cjw2021
Pro Bodybuilder
So your estrogen is under 30, your free testosterone is high normal, your SHBG is under 25, and you still feel like shit? Having experienced this problem I believe I have figured out the solution.
Three models I am using to solve chronic fatigue syndrome are
1) Many people are unable to convert B vitamins to their active forms. (20% of people cannot convert folic acid to its active form). This people are referred to as having "undermethylation".
2) The DHEA (AM) and Melatonin (PM) diurnal rhythm is disrupted/deficient.
3) Downregulation of Liver Enzymes That convert Cholesterol to Pregnenolone while on HRT. (Pregnenolone is the mother hormone and a neurosteroid).
In my case #1 was contributing to #2. Number three is just icing on the cake. Number 3 is solved by adding HCG which stimulates those enzymes and you can add 10mg twice daily of sublingual pregnenolone. This will stave off hair loss since progesterone (a metabolite of pregnenolone) will locally downregulate DHT in the hair follicles and possibly in the prostate. A lot of it will downregulate DHT everywhere. I also take one pill of ox bile and gnc's multi enzyme formula in the blue bottle once before meals. I have noticed a huge increase in nutrient absorption and muscle mass from doing this alone.
Since my body was not metabolizing b vitamins properly, serotonin and other neurotransmitters were not synthesizing properly. A single b vitamin not converting due to a genetic enzyme deficiency in "undermethylaters" can cause a breakdown of up to 600 body processes. Ultimately fatigue corresponds to a lack of biological energy. Seeing as my hormones were in check, there was no reason for this much fatigue. The lack of serotonin was causing inadequate melatonin synthesis and immune deficiencies as well as a prostaglandin e2 excess which entirely suppresses the immune system and inflames the entire body.
So in conclusion, I switched to a liquid multi vitamin, added dhea spray (2 sprays twice a day at wakeup and say 3PM), and added dibencozide and methylcobalamin (2 active forms of b12), p5p (active form of b6), Metafolin (folic acid active form), and as cofactors zinc, chromium gtf, sustained release niacin, and sAME. I got a COENZYME B complex that contains other coenzyme versions of the b vitamins which I take daily.
Symptoms of undermethylation are fatigue and nervous hyperexcitability probably with a tendency to insomnia.
What I found was that if someone is deficient in these cofactors due to inability to convert these b vitamins, or if someone is just deficient in niacin, tryptophan will convert into niacin and quinolenic acid (this acid is highly neurotoxic and implicated in many diseases of the nervous system). slow release niacin (not the non flush hex kind which is biologically inactive also effectively inhibits adrenaline if taken 2-3 times a day. So essentially serotonin was deficient because tryptophan was converting to a toxic byproduct and niacin due to inefficiencies in converting the b vitamins (undermethylation). These methyl groups of these conenzyme forms of these b vitamins contribute to energy in the body, and without them everything breaks down.
These are what I have discovered are the probably most common mechanisms of chronic fatigue syndrome. I know this was long but I hope this post can help someone if your labs are high normal and you still feel like shit. IMO this formula should cure 90% of chronic fatigue sufferers granted their hormone levels are in check.
As a side note, I much prefer tryptophan to 5-htp or even an SSRI because tryptophan has a rate limited step in its conversion to serotonin. 5-htp and SSRIs do not. Excessive serotonin has been linked to multiple problems. A good test to see if you are metabolizing tryptophan properly to serotonin is just to pop 500mg and see if you become flushed and hyper (from niacin conversion and toxins) or mildly sedated.
Three models I am using to solve chronic fatigue syndrome are
1) Many people are unable to convert B vitamins to their active forms. (20% of people cannot convert folic acid to its active form). This people are referred to as having "undermethylation".
2) The DHEA (AM) and Melatonin (PM) diurnal rhythm is disrupted/deficient.
3) Downregulation of Liver Enzymes That convert Cholesterol to Pregnenolone while on HRT. (Pregnenolone is the mother hormone and a neurosteroid).
In my case #1 was contributing to #2. Number three is just icing on the cake. Number 3 is solved by adding HCG which stimulates those enzymes and you can add 10mg twice daily of sublingual pregnenolone. This will stave off hair loss since progesterone (a metabolite of pregnenolone) will locally downregulate DHT in the hair follicles and possibly in the prostate. A lot of it will downregulate DHT everywhere. I also take one pill of ox bile and gnc's multi enzyme formula in the blue bottle once before meals. I have noticed a huge increase in nutrient absorption and muscle mass from doing this alone.
Since my body was not metabolizing b vitamins properly, serotonin and other neurotransmitters were not synthesizing properly. A single b vitamin not converting due to a genetic enzyme deficiency in "undermethylaters" can cause a breakdown of up to 600 body processes. Ultimately fatigue corresponds to a lack of biological energy. Seeing as my hormones were in check, there was no reason for this much fatigue. The lack of serotonin was causing inadequate melatonin synthesis and immune deficiencies as well as a prostaglandin e2 excess which entirely suppresses the immune system and inflames the entire body.
So in conclusion, I switched to a liquid multi vitamin, added dhea spray (2 sprays twice a day at wakeup and say 3PM), and added dibencozide and methylcobalamin (2 active forms of b12), p5p (active form of b6), Metafolin (folic acid active form), and as cofactors zinc, chromium gtf, sustained release niacin, and sAME. I got a COENZYME B complex that contains other coenzyme versions of the b vitamins which I take daily.
Symptoms of undermethylation are fatigue and nervous hyperexcitability probably with a tendency to insomnia.
What I found was that if someone is deficient in these cofactors due to inability to convert these b vitamins, or if someone is just deficient in niacin, tryptophan will convert into niacin and quinolenic acid (this acid is highly neurotoxic and implicated in many diseases of the nervous system). slow release niacin (not the non flush hex kind which is biologically inactive also effectively inhibits adrenaline if taken 2-3 times a day. So essentially serotonin was deficient because tryptophan was converting to a toxic byproduct and niacin due to inefficiencies in converting the b vitamins (undermethylation). These methyl groups of these conenzyme forms of these b vitamins contribute to energy in the body, and without them everything breaks down.
These are what I have discovered are the probably most common mechanisms of chronic fatigue syndrome. I know this was long but I hope this post can help someone if your labs are high normal and you still feel like shit. IMO this formula should cure 90% of chronic fatigue sufferers granted their hormone levels are in check.
As a side note, I much prefer tryptophan to 5-htp or even an SSRI because tryptophan has a rate limited step in its conversion to serotonin. 5-htp and SSRIs do not. Excessive serotonin has been linked to multiple problems. A good test to see if you are metabolizing tryptophan properly to serotonin is just to pop 500mg and see if you become flushed and hyper (from niacin conversion and toxins) or mildly sedated.
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