No such thing. It's an old school idea that receptors down regulate while cycling or doing TRT. What's actually happening to make people think this is a rise in SHBG. SHBG binds with T and lowers your Free T. In the past this made people think they were saturating (or whatever) their receptors. If you combat SHBG to a lower level with Proviron or a few other things, you get more bang for your buck with a rise in Free T.
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