aidenmanofrisque
New member
I'm writing this post because I have had a hard time finding any concrete info on prami or any other prolactin inhibitors. I have done a decent amount of digging and hope to pass on this info to anyone who is looking for it.
The short of it- Prami and all other D2 agonists (bromocryptine, caber etc.) share similar effects.
1)significant reduction in prolactin levels
2)increase in growth hormone levels
They are cheap and effective, use them before bed if you want either of these effects.
Full info session
As Prami is often the cheapest and most readily available of the D2 agonists it will be my focus. I personally experience terrible sides from 19-nor compounds, especially deca, so I use a lot of prami.
The main effects of D2 agonists
Prami is able to inhibit the production of prolactin by binding itself to the lactotropes on your pituitary. As long as these receptors have dopamine(or a dopamine agonist) bound to them they will stop the production of prolactin. This is very important if you are using any 19-nor compound(tren, deca, npp) because they are recognized as progesterone and activate your prolactin production. If you are like me, not controlling your prolactin leads to serious gyno, moodiness, and generally acting like a crazy pregnant woman.
Prami increases your GH production, by inhibiting the release of somatostatin. I repeat, IT STOPS YOUR SOMATOSTATIN PRODUCTION. It does so by binding to the somatostatin secreting part of your hypothalamus. Somatostatin aka growth hormone inhibiting hormone, is released in response to a negative feedback loop triggered by growth hormone and its various related hormones. Using a D2 agonists such as prami allows you to explode your natural GH production by shutting off the negative feedback loop. So, taking this before bed would allow you to endlessly produce GH while in REM.
Side Effects to be aware of
Decreased alertness and pupil response to changes in light intensity
Drowsiness - can be barely noticeable or so strong you can't stay awake
Nausea - usually mild, can be stronger when beginning usage
Dosing
It has been found that as little as 0.1 mg of an oral dose of prami effects both prolactin and GH production. The best figures I've found show that with a 0.5mg dose prolactin levels decreased by about 60% and GH increased by an astonishing 500%.
So, start with a small dose such as 0.1mg and work your way up to 0.5(or higher) if necessary.
There is very little research on long term use of these drugs other than for treatment of pituitary tumors, none of which provide significant info for the effects discussed in this post, but have at least found that an increase in dosage was not required for their usage.
Personal Experience
I find anywhere from .125-.5 mgs before bed to work very well. Usually experience very vivid dreams and sweat a lot, almost as bad as tren, due to GH increase. Do not take this during the day unless you don't have anything to do, i once made that mistake and found myself trying to drive half asleep and being blinded by the sun, with sunglasses on. It supposedly increases sexual pleasure, i have experienced sexual dysfunction from it (in males a post orgasm dopamine release triggers whole response that makes you feel satisfied and go flaccid).
References
ncbi.nlm.nih.gov/pmc/articles/PMC2203276/
nature.com/clpt/journal/v51/n5/abs/clpt199260a.html
Any feedback or questions are appreciated.
The short of it- Prami and all other D2 agonists (bromocryptine, caber etc.) share similar effects.
1)significant reduction in prolactin levels
2)increase in growth hormone levels
They are cheap and effective, use them before bed if you want either of these effects.
Full info session
As Prami is often the cheapest and most readily available of the D2 agonists it will be my focus. I personally experience terrible sides from 19-nor compounds, especially deca, so I use a lot of prami.
The main effects of D2 agonists
Prami is able to inhibit the production of prolactin by binding itself to the lactotropes on your pituitary. As long as these receptors have dopamine(or a dopamine agonist) bound to them they will stop the production of prolactin. This is very important if you are using any 19-nor compound(tren, deca, npp) because they are recognized as progesterone and activate your prolactin production. If you are like me, not controlling your prolactin leads to serious gyno, moodiness, and generally acting like a crazy pregnant woman.
Prami increases your GH production, by inhibiting the release of somatostatin. I repeat, IT STOPS YOUR SOMATOSTATIN PRODUCTION. It does so by binding to the somatostatin secreting part of your hypothalamus. Somatostatin aka growth hormone inhibiting hormone, is released in response to a negative feedback loop triggered by growth hormone and its various related hormones. Using a D2 agonists such as prami allows you to explode your natural GH production by shutting off the negative feedback loop. So, taking this before bed would allow you to endlessly produce GH while in REM.
Side Effects to be aware of
Decreased alertness and pupil response to changes in light intensity
Drowsiness - can be barely noticeable or so strong you can't stay awake
Nausea - usually mild, can be stronger when beginning usage
Dosing
It has been found that as little as 0.1 mg of an oral dose of prami effects both prolactin and GH production. The best figures I've found show that with a 0.5mg dose prolactin levels decreased by about 60% and GH increased by an astonishing 500%.
So, start with a small dose such as 0.1mg and work your way up to 0.5(or higher) if necessary.
There is very little research on long term use of these drugs other than for treatment of pituitary tumors, none of which provide significant info for the effects discussed in this post, but have at least found that an increase in dosage was not required for their usage.
Personal Experience
I find anywhere from .125-.5 mgs before bed to work very well. Usually experience very vivid dreams and sweat a lot, almost as bad as tren, due to GH increase. Do not take this during the day unless you don't have anything to do, i once made that mistake and found myself trying to drive half asleep and being blinded by the sun, with sunglasses on. It supposedly increases sexual pleasure, i have experienced sexual dysfunction from it (in males a post orgasm dopamine release triggers whole response that makes you feel satisfied and go flaccid).
References
ncbi.nlm.nih.gov/pmc/articles/PMC2203276/
nature.com/clpt/journal/v51/n5/abs/clpt199260a.html
Any feedback or questions are appreciated.
