Yeah...when I was diagnosed with interstitial nephritis, it was wicked. I'd wake up every morning wanting to puke with pain in my lower back / kidney area. My GFR rate was 59, and the doc said it was borderline stage 3 kidney disease. So I stopped the HRT injections and all other meds. Found out it was a sulfa allergy though that caused it, some antibiotics just don't agree with me lol. When my kidneys weren't functioning well, I couldn't even take fish oil due to the wanting to puke feeling. Canephron helped a lot though, it took the nausea away and now my GFR is between 83 - 91 due to time healing the rest. So, I would advise...always get your GFR and creatinine tested when you get routine bloodwork if you run a lot of supplements and whatever else, it could save you some troubles down the road.