First Cycle Precautions?

[Kmaster15]

On my first cycle I plan on running Test E at 250mg every monday and thursday for 10 weeks and on week 11-12 take nothing and for post cycle therapy (pct) Arimidex week 13-16. Planning on running the Aromatase inhibitor (AI) through out the cycle but need proper dosage advice while on cycle and post cycle therapy (pct) for AI.

 

[Sardis23]

Adex should only be ran during the cycle. PCT should consist of clomid and nolva and maybe hcg.

 

[Vino 1]

http://www.steroidology.com/forum/a...-aromatize-inhibitors-gyno-pct-must-read.html
http://www.steroidology.com/forum/a...ycleing-beginners-guide-your-first-cycle.html
http://www.steroidology.com/forum/a...its-general-compound-info-noob-must-read.html

U should read more and start less threads.

 

[Docd187]

On my first cycle I plan on running Test E at 250mg every monday and thursday for 10 weeks and on week 11-12 take nothing and for PCT Arimidex week 13-16. Planning on running the Aromatase inhibitor (AI) through out the cycle but need proper dosage advice while on cycle and PCT for AI.

You should:

1) read, learn and research more (start with the links Vino1 posted)

2) think about extending length of test e cycle to 12wks (once you've done #1)

3) learn what an Aromatase inhibitor (AI) is, what it does, and when to take it

4) learn what SERMs are, what they do, and when to take them

5) redo #1 in case you've missed anything

 

[Kmaster15]

You should:

1) read, learn and research more (start with the links Vino1 posted)

2) think about extending length of test e cycle to 12wks (once you've done #1)

3) learn what an Aromatase inhibitor (AI) is, what it does, and when to take it

4) learn what SERMs are, what they do, and when to take them

5) redo #1 in case you've missed anything

Well i know that an Aromatase inhibitor (AI) is a aromatase inhibitor to prevent aromatization during cycle (prevent sides) and SERM is a estrogen receptor to keep estrogen low during natural testosterone recovery (PCT). Was just looking for a bit more detail, thanks for the great advice though.

 

[Docd187]

Well i know that an Aromatase inhibitor (AI) is a aromatase inhibitor to prevent aromatization during cycle (prevent sides) and SERM is a estrogen receptor to keep estrogen low during natural testosterone recovery (PCT). Was just looking for a bit more detail, thanks for the great advice though.

AIs not only prevent sides but they prevent the free testosterone in your system from being converted and wasted into estrogen. SERMs are receptor blockers but DO NOTHING to "keep estrogen low during natural testosterone recovery (PCT)".

For more detail: AIs are taken to stop the enzyme from creating estrogen or to stop the action of estrogen on the receptor (note this is not the same as blocking the receptor like nolva does). They help treat sides such as high BP, high estrogen, water weight/bloat, oily skin, etc. to be used on cycle leading up to post cycle therapy (pct).

SERMS:
Nolva is a mixed receptor agonist/antagonist. It is an antagonist in breast tissue where it blocks the estrogen receptor from binding with the aromatase enzyme. In other tissues its an agonist blocker meaning it does react biologically with the tissue. Nolva is used in PCT to help block the receptors from accepting estrogen during the estrogen rebound when coming off cycle.

Clomid is another serm that blocks estrogen from binding to the hypothalamus. It inhibits the negative feedback loop of estrogen on gonadotropin release and By doing so it up regulates the HPTA.

 

[Kmaster15]

AIs not only prevent sides but they prevent the free testosterone in your system from being converted and wasted into estrogen. SERMs are receptor blockers but DO NOTHING to "keep estrogen low during natural testosterone recovery (PCT)".

For more detail: AIs are taken to stop the enzyme from creating estrogen or to stop the action of estrogen on the receptor (note this is not the same as blocking the receptor like nolva does). They help treat sides such as high BP, high estrogen, water weight/bloat, oily skin, etc. to be used on cycle leading up to post cycle therapy (pct).

SERMS:
Nolva is a mixed receptor agonist/antagonist. It is an antagonist in breast tissue where it blocks the estrogen receptor from binding with the aromatase enzyme. In other tissues its an agonist blocker meaning it does react biologically with the tissue. Nolva is used in PCT to help block the receptors from accepting estrogen during the estrogen rebound when coming off cycle.

Clomid is another serm that blocks estrogen from binding to the hypothalamus. It inhibits the negative feedback loop of estrogen on gonadotropin release and By doing so it up regulates the HPTA.

Thank you for the great detail, really appreciate it. I know that some use letro as their Aromatase inhibitor (AI) during cycle and nolva + clomid for PTC. Why both nolva + clomid? (from what u wrote im guessing because they do slightly different things) what is most common or better choice as AI?
Also i agree that extending the cycle to 12 weeks is a better choice, from what ive read people make alot of their gains in the last 4 weeks. Will definitely do that.

 

[Docd187]

Thank you for the great detail, really appreciate it. I know that some use letro as their Aromatase inhibitor (AI) during cycle and nolva + clomid for PTC. Why both nolva + clomid? (from what u wrote im guessing because they do slightly different things) what is most common or better choice as AI?
Also i agree that extending the cycle to 12 weeks is a better choice, from what ive read people make alot of their gains in the last 4 weeks. Will definitely do that.

Your welcome! Letro is a very potent Aromatase inhibitor (AI) and can also be used to treat gyno after it has formed. It can completely crash your estrogen levels (any Aromatase inhibitor (AI) can do this but especially with letro) and should be started off very mildly and adjusted from there (again same with any Aromatase inhibitor (AI) but especially letro). Arimidex and letro are non suicidal AIs meaning once theyre metabolized out of your body by the liver they will cease to inhibit the synthesis of estrogen via reversible competition for the aromatase enzyme. Exemstane (aromasin) is ansuicidal Aromatase inhibitor (AI) meaning it forms a permanent deactivating bond with the aromatase enzyme. This is why there is no estrogen rebound coming off aromasin but there is with arimidex and letro. Arimidex and letro are non-steroidal AIs so they don't effect test levels or aid in HPTA shutdown like aromasin can since aromasin is steroidal. The half life of adex is around 2-3days I believe and around 2 days in letro so EOD dosing will suffice unless you're prone to aromatizarion in which Case your adjust dosing frequency or dosing volume. Exemstane has a shorter half life (some evidence points to it being less than a day in men) so an ED dose would be a good place to start. The trade off with aromasin is more of the drug is required to have an effect (minimum of 5mg but usually recommended at 6.25-12.5mg for aromasin and .25mg for adex and letro).

You're correct clomid AND nolva should both be used for PCT because they do different things through different pathways. Nolva only blocks estrogen receptors from binding with estrogen and does this very well in breast tissue which is why it's effective in PREVENTING (not curing) gyno. Coming off a steroidal cycle your estrogen levels will rebound but nolva will help stop gyno from forming and also estrogen from binding to other receptors in the body.

Clomid works in the hypothalamus by blocking the hypothalamus from bonding with estrogen. With exogenously high test levels your HPTA (natural test production) will shutdown and cease to produce. Clomid works through a negative feedback loop by inhibiting the binding here and restarting your natural production. Therefore a wise PCT choice would include both clomid and nolva.

It's not so much that many gains come in the final 4wks (gains can plateu towards the end of a cycle) as the reason to extend it to a minimum of 12 wks. It's more to do with testosterone ENANTHATE is a medium length ester. It will take around 4-6wks to fully "kick in". If you run a 10wk cycle that could potentially leave you with only 4wks of "on time".


*edit could probably have worded that better and fixed some typos but my fingers are beginning to cramp lol. Hope this gives some insight

 

[SpartacusOmega]

Good info regarding AI's n SERM's, keep us posted.