplating going to .5mg, but still considering trying .25 eod instead of .25 e3d.
Click to expand...

You can get a pill splitter for relatively cheap at just about any pharmacy which should make that task a TON easier. Were you taking .25mg E3D or...? I ask as anastrozole is VERY powerful and as you've seen can crush that E2 very quickly. I always take baby steps with the stuff (same with letrozole) as it's much easier to bring estrogen down than letting it come back up. A 10pg/mL difference isn't really THAT much to worry about as the time of the day could easily cause that to change.

If you were dosing at .25mg E3D, then EOD would be the next step in my humble opinion. :)
 
willnorthwest said:
He did, but all we could get is the 1mg pills. I tried cutting them last night, but I can tell that they are not sliced completely even...ie one side is bigger than the other. Maybe it doesnt matter though, as long as I take the whole 1mg pill over the alloted time frame. Do you think I should do that or stick with the liquidex? The reason im considering eod instead of e3d now is because not only is my e2 high, but it is rising! When I first posted this thread, I had a e2 test result of 60, and then a day later it was retested at 70, so im thinking maybe I should be just a little more aggressive with the Aromatase inhibitor (AI). Not contemplating going to .5mg, but still considering trying .25 eod instead of .25 e3d.
Click to expand...

You can cut the 1mg pills into quarters. They won't be perfectly even in size but close enough.

You are overreacting to the E2 labs. Don't freak out. You aren't in the freak-out high range yet. I have been well into the triple digits before! Start low and increase the dose if labs indicate you need to.
 
Megatron28 said:
You can cut the 1mg pills into quarters. They won't be perfectly even in size but close enough.

You are overreacting to the E2 labs. Don't freak out. You aren't in the freak-out high range yet. I have been well into the triple digits before! Start low and increase the dose if labs indicate you need to.
Click to expand...



What he said.... :)
 
I take 100mg test cyp on Monday morning and Thursday morning and .5mg Anastrazol on Mon and Thurs nights before bed. This was recommended by doc. I take 250mg Human Chorionic Gonadotropin (HCG) Wednesday and Saturday mornings. A bit of an odd split but I feel good. Still waiting on my labs.
 
alright guys....got my bloodwork done after initiating adex for 3 weeks. on trough day, and before my scheduled cyp shot, e2 came back at less than 20, and total testosterone came in at 530. I started adex 3 weeks ago when my e2 was 70. i have been taking .25mg adex e3d along with 350iu Human Chorionic Gonadotropin (HCG) e4d, and 70mg cyp e4d. I must be a huge adex over-responder, because yet again, ive probably tanked my e2 on a very small dose. at this point, i should probably back off the adex altogether, but i would definitely like some feedback on the issue. also, a 530 total t trough score is not very high either, and I would like some feedback as to whether i should talk to my doctor about upping my cyp dose a bit.

e2 test was standard and not sensitive btw.
 
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