<H1>Argatroban</H1><P>Argatroban is a synthetic direct thrombin inhibitor derived from L-arginine. The chemical
name for Argatroban is 1-[5-[(aminoiminomethyl)amino]-1-oxo-2-[[(1,2,3,4-tetrahydro-3-
methyl-8-quinolinyl)sulfonyl]amino]pentyl]-4-methyl-2-piperidinecarboxylic acid, monohydrate.
Argatroban has 4 asymmetric carbons. One of the asymmetric carbons has an R configuration
(stereoisomer Type I) and an S configuration (stereoisomer Type II). Argatroban consists of a
mixture of R and S stereoisomers at a ratio of approximately 65:35.
The molecular formula of Argatroban is C23H36N6O5SH2O. Its molecular weight is 526.66.
The structural formula is shown below:
Argatroban is a white, odorless crystalline powder that is freely soluble in glacial acetic acid,
slightly soluble in ethanol, and insoluble in acetone, ethyl acetate, and ether. Argatroban
Injection is a sterile clear, colorless to pale yellow, slightly viscous solution. Argatroban is
available in 250-mg (in 2.5-mL) single-use amber vials, with gray flip-top caps. Each mL of
sterile, nonpyrogenic solution contains 100 mg Argatroban. Inert ingredients: 750 mg D-sorbitol,
1,000 mg dehydrated alcohol.</P>
name for Argatroban is 1-[5-[(aminoiminomethyl)amino]-1-oxo-2-[[(1,2,3,4-tetrahydro-3-
methyl-8-quinolinyl)sulfonyl]amino]pentyl]-4-methyl-2-piperidinecarboxylic acid, monohydrate.
Argatroban has 4 asymmetric carbons. One of the asymmetric carbons has an R configuration
(stereoisomer Type I) and an S configuration (stereoisomer Type II). Argatroban consists of a
mixture of R and S stereoisomers at a ratio of approximately 65:35.
The molecular formula of Argatroban is C23H36N6O5SH2O. Its molecular weight is 526.66.
The structural formula is shown below:
Argatroban is a white, odorless crystalline powder that is freely soluble in glacial acetic acid,
slightly soluble in ethanol, and insoluble in acetone, ethyl acetate, and ether. Argatroban
Injection is a sterile clear, colorless to pale yellow, slightly viscous solution. Argatroban is
available in 250-mg (in 2.5-mL) single-use amber vials, with gray flip-top caps. Each mL of
sterile, nonpyrogenic solution contains 100 mg Argatroban. Inert ingredients: 750 mg D-sorbitol,
1,000 mg dehydrated alcohol.</P>
