Do you think one of them is using gear pt. 2

How does testosterone replacement therapy (TRT) shut down thyroid function?

What can be done to prevent it?
 
DreDay187 said:
Bc ch**ese is FUCKING NASTY and by extension ch**secake is FUCKING NASTIER...or just as nasty.
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I don't think I've ever met anyone that doesn't like cheese before. There is something seriously wrong with you. Cheesecake is what I would imagine Jesus' cum to taste like.
 
People who were out on T3 for years mistakenly and came off restored natural THYROID function after a week or two I believe.
 
CptFKNplanet said:
I don't think I've ever met anyone that doesn't like cheese before. There is something seriously wrong with you. Cheesecake is what I would imagine Jesus' cum to taste like.
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The fact that you're making such an analogy is proof positive its you who's messed up lmao. I fucking HATE it and even avoid walking down that aisle at the grocery store. If I touch it inadvertently I wash my hands with dilute bleach.
 
71Avido said:
How does testosterone replacement therapy (TRT) shut down thyroid function?

What can be done to prevent it?
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Romeo Mariano said:
Usually, when I start testosterone replacement therapy (TRT), I also have to be ready to adjust thyroid hormone because exogenous testosterone can reduce thyroid signaling.

Changing one signal (as in testosterone) causes multiple downstream signaling changes in other systems. As long as one is ready to make the adjustments to thyroid hormone signaling and other signaling systems with testosterone replacement therapy (TRT) (such as estrogen signaling, adrenal signaling, nervous system, immune system, metabolism, nutrition, etc.), then one can avoid some complications with testosterone replacement therapy (TRT), such as anxiety, fatigue, hypertension, insomnia, body aches, etc.

Off the top of my head, there are several possible ways testosterone replacement therapy (TRT) can reduce thyroid hormone signaling, including the following:

1. Exogenous testosterone suppresses testicular testosterone production AND testicular thyroid releasing hormone (TRH) production. This reduces brain TSH production, lowering thyroid hormone production from the thyroid gland.

2. Exogenous testosterone may reduce liver production of thyroid binding globulin. This reduces the half-life of thyroid hormone. This leads to a reduction in available thyroid hormone.

3. Exogenous testosterone can lead to a simultaneous conversion of testosterone to estradiol. The increase in estradiol can increase liver production of thyroid binding globulin. This can lead to a reduction in free thyroid hormone levels (Free T3, Free T4). This then reduces thyroid signaling.

4. Exogenous Human Chorionic Gonadotropin (HCG) (human chorionic gonadotropin) not only increases testicular production of testosterone and sperm but also increases aromatase enzyme production. The increase in aromatase enzyme can then lead to an increase in estradiol production from testosterone. This (as noted above) can lead to a reduction in thyroid signaling.

5. Exogenous testosterone can suppress ACTH (adrenocorticotropic hormone) production from the brain. And it can directly suppress adrenal cortical activity, including cortisol production. This can then lead to an increase in norepinephrine production, then immune system inflammatory signaling. This can then shift thyroid metabolism so that T4 is converted to reverse T3 (the waste product pathway) instead of being converted to T3 (the active thyroid hormone). This can reduce both T4 levels and T3 levels, leading to a reduction in thyroid signaling.

When possible, I usually prefer to consider first optimizing thyroid signaling, adrenal function, immune system function, nervous system function, metabolism and nutrition, to allow a smoother transition to testosterone replacement therapy.

There are times when adding testosterone simultaneously while addressing the other systems is important to help break some positive feedback loops between systems that contribute to illness. For example, high insulin/insulin resistance/diabetes, obesity, inflammatory signaling, stress/norepinephrine signaling, and lower testosterone production can be involved in multiple positive feedback loops which can cause significant illness. Adding testosterone when it is low in such a person can help unravel the self-perpetuating signaling loops that keep a person ill.
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^
 
DreDay187 said:
The fact that you're making such an analogy is proof positive its you who's messed up lmao. I fucking HATE it and even avoid walking down that aisle at the grocery store. If I touch it inadvertently I wash my hands with dilute bleach.
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Are you telling me, you wouldn't suck the shit out of Jesus' penis? You're going to hell. Atheist scum!! REPENT!!!!!!!!
You're like the fuckin mustard man from CKY / Jackass. What's his name? Rake Yohn or some shit? If we ever meet in person I'm gonna get some of that spray can cheese shit and use it like silly string.
 
71Avido said:
Today, Dre is defending his stance on cheesecake.

lol.
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Defending it to the death lol. My family last year tried to poison me by not telling me they added ch**se to the mashed potatoes on Thanksgiving. I almost had a vasovagal syncope
 
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