castillian
struggle
Cad deca affect a psa test ? That is push it up to levels of concern ?
Can Deca Affect A Psa Test ?
- Thread starter castillian
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BigRonWannabee
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Movin it to anabolic forum for ya...
blue_pill
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no definite paper in the literature to say it does or doesn't-
so lets look at how the prostate grows:
Testosterone acts at the androgen receptor in the prostate and induces among other things cellular proliferation which results in your prostate growing. When testosterone is acted on by 5-alpha reductse dihydrotestosterone is prodcuced which has an even greater affinity for the androgen receptor and can induce even greater cellular proliferation. This is why 5-alpha reducatse inhibitors are good for preventing prostate growth and hair loss when using testosterone.
Nandrolone on the other hand is converted to Nor-DHT by 5 alpha reductase and its affinity for the androgen receptor is reduced and hence should have less of a tendency to cause prostate growth and hair loss.
5 Alpha-reductase is only present in certain tissues e.g. hair follicles and prostate tissue so this action of 5-alpha doesn't prevent the anabolic effect of Nandrolone on muscle.
So from the bits of the literature that look at metabolism of nandrolone- it should cause less prostate growth and hence is less likely to artificially raise blood PSA levels.
Bottom line from a urological perspective is that if you have prostate symptoms or a raised PSA you need to see a urologist for a full diagnostic work-up. IF caught early prostate cancer is curable.
key reference:
J Steroid Biochem Mol Biol. 1995 Jun;53(1-6):253-7.
Different patterns of metabolism determine the relative anabolic activity of 19-norandrogens.
Sundaram K, Kumar N, Monder C, Bardin CW.
so lets look at how the prostate grows:
Testosterone acts at the androgen receptor in the prostate and induces among other things cellular proliferation which results in your prostate growing. When testosterone is acted on by 5-alpha reductse dihydrotestosterone is prodcuced which has an even greater affinity for the androgen receptor and can induce even greater cellular proliferation. This is why 5-alpha reducatse inhibitors are good for preventing prostate growth and hair loss when using testosterone.
Nandrolone on the other hand is converted to Nor-DHT by 5 alpha reductase and its affinity for the androgen receptor is reduced and hence should have less of a tendency to cause prostate growth and hair loss.
5 Alpha-reductase is only present in certain tissues e.g. hair follicles and prostate tissue so this action of 5-alpha doesn't prevent the anabolic effect of Nandrolone on muscle.
So from the bits of the literature that look at metabolism of nandrolone- it should cause less prostate growth and hence is less likely to artificially raise blood PSA levels.
Bottom line from a urological perspective is that if you have prostate symptoms or a raised PSA you need to see a urologist for a full diagnostic work-up. IF caught early prostate cancer is curable.
key reference:
J Steroid Biochem Mol Biol. 1995 Jun;53(1-6):253-7.
Different patterns of metabolism determine the relative anabolic activity of 19-norandrogens.
Sundaram K, Kumar N, Monder C, Bardin CW.
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