So.... the use of Nolva & IGF LR3 during post cycle therapy (pct) is a big no-no?

[vincenzo]

So.... the use of Nolva & IGF LR3 during PCT is a big no-no?

Read that use of Nolva reduces IGF-1 in the body. Does anyone know if its a significant amount? So IGF-1 LR3 should only be used after a Nolva post cycle therapy (pct) and not during?

Any peptide vets here done otherwise? Thanks guys..

 

[MeatHead96]

This is the first i have heard of this. I've used the two together.

 

[vincenzo]

i saw this on another forum. It was a 2005 post though, hence was just wondering if there was any truth to it...


Weissberger AJ, Ho KK.

Garvan Institute of Medical Research, St. Vincent's Hospital, Sydney, NSW, Australia.

To determine whether testosterone modulates the somatotropic axis in adult males, we compared 24-h GH secretion (from 20-min sampling, using Cluster analysis) and insulin -like growth factor-I (IGF-I) levels of five hypogonadal men (aged 20-32 yr) with those of six normal men (aged 21-27 yr), and examined the effects of testosterone replacement (testosterone enanthate 250 mg im monthly). To elucidate whether the action of testosterone on the somatotropic axis is direct, or requires the aromatization of testosterone to estradiol, we also examined the effects of the nonsteroidal antiestrogen, tamoxifen (20 mg/day for 3 weeks), on 24-h GH secretion and IGF-I levels in the normal men and in four of the hypogonadal men during concurrent testosterone treatment. Compared to the normal men, the hypogonadal men had significantly reduced mean GH pulse amplitude (3.1 +/- 0.6 vs. 8.4 +/- 1.7 micrograms/L, P < 0.05), but not pulse frequency. Testosterone treatment resulted in a significant increase in 24-h mean serum GH (0.7 +/- 0.2 to 1.4 +/- 0.2 micrograms/L, P < 0.05), mean GH pulse amplitude (3.1 +/- 0.6 to 5.2 +/- 0.8 micrograms/L, P < 0.01) and serum IGF-I (0.9 +/- 0.1 to 1.1 +/- 0.1 U/mL, P < 0.05). In the normal men, tamoxifen significantly reduced 24-h mean serum GH (1.1 +/- 0.3 to 0.5 +/- 0.1 micrograms/L, P < 0.05), mean GH pulse amplitude (8.4 +/- 1.7 to 4.7 +/- 0.4 micrograms/L, P < 0.05), and serum IGF-I (1.0 +/- 0.1 to 0.7 +/- 0.1 U/mL, P < 0.001). In the hypogonadal men on testosterone replacement , tamoxifen lowered 24-h mean serum GH (1.3 +/- 0.2 to 0.6 +/- 0.2 micrograms/L, P < 0.01), mean GH pulse amplitude (5.5 +/- 1.0 to 2.4 +/- 0.8 micrograms/L, P < 0.01), and serum IGF-I (1.2 +/- 0.1 to 0.8 +/- 0.1 U/mL, P < 0.05). We conclude that testosterone plays an important role in the modulation of the male somatotropic axis in adulthood, as appears to be the case in puberty, and that this effect is partly dependent on the aromatization of testosterone to estradiol.

 

[Mikebacker]

Interesting, first time I have ever heard this. I will say that since I began adding IGF to my post cycle therapy (pct) I seem to recover a lot faster. From what I gather from the article it would be smart to run IGF during your post cycle therapy (pct) alongside the Nolvadex, this will help combat the decreased IGF levels that the nolva causes

 

[juced_porkchop]

yes this is well known.. but tamox is used only for a few weeks on post cycle therapy (pct) so its not a big worry in my op, also why i rec clomid (and now Torem) over tamox or the combo of both.
I also do think peps help post cycle therapy (pct), peps like ghrp or igf1.

I would highly rec a small igf1 run in post cycle therapy (pct) even if your not that into peptides.
Personally i LOVE peptides.

 

[juced_porkchop]

Read that use of Nolva reduces IGF-1 in the body. Does anyone know if its a significant amount? So IGF-1 LR3 should only be used after a Nolva post cycle therapy (pct) and not during?

Any peptide vets here done otherwise? Thanks guys..

if you think nolva/tamox lowers igf1 levels why would you take it AFTER? you would take it during.
igf1 doesnt stimulate igf1 your ADDING igf1.

run it WITH not after.

 

[vincenzo]

Thanks for the reply guys.

Yeah, I've decided to run IGF LR3 during post cycle therapy (pct). 50mcg subq, daily for about 20days. Im gonna do it all pre-workout as that just suits my schedule more. Will definitely try pinning post next cycle, just to see the difference.

Any advice on pinning timing on non-training days?

 

[MeatHead96]

Thanks for the reply guys.

Yeah, I've decided to run IGF LR3 during post cycle therapy (pct). 50mcg subq, daily for about 20days. Im gonna do it all pre-workout as that just suits my schedule more. Will definitely try pinning post next cycle, just to see the difference.

Any advice on pinning timing on non-training days?

First thing in the morning is good on off days.

 

[scientific nick]

I don't know the mechanism of action through which IGF1 is inhibited by nolva, but if it's in production, rather than binding sites, IGF is a MUST. If the mechanism is by an inhibitory substrate, then it would seemingly be atleast somewhat wasteful. No one has had any problems, so I bet it's modification in production.