problems to calculate theoretical yield...(peptide synthesis)

[Valine_Leucine]

Hey guys,

I have troubles to calculate the yield of a peptide synthesis. The point is that I dont understand how I have to use the substitution of the aminoacid in the resin. I will put you one example:

Peptide that I want to synthesize: Lys-Ser-Ala-Wang Resin
Fmoc-Ala-Wang Resin (substitution 0.72 mmol/g)

the goal is to synthesize 0.1 mmol peptide so it means that I have to use 0.139 g of the a.a.-resin (m=0.1mmol peptide/0.72 mmol/g = 0.139g).

So how I have to calculate the theoretical yield?

Thanks for advance

 

[UserAt204]

Sure

 

[Valine_Leucine]

Sure...what?

 

[tkaltenbach]

Wheres Humdiddly at ????? I think he could handle this one. lol