Only if you didn't put those calories to use. The pancreas gets stressed from having to play keep up when insulin resistance sets in. The biggest cause of insulin resistance? Obesity.
However, if you put on a great deal of lean mass, it would consume calories continuously - which actually benefits your glycemic response.
This is assuming we're talking about a healthy individual that isn't on certain drugs/hormones that induce insulin resistance like HGH or corticosteroids/glucosteroids.
My .02c