Anecdotal Evidence

THIS IS WHAT PROBABLY HAPPENED TO YOU:
by Dr. Marriano, MD
So what happens when testosterone is replaced?

There is a reversal of some of the initial signaling problems.

Because there is a larger number of dopamine receptors from the dopamine signaling deficit caused by the loss of testosterone, there is dopamine supersensitivity to the surge of dopamine signaling that accompanies the increase in testosterone with replacement. This can cause a high - with heightened sex drive, alertness. and an elevated mood.

Testosterone would also free up thyroid hormone by reducing thyroid binding globulin, reversing estrogen's effects, improving function from this angle. This would improve energy

Testosterone would then reduce excessive norepinephrine signaling, which as it comes more in normal physiologic strength, helps dopamine in providing a higher level of libido, sex drive, and an emotional high.

The testosterone to estrogen ratio would improve, reducing effects of excess estrogen. Insulin signaling is reduced. The body becomes less in an inflammatory state.

The person feels better, if not feels a high from the initial treatment with testosterone.

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Over time, however, with increased dopamine signaling, dopamine receptor production is reduced back to a normal amount. Dopamine, as the reward signal, the feel good signal, can't be elevated for a prolonged period of time excessively, without problems occurring. It no longer becomes a reward signal if it is elevated for a prolonged period of time. Tolerance, through receptor reduction, occurs.

After the initial high, other problems also occur.

Exogenous testosterone suppresses testicular thyroid releasing hormone production. This reduces thyroid hormone production, undoing the initial increase in free thyroid hormone that testosterone caused. If there is hypothyroidism in the first place, this exacerbates that problem.

If there are other neurotransmitter, hormone, cytokine signaling problems or metabolic-nutritional problems outside of hypogonadism, these may complicate or undo what testosterone initially did.

If the man aromatizes testosterone to estrogen excessively, problems with excessive estrogen occur. If aromatization is not enough, then problems with too little estrogen occur. In either case, sex drive is impaired.

Thus, the hypogonadal man returns to Earth. And the initial high is lost.
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Romeo B. Mariano, MD, physician, psychiatrist
 
I would recommend going to PrivateMD Labs as has already been suggested, and add the SHBG test. Guys with SHBG on the low side seem to be screwed when it comes to testosterone replacement therapy (TRT). Most people think that "High SHBG = Bad" and "Low SHBG = Good" but it is more like your E2 - both too high and too low are bad, and if its genetically low like me, testosterone replacement therapy (TRT) is probably not going to work well (or at all). If one does a Google search on guys with low SHBG on testosterone replacement therapy (TRT), the results are not promising, even though all the guys with normal SHBG will keep insisting that it works (becuase it works so well for them with their more normal SHBG level)
 
I would recommend going to PrivateMD Labs as has already been suggested, and add the SHBG test. Guys with SHBG on the low side seem to be screwed when it comes to testosterone replacement therapy (TRT). Most people think that "High SHBG = Bad" and "Low SHBG = Good" but it is more like your E2 - both too high and too low are bad, and if its genetically low like me, testosterone replacement therapy (TRT) is probably not going to work well (or at all). If one does a Google search on guys with low SHBG on testosterone replacement therapy (TRT), the results are not promising, even though all the guys with normal SHBG will keep insisting that it works (becuase it works so well for them with their more normal SHBG level)

New, it's probably best that we move your experience to one thread and stop polluting every thread that 'TRT doesn't work for some people'. We need to take a look at your blood work, before/during/after to see exactly what is happening to you specifically. Truth be told, testosterone replacement therapy (TRT) does work for EVERYONE. You're injecting a hormone directly into your muscles, you will increase your testosterone levels - without a doubt. The reality of your situation may be that testosterone levels may not be the center of your problems. Maybe it's depression, maybe it's thyroid, maybe it's sleep - who knows at this point (without analyzing your blood work). What is not accurate is that testosterone replacement therapy (TRT) 'doesn't work for some'. It works for everyone - it's just whether or not Test was the underlying problem that determines if testosterone replacement therapy (TRT) will alleviate your symptoms.

Again, lets keep all of your issues to one thread and discuss them there. Posting your negative experience in every thread will only serve to diminish the hope of some that testosterone replacement therapy (TRT) will be the answer to their problems.
 
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