Austinite
Moderator
Introduction
Prostate health in men is often dismissed or overlooked. Lots of folks are working towards healthy blood counts and liver values, but the fact is that your prostate gland is highly affected. This may not be a big deal to you, but a lot of concern will be raised once you understand your prostate's purposes and the negative effects it can cause. Hopefully this article will serve to educate you further, and you'll be able to make a much more informed decision on how you handle your future cycles.
What Exactly is the Prostate?
Opposite of endocrine glands, this is an exocrine gland; such as the liver and adrenal glands. It's part of your reproductive system and it sits just under your bladder. The main reason this gland exists is to enhance the quality of sperm by secreting Prostate Specific Antigen fluids (PSA). The alkaline content in the fluids it produced in ejaculate protects the sperm because vaginal areas are acidic and can damage sperm. All the nerves that affect male erections wrap around the prostate.
As mentioned earlier, the penile nerves are surrounding the prostate. These are the nerves that control our erections. Another reason to keep a healthy prostate because an unhealthy prostate could damage these nerves, inevitably leading to erectile dysfunction. Furthermore, being an actual muscle, it also controls the force of which your ejaculate content exits. A weak ejaculate would be an indication of a weak muscle. This is a "pumping" type action and it's the reason males feel "good" at the climax point.
Kind of like the liver, it also acts as a filter to make sure your sperm stays healthy. Toxins can reach the prostate just like anything else, and the prostate will filter these toxins out. This is not only important for the sake of healthy sperm, but overall health as well because if filtration is hindered due to an unhealthy prostate, big complications can occur such as prostate cancer.
Urinary infections are more likely in women than it is in men, but it's still possible and these infections start with an unhealthy prostate. Speaking of urinary issues, the prostate has 2 muscles called the "Sphincter" muscles. These exit to control the release of ejaculate and urine, where it literally turn valves on and off so that they are not released simultaneously.
So that's your prostate and it's functions. Let's look at how steroids affect your prostate...
How Anabolic Steroids Negatively Affect Your Prostate
Earlier we mentioned that the prostate is a muscle. Continuous steroid use will eventually enlarge the prostate, as it would with anything else. This isn't a drastic increase but certainly something to consider if you plan on using anabolic steroids for extended periods. The truth is, as you age, your prostate will get bigger. This is why folks over 40 are always recommended to get it checked periodically. But there are some precautions we can take to delay this process as much as possible.
Here's a quick study on an athlete that was using anabolic steroids and volunteered himself for this study. Please note that in the medical industry, any use of steroids that is not done under a doctors care is considered abuse. So don't let the word "abuse" scare you as it does not mean he was injecting several grams of anabolic steroids.
STUDY: PMID: 7529633
Steroid abuse in athletes, prostatic enlargement and bladder outflow obstruction.
OBJECTIVE:
To evaluate the effects of exogenous androgenic-anabolic steroids on the human prostate gland.
SUBJECT AND METHODS:
A white male athlete, who was routinely using anabolic steroids, volunteered for the study. He was studied during a 15-week period of steroid self-administration. Both objective and subjective parameters were measured, including: prostatic volume (transrectal ultrasound), digital rectal examination, urine flow rate, serum acid phosphatase and prostate specific antigen, symptom scoring for bladder outflow obstruction and other associated symptoms.
RESULTS:
During the period of steroid self-administration, prostatic volume increased and urine flow rate decreased. The man also noticed an increase in nocturnal urinary frequency, libido and aggression.
CONCLUSION:
In this pilot study, the administration of exogenous androgenic-anabolic steroids has been demonstrated to have profound effects on the human prostate gland, including an increase in prostatic volume, reduction in urine flow rate and an alteration in voiding patterns. These findings warrant further investigation.
Now, some folks might object to some of the side effects from exogenous testosterone, however, the majority of the studies done (all that I have seen) compared endogenous testosterone serum, not exogenous. So they're really not a fair assessment considering your natural production is generally balanced. By balanced, I don't mean that your levels are in range. What I mean is that your body has become accustomed to the level and adapted to operate functionally. In other words, your prostate doesn't really freak out with different natural testosterone levels.
What are Signs of Prostate Related Problems
You can look for certain signs that might indicate either an enlarged prostate and/or other underlying issues and concerns. This is mostly noticeable in your urine. Below you will find a list of common observations you can use to make a decision on whether you need to get your prostate checked:
- Involuntary urination
- Unable to urinate
- Painful urination
- Blood in urine
- Very weak stream
- Waking up several times to urinate
The most common of the symptoms I mentioned above is the weak urine stream. So keep an eye on that. As for a painful urinary experience, you are likely to have some sort of infection. A CBC panel can sometimes identify an infection by observing your White Blood Cell (WBC) levels. If these are out of range, either too high or too low, would indicate that your body is fighting an infection.
What is the Process of Testing the Prostate?
There are several methods used to test the health of your prostate. Your doctor is likely to first order either blood work or a urinalysis. The following are common methods of testing the prostate:
Prostate Specific Antigen test. (PSA test)
-- This is done via a blood sample, and can identify abnormalities and cancer. I get this test several times per year.
Checking urine flow
-- Simple test of observing flow to see if it's strong, or weak where it would indicate an issue with fow.
Urinalysis & Urine Culture
-- A urine sample is analyzed for identifying any traces of blood and to check for infections under a microscope.
Cystoscopy
-- A telescope is used to observe the inside of your bladder.
Rectal exam
-- The one we hate the most. Doctor inserts gloved finger in your rectum to feel if prostate is enlarged.
What Can I do to Prevent or Delay Complications?
For most of us, if we do in fact have an enlarged prostate, it's more than likely a mild case. Sometimes not noticeable symptoms until it gets worse. But as promised, I'll give you some pointers to either reduce the enlargement and/or prevent and delay it.
- Minimize alcohol and caffeine intake.
- Avoid antihistamines.
- Don't allow your body temperature to drop.
- Avoid large water intake in one sitting.
Supplementations you can use to help with this condition:
I know lot's of folks, or thousands rather, use Saw Palmetto for reversing an enlarged prostate. Frankly, I don't see anything in saw palmetto that can aid with this condition. There have been both, positive and negative studies. There just isn't enough evidence to conclude its effectiveness.
CIALIS! Although not over the counter, it's certainly readily available. Cialis is your best friend and will help you maintain a healthy prostate. If your PSA comes back high, Cialis can bring it down in a matter of weeks. It helps relax the muscle, too so it's not stressed or "under pressure". 5 mg a day at least is what I recommend. I personally take 10mg a day.
I also recommend that you use Nettle Root Extract. This is an herb that can most certainly assist in prostate and urine flow obstruction related issues. For everyday use I recommend 500mg twice daily, for a total of 1 gram per day. In the event that you have any abnormalities, I would double that dose to 2 grams per day total.
Furthermore on supplementations, I also recommend that you incorporate a minimum of 3 grams of vitamin C daily, 30 mg of zinc and introduce green tea into your daily liquid intake. Following these supplemental guidelines will certainly help with your urine flow and reduce swelling to a degree. If you looked at my supplement protocol, you'll notice that I already use all of these as part of my daily regimen. If you see nettle root missing from my protocol, it's because I drink Tisane tea, which is heavy with nettle.
TADALAFIL (CIALIS)
Tadalafil (Cialis) has been mentioned quite a bit recently on the forums. This is by far, one of my favorite drugs available today. When we hear of Cialis, generally we think of a pill for erectile dysfunction. This is true, as that was its initial purpose. However, over the years, Cialis has been proven to provide aid and health in many areas. Today we'l be discussing Cialis and all of its benefits. So let's get started...
What is Cialis and how does it work?
Cialis is a phosphodiesterase type 5 (PDE5) inhibitor. Phosphodiesterase (PDE) are different enzymes in our bodies that all come together and make up chemicals in the phosphate group (salts). Of all the PDE's in our bodies, it is the type 5 PDE that is of concern to us in regards to this topic. While dominant in PDE5 inhibition, it also inhibits PDE6.
Stay with me here, this isn't easy to explain...
Type 5 PDE breaks down and damages cyclic guanosine monophosphate (cGMP), which basically activates intracellular protein enzymes that regulate all of our cell pathways. These pathways are for signaling the activation of receptor proteins. This activation causes relaxation in the "smooth muscle" in the corpus cavernosum (inside the penis) and dilates the vessels leading up to it. Are you still with me or did I lose you?
So to sum it all up, PDE5 is damaging to everything that our bodies need to generate an erection. By blocking PDE5, our body has the opportunity to function without disruption. That's why PDE5 inhibitors were invented. Like Cialis and Viagra. They block PDE5 and that enables us to have erections again.
As you get older, you accumulate more and more PDE5 and/or cGMP diminishes. This is why it's common for older folks to experience impotence. Sometimes even in the presence of normal serum testosterone levels. In some cases, cGMP production diminishes, and that's why Cialis and other PDE5 inhibitors do not work very well in some folks. These folks would have to use more extreme measure, such as Trimix; the penile injection.
What else can Cialis do for me?
NITRIC OXIDE: One of the results of cGMP is to cause a chemical reaction with the nitric oxide synthase enzyme. This generates Nitric Oxide that increases the circumference of our vessels. Not only in and around the penis, but all over our bodies. This is what causes vascularity and gives you an incredible "pump" after a resistance training session. Nitric oxide has a very short life, so constant production is very important. It's great for the betterment of your cardiovascular system by increasing blood flow. By increasing Nitric Oxide levels, your blood is now flowing much better. This results in better oxygen delivery and other nutrients to your muscles and other tissue. Of course, the more nutrients they receive the healthier they will be.
LOWER BLOOD PRESSURE: This drug will lower your blood pressure. This is not a drastic or dangerous decrease in blood pressure. Just enough to make it HIGHLY recommended for use during our steroid cycles. It is important to note that you should not use blood pressure medication while on Cialis. Unless of course, approved by your doctor. But generally, ACE inhibitors, alpha blockers and other forms are not recommended for coupling with Cialis.
PROSTATE HEALTH: Cialis has been approved to treat enlarged prostates. In studies, they used as little as 5 mg daily to reduce inflammation of the prostate and bringing back to a normal state.
STUDY: PMID: 23782459
Effects of Tadalafil on Lower Urinary Tract Symptoms Secondary to Benign Prostatic Hyperplasia and on Erectile Dysfunction in Sexually Active Men with Both Conditions: Analyses of Pooled Data from Four Randomized, Placebo-Controlled Tadalafil Clinical Studies.
INTRODUCTION:
Erectile dysfunction (ED) and lower urinary tract symptoms suggestive of benign prostatic hyperplasia (LUTS/BPH) are common in aging males and frequently occur together. Tadalafil has demonstrated efficacy in treating both conditions.
AIM:
The study aims to evaluate the efficacy and safety of tadalafil 5***8201;mg once daily vs. placebo over 12 weeks in treating both LUTS/BPH and ED in sexually active men. We also assessed relationships of baseline disease severity and prostate specific antigen (PSA) to outcomes.
METHODS:
Data were pooled from four multinational, randomized studies of men ***8805;45 years with LUTS/BPH, with analyses restricted to sexually active men with ED. Randomization (baseline) followed a 4-week placebo run-in; changes from baseline were assessed vs. placebo using analysis of covariance.
MAIN OUTCOME MEASURES:
International Prostate Symptom Score (IPSS), IPSS subscores, Quality-of-Life Index (IPSS-QoL), BPH Impact Index (BII), and International Index of Erectile Function-Erectile Function (IIEF-EF) Domain score were used in this study.
RESULTS:
Tadalafil (N***8201;=***8201;505) significantly improved total IPSS vs. placebo (N***8201;=***8201;521); mean changes from baseline were -6.0 and -3.6, respectively (P***8201;<***8201;0.001). Improvements in IIEF-EF Domain score (tadalafil, 6.4; placebo, 1.4) were also significant vs. placebo, as were the IPSS storage and voiding subscores, IPSS-QoL, and BII (all P***8201;<***8201;0.001). No significant impact of baseline ED severity or PSA category on IPSS response was observed (interaction P values, 0.463 and 0.149, respectively). Similarly, improvement in IIEF-EF Domain score was not significantly impacted by baseline LUTS/BPH severity or PSA category (interaction P values, 0.926 and 0.230, respectively). Improvements in IPSS and IIEF-EF Domain score during treatment were weakly correlated (r***8201;=***8201;-0.229). Treatment-emergent adverse events were consistent with previous reports.
CONCLUSIONS:
Tadalafil was efficacious and well tolerated in treating ED and LUTS/BPH in sexually active men with both conditions. Improvements in both conditions were significant regardless of baseline severity. Improvements in the total IPSS and the IIEF-EF Domain score were weakly correlated.
As mentioned in the study above, Cialis can treat benign prostatic hyperplasia (BPH). This FDA approved. Click here to see the release...
How does Cialis compare to Viagra?
Cialis is far superior than Viagra. Viagra is fairly short lived, where the effects diminish in a matter of hours. Furthermore, Viagra can cause constant erection so long as it's in your system. This may sound good for some, but for me that can be quite annoying. Imagine lifting at the gym and suddenly you become erect. I'd rather come to an erection when stimulated only. Which is what Cialis does. The good news is, that once you climax/ejaculate, you'll be able to perform once again very shortly after. This is due to it's long half life.
STUDY: PMID: 15709885
Comparison of clinical trials with sildenafil, vardenafil and tadalafil in erectile dysfunction.
Abstract
Erectile dysfunction (ED) affects up to 50% of men, between 40 and 70 years of age. In the first major trial of sildenafil in ED, at 24 weeks, improved erections were reported by 77 and 84% of men taking sildenafil 50 and 100mg, respectively. Subsequently, sildenafil has been reported to be effective in men with ED associated with diabetes and prostate cancer, and in psychogenic ED. Sildenafil is safe in men with coronary artery disease, provided it is not used with the nitrates (a contraindication). The most commonly reported adverse effects with sildenafil are headache, flushing and dyspepsia.
Vardenafil is more potent and more selective than sildenafil at inhibiting phosphodiesterase-5. Vardenafil is similarly effective to sildenafil in the treatment of ED. The only advantage that vardenafil has over sildenafil is that it does not inhibit phosphodiesterase-6 to alter colour perception, a rare side effect which sometimes occurs with sildenafil. Tadalafil has a longer duration of action than sildenafil and vardenafil. Tadalafil is similarly effective as sildenafil in the treatment of ED. In comparison studies, tadalafil is preferred to sildenafil (50/100mg) by men with ED, possibly because of its longer duration of action. Of the phosphodiesterase inhibitors, tadalafil may displace sildenafil as the drug of choice among men with ED.
Austinite's dosage and protocol recommendation:
My personal protocol is 5 mg administered twice daily; for a total of 10 mg per day. There is no reason to split the dose up, however, the reason I split is because I only want 5 mg as part of my pre workout.
- If you're under 30 years of age. I recommend 5 mg daily.
- If you're over 30 years of age, I recommend 10 mg daily.
Anyone under 18 should not be using this drug and frankly, teenagers don't need it.
That's all I have for you. Have a powerful day,
~ Austinite
Prostate health in men is often dismissed or overlooked. Lots of folks are working towards healthy blood counts and liver values, but the fact is that your prostate gland is highly affected. This may not be a big deal to you, but a lot of concern will be raised once you understand your prostate's purposes and the negative effects it can cause. Hopefully this article will serve to educate you further, and you'll be able to make a much more informed decision on how you handle your future cycles.
What Exactly is the Prostate?
Opposite of endocrine glands, this is an exocrine gland; such as the liver and adrenal glands. It's part of your reproductive system and it sits just under your bladder. The main reason this gland exists is to enhance the quality of sperm by secreting Prostate Specific Antigen fluids (PSA). The alkaline content in the fluids it produced in ejaculate protects the sperm because vaginal areas are acidic and can damage sperm. All the nerves that affect male erections wrap around the prostate.
As mentioned earlier, the penile nerves are surrounding the prostate. These are the nerves that control our erections. Another reason to keep a healthy prostate because an unhealthy prostate could damage these nerves, inevitably leading to erectile dysfunction. Furthermore, being an actual muscle, it also controls the force of which your ejaculate content exits. A weak ejaculate would be an indication of a weak muscle. This is a "pumping" type action and it's the reason males feel "good" at the climax point.
Kind of like the liver, it also acts as a filter to make sure your sperm stays healthy. Toxins can reach the prostate just like anything else, and the prostate will filter these toxins out. This is not only important for the sake of healthy sperm, but overall health as well because if filtration is hindered due to an unhealthy prostate, big complications can occur such as prostate cancer.
Urinary infections are more likely in women than it is in men, but it's still possible and these infections start with an unhealthy prostate. Speaking of urinary issues, the prostate has 2 muscles called the "Sphincter" muscles. These exit to control the release of ejaculate and urine, where it literally turn valves on and off so that they are not released simultaneously.
So that's your prostate and it's functions. Let's look at how steroids affect your prostate...
How Anabolic Steroids Negatively Affect Your Prostate
Earlier we mentioned that the prostate is a muscle. Continuous steroid use will eventually enlarge the prostate, as it would with anything else. This isn't a drastic increase but certainly something to consider if you plan on using anabolic steroids for extended periods. The truth is, as you age, your prostate will get bigger. This is why folks over 40 are always recommended to get it checked periodically. But there are some precautions we can take to delay this process as much as possible.
Here's a quick study on an athlete that was using anabolic steroids and volunteered himself for this study. Please note that in the medical industry, any use of steroids that is not done under a doctors care is considered abuse. So don't let the word "abuse" scare you as it does not mean he was injecting several grams of anabolic steroids.
STUDY: PMID: 7529633
Steroid abuse in athletes, prostatic enlargement and bladder outflow obstruction.
OBJECTIVE:
To evaluate the effects of exogenous androgenic-anabolic steroids on the human prostate gland.
SUBJECT AND METHODS:
A white male athlete, who was routinely using anabolic steroids, volunteered for the study. He was studied during a 15-week period of steroid self-administration. Both objective and subjective parameters were measured, including: prostatic volume (transrectal ultrasound), digital rectal examination, urine flow rate, serum acid phosphatase and prostate specific antigen, symptom scoring for bladder outflow obstruction and other associated symptoms.
RESULTS:
During the period of steroid self-administration, prostatic volume increased and urine flow rate decreased. The man also noticed an increase in nocturnal urinary frequency, libido and aggression.
CONCLUSION:
In this pilot study, the administration of exogenous androgenic-anabolic steroids has been demonstrated to have profound effects on the human prostate gland, including an increase in prostatic volume, reduction in urine flow rate and an alteration in voiding patterns. These findings warrant further investigation.
Now, some folks might object to some of the side effects from exogenous testosterone, however, the majority of the studies done (all that I have seen) compared endogenous testosterone serum, not exogenous. So they're really not a fair assessment considering your natural production is generally balanced. By balanced, I don't mean that your levels are in range. What I mean is that your body has become accustomed to the level and adapted to operate functionally. In other words, your prostate doesn't really freak out with different natural testosterone levels.
What are Signs of Prostate Related Problems
You can look for certain signs that might indicate either an enlarged prostate and/or other underlying issues and concerns. This is mostly noticeable in your urine. Below you will find a list of common observations you can use to make a decision on whether you need to get your prostate checked:
- Involuntary urination
- Unable to urinate
- Painful urination
- Blood in urine
- Very weak stream
- Waking up several times to urinate
The most common of the symptoms I mentioned above is the weak urine stream. So keep an eye on that. As for a painful urinary experience, you are likely to have some sort of infection. A CBC panel can sometimes identify an infection by observing your White Blood Cell (WBC) levels. If these are out of range, either too high or too low, would indicate that your body is fighting an infection.
What is the Process of Testing the Prostate?
There are several methods used to test the health of your prostate. Your doctor is likely to first order either blood work or a urinalysis. The following are common methods of testing the prostate:
Prostate Specific Antigen test. (PSA test)
-- This is done via a blood sample, and can identify abnormalities and cancer. I get this test several times per year.
Checking urine flow
-- Simple test of observing flow to see if it's strong, or weak where it would indicate an issue with fow.
Urinalysis & Urine Culture
-- A urine sample is analyzed for identifying any traces of blood and to check for infections under a microscope.
Cystoscopy
-- A telescope is used to observe the inside of your bladder.
Rectal exam
-- The one we hate the most. Doctor inserts gloved finger in your rectum to feel if prostate is enlarged.
What Can I do to Prevent or Delay Complications?
For most of us, if we do in fact have an enlarged prostate, it's more than likely a mild case. Sometimes not noticeable symptoms until it gets worse. But as promised, I'll give you some pointers to either reduce the enlargement and/or prevent and delay it.
- Minimize alcohol and caffeine intake.
- Avoid antihistamines.
- Don't allow your body temperature to drop.
- Avoid large water intake in one sitting.
Supplementations you can use to help with this condition:
I know lot's of folks, or thousands rather, use Saw Palmetto for reversing an enlarged prostate. Frankly, I don't see anything in saw palmetto that can aid with this condition. There have been both, positive and negative studies. There just isn't enough evidence to conclude its effectiveness.
CIALIS! Although not over the counter, it's certainly readily available. Cialis is your best friend and will help you maintain a healthy prostate. If your PSA comes back high, Cialis can bring it down in a matter of weeks. It helps relax the muscle, too so it's not stressed or "under pressure". 5 mg a day at least is what I recommend. I personally take 10mg a day.
I also recommend that you use Nettle Root Extract. This is an herb that can most certainly assist in prostate and urine flow obstruction related issues. For everyday use I recommend 500mg twice daily, for a total of 1 gram per day. In the event that you have any abnormalities, I would double that dose to 2 grams per day total.
Furthermore on supplementations, I also recommend that you incorporate a minimum of 3 grams of vitamin C daily, 30 mg of zinc and introduce green tea into your daily liquid intake. Following these supplemental guidelines will certainly help with your urine flow and reduce swelling to a degree. If you looked at my supplement protocol, you'll notice that I already use all of these as part of my daily regimen. If you see nettle root missing from my protocol, it's because I drink Tisane tea, which is heavy with nettle.
TADALAFIL (CIALIS)
Tadalafil (Cialis) has been mentioned quite a bit recently on the forums. This is by far, one of my favorite drugs available today. When we hear of Cialis, generally we think of a pill for erectile dysfunction. This is true, as that was its initial purpose. However, over the years, Cialis has been proven to provide aid and health in many areas. Today we'l be discussing Cialis and all of its benefits. So let's get started...
What is Cialis and how does it work?
Cialis is a phosphodiesterase type 5 (PDE5) inhibitor. Phosphodiesterase (PDE) are different enzymes in our bodies that all come together and make up chemicals in the phosphate group (salts). Of all the PDE's in our bodies, it is the type 5 PDE that is of concern to us in regards to this topic. While dominant in PDE5 inhibition, it also inhibits PDE6.
Stay with me here, this isn't easy to explain...
Type 5 PDE breaks down and damages cyclic guanosine monophosphate (cGMP), which basically activates intracellular protein enzymes that regulate all of our cell pathways. These pathways are for signaling the activation of receptor proteins. This activation causes relaxation in the "smooth muscle" in the corpus cavernosum (inside the penis) and dilates the vessels leading up to it. Are you still with me or did I lose you?
So to sum it all up, PDE5 is damaging to everything that our bodies need to generate an erection. By blocking PDE5, our body has the opportunity to function without disruption. That's why PDE5 inhibitors were invented. Like Cialis and Viagra. They block PDE5 and that enables us to have erections again.
As you get older, you accumulate more and more PDE5 and/or cGMP diminishes. This is why it's common for older folks to experience impotence. Sometimes even in the presence of normal serum testosterone levels. In some cases, cGMP production diminishes, and that's why Cialis and other PDE5 inhibitors do not work very well in some folks. These folks would have to use more extreme measure, such as Trimix; the penile injection.
What else can Cialis do for me?
NITRIC OXIDE: One of the results of cGMP is to cause a chemical reaction with the nitric oxide synthase enzyme. This generates Nitric Oxide that increases the circumference of our vessels. Not only in and around the penis, but all over our bodies. This is what causes vascularity and gives you an incredible "pump" after a resistance training session. Nitric oxide has a very short life, so constant production is very important. It's great for the betterment of your cardiovascular system by increasing blood flow. By increasing Nitric Oxide levels, your blood is now flowing much better. This results in better oxygen delivery and other nutrients to your muscles and other tissue. Of course, the more nutrients they receive the healthier they will be.
LOWER BLOOD PRESSURE: This drug will lower your blood pressure. This is not a drastic or dangerous decrease in blood pressure. Just enough to make it HIGHLY recommended for use during our steroid cycles. It is important to note that you should not use blood pressure medication while on Cialis. Unless of course, approved by your doctor. But generally, ACE inhibitors, alpha blockers and other forms are not recommended for coupling with Cialis.
PROSTATE HEALTH: Cialis has been approved to treat enlarged prostates. In studies, they used as little as 5 mg daily to reduce inflammation of the prostate and bringing back to a normal state.
STUDY: PMID: 23782459
Effects of Tadalafil on Lower Urinary Tract Symptoms Secondary to Benign Prostatic Hyperplasia and on Erectile Dysfunction in Sexually Active Men with Both Conditions: Analyses of Pooled Data from Four Randomized, Placebo-Controlled Tadalafil Clinical Studies.
INTRODUCTION:
Erectile dysfunction (ED) and lower urinary tract symptoms suggestive of benign prostatic hyperplasia (LUTS/BPH) are common in aging males and frequently occur together. Tadalafil has demonstrated efficacy in treating both conditions.
AIM:
The study aims to evaluate the efficacy and safety of tadalafil 5***8201;mg once daily vs. placebo over 12 weeks in treating both LUTS/BPH and ED in sexually active men. We also assessed relationships of baseline disease severity and prostate specific antigen (PSA) to outcomes.
METHODS:
Data were pooled from four multinational, randomized studies of men ***8805;45 years with LUTS/BPH, with analyses restricted to sexually active men with ED. Randomization (baseline) followed a 4-week placebo run-in; changes from baseline were assessed vs. placebo using analysis of covariance.
MAIN OUTCOME MEASURES:
International Prostate Symptom Score (IPSS), IPSS subscores, Quality-of-Life Index (IPSS-QoL), BPH Impact Index (BII), and International Index of Erectile Function-Erectile Function (IIEF-EF) Domain score were used in this study.
RESULTS:
Tadalafil (N***8201;=***8201;505) significantly improved total IPSS vs. placebo (N***8201;=***8201;521); mean changes from baseline were -6.0 and -3.6, respectively (P***8201;<***8201;0.001). Improvements in IIEF-EF Domain score (tadalafil, 6.4; placebo, 1.4) were also significant vs. placebo, as were the IPSS storage and voiding subscores, IPSS-QoL, and BII (all P***8201;<***8201;0.001). No significant impact of baseline ED severity or PSA category on IPSS response was observed (interaction P values, 0.463 and 0.149, respectively). Similarly, improvement in IIEF-EF Domain score was not significantly impacted by baseline LUTS/BPH severity or PSA category (interaction P values, 0.926 and 0.230, respectively). Improvements in IPSS and IIEF-EF Domain score during treatment were weakly correlated (r***8201;=***8201;-0.229). Treatment-emergent adverse events were consistent with previous reports.
CONCLUSIONS:
Tadalafil was efficacious and well tolerated in treating ED and LUTS/BPH in sexually active men with both conditions. Improvements in both conditions were significant regardless of baseline severity. Improvements in the total IPSS and the IIEF-EF Domain score were weakly correlated.
As mentioned in the study above, Cialis can treat benign prostatic hyperplasia (BPH). This FDA approved. Click here to see the release...
How does Cialis compare to Viagra?
Cialis is far superior than Viagra. Viagra is fairly short lived, where the effects diminish in a matter of hours. Furthermore, Viagra can cause constant erection so long as it's in your system. This may sound good for some, but for me that can be quite annoying. Imagine lifting at the gym and suddenly you become erect. I'd rather come to an erection when stimulated only. Which is what Cialis does. The good news is, that once you climax/ejaculate, you'll be able to perform once again very shortly after. This is due to it's long half life.
STUDY: PMID: 15709885
Comparison of clinical trials with sildenafil, vardenafil and tadalafil in erectile dysfunction.
Abstract
Erectile dysfunction (ED) affects up to 50% of men, between 40 and 70 years of age. In the first major trial of sildenafil in ED, at 24 weeks, improved erections were reported by 77 and 84% of men taking sildenafil 50 and 100mg, respectively. Subsequently, sildenafil has been reported to be effective in men with ED associated with diabetes and prostate cancer, and in psychogenic ED. Sildenafil is safe in men with coronary artery disease, provided it is not used with the nitrates (a contraindication). The most commonly reported adverse effects with sildenafil are headache, flushing and dyspepsia.
Vardenafil is more potent and more selective than sildenafil at inhibiting phosphodiesterase-5. Vardenafil is similarly effective to sildenafil in the treatment of ED. The only advantage that vardenafil has over sildenafil is that it does not inhibit phosphodiesterase-6 to alter colour perception, a rare side effect which sometimes occurs with sildenafil. Tadalafil has a longer duration of action than sildenafil and vardenafil. Tadalafil is similarly effective as sildenafil in the treatment of ED. In comparison studies, tadalafil is preferred to sildenafil (50/100mg) by men with ED, possibly because of its longer duration of action. Of the phosphodiesterase inhibitors, tadalafil may displace sildenafil as the drug of choice among men with ED.
Austinite's dosage and protocol recommendation:
My personal protocol is 5 mg administered twice daily; for a total of 10 mg per day. There is no reason to split the dose up, however, the reason I split is because I only want 5 mg as part of my pre workout.
- If you're under 30 years of age. I recommend 5 mg daily.
- If you're over 30 years of age, I recommend 10 mg daily.
Anyone under 18 should not be using this drug and frankly, teenagers don't need it.
That's all I have for you. Have a powerful day,
~ Austinite
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