Question about Aromasin ?
- Thread starter bobryan
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JimiThing
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When i run over 1 g a week of test (which is rare) I need 25mg exemestane daily. I realize everyone is different but 10mg/day is a low dose for that much test.
I think its very important to properly manage estrogen on cycle. I think you should keep it in the clinically normal range even when on cycle.
THE-DET-OAK
IncreasedMyT @ ULV
the total E2 is not important when using higher doses of androgens, it is better to be relative to the testosterone.
Why? When estrogen is suppressed, this drives down SHBG, which is good in moderation. keeping your SHBG too low in comparison to your TT will produce insulin resistant affects in the body. Having a good amount of free T is a positive, but when it becomes too high there is not enough SHBG to carry the testosterone to its target tissues, not to mention it has recently been show that SHBG plays a role in the the effectiveness of testosterone to bind at target tissues.
http://joe.endocrinology-journals.org/content/175/1/113.full.pdf
http://www.medical.siemens.com/siemens/en_GLOBAL/gg_diag_FBAs/files/news_views/spring00/techreports/zb170-b.pdf
keeping supraphysiological ranges of TT and E2 in physiological range, especially for long periods, can have serious negative impacts on your health.
It is more about the ratio than the total. It is better to titrate down on testosterone, rather than throw a bunch of Aromatase inhibitor (AI) at it.
If your taking so much testosterone that your estrogen levels are giving side effects, would it be smarter to lower T dose, allowing for less conversion, yet keeping TT roughly the same since its not converting? or to keep injecting the same amount of testosterone, just so it can convert to estrogen, so you can inhibit that conversion with Aromatase inhibitor (AI) ?
JustMy2cents
Why? When estrogen is suppressed, this drives down SHBG, which is good in moderation. keeping your SHBG too low in comparison to your TT will produce insulin resistant affects in the body. Having a good amount of free T is a positive, but when it becomes too high there is not enough SHBG to carry the testosterone to its target tissues, not to mention it has recently been show that SHBG plays a role in the the effectiveness of testosterone to bind at target tissues.
http://joe.endocrinology-journals.org/content/175/1/113.full.pdf
http://www.medical.siemens.com/siemens/en_GLOBAL/gg_diag_FBAs/files/news_views/spring00/techreports/zb170-b.pdf
keeping supraphysiological ranges of TT and E2 in physiological range, especially for long periods, can have serious negative impacts on your health.
It is more about the ratio than the total. It is better to titrate down on testosterone, rather than throw a bunch of Aromatase inhibitor (AI) at it.
If your taking so much testosterone that your estrogen levels are giving side effects, would it be smarter to lower T dose, allowing for less conversion, yet keeping TT roughly the same since its not converting? or to keep injecting the same amount of testosterone, just so it can convert to estrogen, so you can inhibit that conversion with Aromatase inhibitor (AI) ?
JustMy2cents
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