Solu-cortef

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<h1>SOLU-CORTEF</h1><P> SOLU-CORTEF Sterile Powder is an anti-inflammatory glucocorticoid, which contains
hydrocortisone sodium succinate as the active ingredient. SOLU-CORTEF Sterile
Powder is available in several packages for intravenous or intramuscular administration.
100 mg Plain—Vials containing hydrocortisone sodium succinate equivalent to 100 mg
hydrocortisone, also 0.8 mg monobasic sodium phosphate anhydrous, 8.73 mg dibasic
sodium phosphate dried. SOLU-CORTEF 100 mg plain does not contain diluent (see
DOSAGE and ADMINISTRATION, Preparation of Solutions).
ACT-O-VIAL® System (Single-Dose Vial) in four strengths:
100 mg
ACT-O-VIAL
250 mg
ACT-O-VIAL
500 mg
ACT-O-VIAL
1000 mg
ACT-O-VIAL
Each 2 mL
contains:
(when mixed)
Each 2 mL
contains:
(when mixed)
Each 4 mL
contains:
(when mixed)
Each 8 mL
contains:
(when mixed)
Hydrocortisone
sodium succinate
equiv. to
100 mg
Hydrocortisone
equiv. to
250 mg
Hydrocortisone
equiv. to
500 mg
Hydrocortisone
equiv. to
1000 mg
Hydrocortisone
Monobasic sodium
phosphate anhydrous
0.8 mg 2 mg 4 mg 8 mg
Dibasic sodium
phosphate dried
8.73 mg 21.8 mg 44 mg 87.32 mg
Benzyl alcohol
added as preservative
18.1 mg 16.4 mg 33.4 mg 66.9 mg
When necessary, the pH of each formula was adjusted with sodium hydroxide so that the
pH of the reconstituted solution is within the USP specified range of 7 to 8.
The chemical name for hydrocortisone sodium succinate is pregn-4-ene-3,20-dione,21-
(3-carboxy-1-oxopropoxy)-11,17-dihydroxy-, monosodium salt, (11β)- and its molecular
weight is 484.52.</p>
 
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