Do you think one of them is using gear pt. 2

71Avido said:
Right, that much I know, what I'm asking and maybe I misunderstood your post was this:

Lets remove as many variables from the equation as possible (water, oxygen, temperature, accumulation in tissue, active metabolites, receptor interaction, renal function, liver function, enzyme inducers are all now constants)
For arguments sake lets just use 2 compounds with different half-lives entering that environment.
One with a half-life of 12 days, the other 4 hours.
What would cause one to decay faster than the other if their environmental conditions are the same?
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What you're trying to ask is why does say Cialis have a shorter half life than Xanax... put simply, correct? Given all storage factors being the same, and the compounds not being ingested but straight out of the lab.
 
CptFKNplanet said:
What you're trying to ask is why does say Cialis have a shorter half life than Xanax... put simply, correct? Given all storage factors being the same, and the compounds not being ingested but straight out of the lab.
Click to expand...

Pretty much, or why does test ethenate decay more quickly than cypionate.

I didn't want to get into specific compounds but more the general concept of what determines rate of decay in a controlled environment.
 
71Avido said:
Right, that much I know, what I'm asking and maybe I misunderstood your post was this:

Lets remove as many variables from the equation as possible (water, oxygen, temperature, accumulation in tissue, active metabolites, receptor interaction, renal function, liver function, enzyme inducers are all now constants)
For arguments sake lets just use 2 compounds with different half-lives entering that environment.
One with a half-life of 12 days, the other 4 hours.
What would cause one to decay faster than the other if their environmental conditions are the same?
Click to expand...

The mechanism of action or pharmonkinetic pathways utilized in the metabolism of each compound. Some use CYP3A4 enzyme others use CYP1A2 enzyme and there's lots more. Different drugs work through different pathways and get metabolized differently, partly due to the molecular weight as you mentioned.
 
DreDay187 said:
No, that's why there are many different kinds of half life: terminal/elimination, biological/active, shelf life, rate of decay of tissue, nuclear decay, etc.
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I think he's asking in the most basic sense. Like why does dbol have a shorter half life than tbol? Not that it does, just trying to put it in the most simple terms... even though it's not a simple question to answer lol.
 
71Avido said:
Pretty much, or why does test ethenate decay more quickly than cypionate.

I didn't want to get into specific compounds but more the general concept of what determines rate of decay in a controlled environment.
Click to expand...

That's what I thought.

I don't think you can really answer it without getting into the compound makeup of each specific compound though if that makes sense. You'd have to look at it on a molecular level to determine which elements decay faster or slower.
 
DreDay187 said:
The mechanism of action or pharmonkinetic pathways utilized in the metabolism of each compound. Some use CYP3A4 enzyme others use CYP1A2 enzyme and there's lots more. Different drugs work through different pathways and get metabolized differently, partly due to the molecular weight as you mentioned.
Click to expand...

That's what I was thinking.

That's the basis for different esters correct?
If you want a longer ester you use a compound that has less enzymes available to metabolize it?
 
DreDay187 said:
The mechanism of action or pharmonkinetic pathways utilized in the metabolism of each compound. Some use CYP3A4 enzyme others use CYP1A2 enzyme and there's lots more. Different drugs work through different pathways and get metabolized differently, partly due to the molecular weight as you mentioned.
Click to expand...

I think this is honestly the simplest way to explain it. Well put sir.

One off question... would certain compounds hold different half lives in different species? To keep it simple, same dose of the exact same test E given to a human and dog. Does the half life remain the same for both? Or would it be altered due to different speeds of metabolic rates? To further that question, everyone is different, so would half lives change from person to person? Even if a minuscule amount?
 
You see, I'm happy to just say the half life is what it is. It's just one more property of a compound, like boiling point, solubility and density. It just is what it is.
 
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