JC3, everyone here in chemical study know that 0,1um pore size filter all bacteria but let pass almost all virus spectrum and just not to mention endotoxins that require molecular range filters, and we only have macro-molecular ones!
But it also leads to other problems, it starts to be a hard has hell to filter by hand and really pushes your pacience for the time it takes! So it becames very unpratical specially on medium volumes..
You may see around here, that almost every veteran guy in brew use 0.45 and almost 0 infections!
So does it worth thinking about it? I think no, just take some extra care on handling!