This might be moved to the supplement section, but i figured it woud get more views here, its intresting to say the least. Long too.
What I'm about to reveal has been a closely held secret for more than a year. Since it's potentially the greatest functional improvement ever to hit the fat-loss market, we needed to keep things hush-hush to prevent pirate companies from stealing the idea. It's too late for anyone to interfere with us now; patents have been filed and we've just finished manufacturing the first batch of our formulation.
The reason for all this protection? Bottom line, we've made ephedra and the current crop of fat-loss supplements obsolete!
This is definitely not an overstatement and our competitors know it.
What makes our invention so valuable and unique? First of all, it's far more effective at burning off body fat than anything that's ever been on the market. Furthermore, unlike ephedra-based formulas, it doesn't down-regulate beta-receptor sites and become ineffective over time.
And get this… It also increases protein synthesis and the natural production of anabolic substrates (in both men and women). In other words, it may actually help to preserve or even build muscle mass.
Even better yet, all of these metabolic benefits are sustained, around the clock, week after week, as long as you continue to take the formula.
We honestly believe that we've developed the fat-loss phenomenon that everyone's been hoping for. Ever since the ripped look's been the passionate desire of every body-conscious individual, there's been a quest for a fat burner that, in addition to continuously melting off adipose tissue, would help to preserve — even promote — muscle-mass gains.
And we've done it! Not only that, it's far more effective than any of us involved with the project ever dreamed possible. What you're about to learn is truly revolutionary. And there's no doubt in our minds that, after reading what follows, you'll be a believer, too.
The name of our fat-loss phenomenon is HOT-ROX, but before I get into the science behind its formula, I want to blow the lid off ephedra and show it for what it really is — a so-so fat-loss agent. Next, I'm going to lay out the process in which your body actually reduces its fat stores. It may actually surprise you. Then I'll explain the science behind HOT-ROX.
What's the Big Deal with Ephedra, Anyway?
Why is everyone so focused on adrenergic compounds, like ephedra? A better thermogenic mousetrap should've replaced them years ago. Unfortunately, instead of being innovative, supplement companies became complacent, relying heavily upon the jitter-buzz factor (not the popular dance of the 1920s, but the feeling you get from ephedra) to sell their products.
Think about it… If ephedra-based products were all that effective, why are you reading this article? How many bottles of fat-loss supplements have you purchased in the last five years, anyway? If you're like most of us, you've spent a small fortune and you're still not as lean as you want to be. Oh, we like to pretend that being lean isn't that important to us, but who are we kidding? It is that important. And it's depressing to see the same fat pads taunting us in the mirror each day.
We all struggle with it, too. No matter what's utilized, it's very difficult to achieve and maintain the degree of leanness you're after.
But now, fat-loss supplements as a whole have changed for the worse. Ephedra has been effectively squeezed out of the market due to pressure from the federal government and insurance carriers. Supplement companies don't know what to do about it, either. Most are opting out of the market or worse yet, making very weak, watered-down versions of their popular brands and calling them ephedra free! Like that's something good — yeah, the same way alcohol-free beer is good.
Even though ephedra isn't the best solution for fat loss, it's a heck of a lot better than the green tea, synephrine, or octopamine concoctions you see popping up all over the place. Still, the point's being missed:
I don't know why this isn't obvious to everyone, but adrenergic compounds, in and of themselves, aren't all that powerful. In fact, ephedrine, in the absence of caffeine, is barely even worth considering as a fat-loss agent. Furthermore, if you attempt to keep ephedrine levels continuously elevated (24/7), which is what's required for optimal fat loss, beta receptors down-regulate, making ephedra even less effective.
Yes, adrenergic compounds do increase lipolysis, but the magnitude is limited due to the fact that there's a finite number of beta receptors, which tend to down-regulate over time. So there's an ever-lowering ceiling that you can't exceed when stimulating lipolysis through the beta receptor.
Rapid Fat Loss — A Mission of 2 Tasks
Whenever someone discusses fat loss, the science is often oversimplified and misleading. And when asked to explain the whys behind the metabolic processes that led to successful fat loss, most experts I speak with stutter and stammer. It just shouldn't be this way. You really need to understand the entire process in order to achieve and sustain any degree of leanness. Otherwise, your results will be an unpredictable hit and miss.
The first thing to understand is that almost everyone has it backward. They hope that by burning energy, say on a Stairmaster, this will somehow suck the fat right out of their blurred abs or other problem areas. This simply isn't true. There is no pipeline through which muscle can pull fat from adipocytes. There must be ample supplies of fatty acids in the bloodstream to use as fuel or the muscle burns itself!
People also hope that cutting calories will guarantee fat loss. This also isn’t true. Again, energy-burning won’t suck fat from the fat cells. The energy can and often will come from glycogen or muscle protein. And most important, caloric reduction slows the metabolism and can actually interfere with fat release!
Once this occurs, you're in a physiological nightmare… A state that not only makes it nearly impossible to lose any additional body fat, but you also begin to lose muscle mass as well, leaving you skinny-fat.
Triggering lipolysis is the crucial first step, but you must also support the burn. If not, it's perfectly plausible to stimulate lipolysis only to have the fat redistributed back into adipocytes. What a waste of time!
You need to see the complete picture, and in simple terms, it all begins with lipolysis and ends with fatty-acid oxidation. Understanding the intermediary steps, however, will put you miles ahead of the game. It's also a requirement if you're going to design or, as a consumer, evaluate an effective fat-loss supplement.
If your goal is to get as lean as possible while maintaining or even gaining muscle mass, in addition to managing caloric intake, you must successfully accomplish two and only two critical tasks. Everything else is subordinate to these:
1) Support rapid lipolysis (fat release) while simultaneously minimizing lipogenesis (fat creation).
2) Keep the TCA* cycle primed for maximum, aerobic-metabolic burn.
*Note: The TCA (tricarboxylic acid) cycle is also known as the Krebs cycle or aerobic metabolism.
If successful in accomplishing both tasks, the body will remain in a positive lipolytic balance, and at the same time, metabolic rate will be maximized, producing a thermogenic tsunami that cascades throughout the body. Control these two areas and you should be able to achieve just about any degree of leanness you desire. It's just a matter of knowing how.
But before we get to the how, it's important to elaborate on these two tasks and get a better understanding of what's actually occurring inside these bodies of ours. I'm going to attempt to keep this thorough yet simple. It's important to understand the science because it's the basis for the HOT-ROX design.
TASK 1 — Release the Fat Hounds!
Lipolysis Up, Lipogenesis Down
Simply put, the goal here is to get the fat cells to release fat (lipolysis) faster than they create fat from dietary calories (lipogenesis).
If you want to induce lipolysis, you have to increase cAMP (cyclic adenosine monophosphate). Cyclic AMP is responsible for triggering the cellular processes for lipid metabolism. In other words, it's the chief gatekeeper for stimulating lipolysis and slowing lipogenesis.
Ramping up cAMP within fat cells activates protein kinase, which in turn activates hormone-sensitive lipase, the enzyme that breaks down the fat in adipocytes, releasing free fatty acids and glycerol into the bloodstream. Good sensitivity to hormone-sensitive lipase depends upon ample thyroid hormone being present. If T3 levels are low, lipase activity won't increase as it should. In contrast, increased cAMP in combination with high T3 levels will send lipolysis rates through the roof.
Cyclic AMP can be stimulated directly by increasing adenylate-cyclase activity. Adrenergic compounds (endogenous or exogenous) can also indirectly increase cAMP by activating adenylate cyclase when binding beta receptors. The adrenoreceptor route, as mentioned before, has its limitations.
Additionally, both increased cAMP and high T3 levels decrease lipoprotein lipase activity, which is an enzyme responsible for lipogenesis. So in addition to stimulating lipolysis, cAMP and T3, as a team, put the kibosh on lipogenesis as well.
This double-whammy effect that cAMP and T3 deliver is very powerful, priming the body for the burn.
TASK 2 — Prime the TCA Cycle
Ignition and Burn
When lipolysis outraces lipogenesis and releases fatty acids into the blood, these diffuse into all cells of the body to be used as fuel.
Upon entering a cell, fatty acids are actively transported, via carnitine acyltransferase, into mitochondria, which act as cellular power plants. Once in the mitochondria, the fatty acid is converted into fatty acid-CoA. Next, the fatty acid-CoA is broken down further, two carbons at a time, into acetyl-CoA. And acetyl-CoA is the "fat" that fuels aerobic metabolism through the TCA (tricarboxylic acid) cycle. In other words, when you think of burning off body fat, the actual "fat" being consumed is actually acetyl-CoA.
This is when T3 plays another huge role. T3 produces thermogenic malic enzyme, which is the intermediary required to produce oxaloacetate. And oxaloacetate, in combination with acetyl-CoA, fuels the TCA cycle. For maximum thermogenesis, via the TCA cycle, oxaloacetate needs to be present in ample amounts or the entire process falls apart — once oxaloacetate levels drop, the TCA cycle slows proportionally.
This is a weak link in the TCA cycle and requires exogenous support through nutritional means if you want to maintain continuous and rapid fat loss. In other words, if you want to be in control of thermogenesis and not subject to intermittent and hit-and-miss responses, then you need to make sure oxaloacetate levels are high. And you do that through nutritional means, which I'll go over later.
Additionally, T3 increases UCP3 uncoupling protein, which can have profound effects on fat loss. In fat cells, uncoupling dramatically increases lipolysis. And in other tissues, like in muscle, uncoupling increases metabolic rate, thus supporting the burn. The net effect is faster fat release from adipocytes, followed by faster fat burning due to an overall-increased metabolic rate.
The Whole Fat-Loss Enchilada
Bottom line, if you ramp up and sustain high cAMP and T3 levels, you've done all that's required for maximum, continual fat metabolism. In essence, you've achieved what's tantamount to thermogenic nuclear war.
(Managing food intake is, of course, also required; hopefully that's obvious.)
So how do we formulate a supplement that sustains non-beta-receptor-mediated cAMP and increased T3 levels without causing down-regulation?
Well, we have the answer. Specifically, we've developed a series of compounds that when combined, produces a more profound effect than our greatest expectations. In fact, at this point, we can't imagine anything better.
The horsepower that fuels HOT-ROX is comprised of two novel compounds and their synergists. The big daddy, which is also the real magic behind our formula, is called A7-E™. A7-E was designed from scratch by Bill Roberts and is best described as a tricked out, supercharged version of 7-keto DHEA.
A7-E is completely new to the industry; it has a patent filed on it; and it's so powerful on its own as a fat-loss agent that there's no contest when compared to anything else that's currently on the market. A7-E launches us right smack dab in the middle of a new fat-loss era!
A7-E™ — Rev Up and Potentiate Thyroid Activities
The most challenging task was finding a way to boost T3 levels without suppressing TSH. From the scientific literature, there are two compounds that when taken together in relatively high dosages, would do the trick nicely: 7-keto DHEA supported by guggulsterones.
7-Keto DHEA has been shown to increase T3 in humans by as much as 30% (200 mg/day) without suppressing TSH! Additionally, and to a much greater degree, 7-keto DHEA increases thermogenic malic enzyme. Remember, malic enzyme is the compound responsible for producing oxaloacetate, which fuels the TCA cycle.
Guggulsterones, on the other hand, increase the peripheral
What I'm about to reveal has been a closely held secret for more than a year. Since it's potentially the greatest functional improvement ever to hit the fat-loss market, we needed to keep things hush-hush to prevent pirate companies from stealing the idea. It's too late for anyone to interfere with us now; patents have been filed and we've just finished manufacturing the first batch of our formulation.
The reason for all this protection? Bottom line, we've made ephedra and the current crop of fat-loss supplements obsolete!
This is definitely not an overstatement and our competitors know it.
What makes our invention so valuable and unique? First of all, it's far more effective at burning off body fat than anything that's ever been on the market. Furthermore, unlike ephedra-based formulas, it doesn't down-regulate beta-receptor sites and become ineffective over time.
And get this… It also increases protein synthesis and the natural production of anabolic substrates (in both men and women). In other words, it may actually help to preserve or even build muscle mass.
Even better yet, all of these metabolic benefits are sustained, around the clock, week after week, as long as you continue to take the formula.
We honestly believe that we've developed the fat-loss phenomenon that everyone's been hoping for. Ever since the ripped look's been the passionate desire of every body-conscious individual, there's been a quest for a fat burner that, in addition to continuously melting off adipose tissue, would help to preserve — even promote — muscle-mass gains.
And we've done it! Not only that, it's far more effective than any of us involved with the project ever dreamed possible. What you're about to learn is truly revolutionary. And there's no doubt in our minds that, after reading what follows, you'll be a believer, too.
The name of our fat-loss phenomenon is HOT-ROX, but before I get into the science behind its formula, I want to blow the lid off ephedra and show it for what it really is — a so-so fat-loss agent. Next, I'm going to lay out the process in which your body actually reduces its fat stores. It may actually surprise you. Then I'll explain the science behind HOT-ROX.
What's the Big Deal with Ephedra, Anyway?
Why is everyone so focused on adrenergic compounds, like ephedra? A better thermogenic mousetrap should've replaced them years ago. Unfortunately, instead of being innovative, supplement companies became complacent, relying heavily upon the jitter-buzz factor (not the popular dance of the 1920s, but the feeling you get from ephedra) to sell their products.
Think about it… If ephedra-based products were all that effective, why are you reading this article? How many bottles of fat-loss supplements have you purchased in the last five years, anyway? If you're like most of us, you've spent a small fortune and you're still not as lean as you want to be. Oh, we like to pretend that being lean isn't that important to us, but who are we kidding? It is that important. And it's depressing to see the same fat pads taunting us in the mirror each day.
We all struggle with it, too. No matter what's utilized, it's very difficult to achieve and maintain the degree of leanness you're after.
But now, fat-loss supplements as a whole have changed for the worse. Ephedra has been effectively squeezed out of the market due to pressure from the federal government and insurance carriers. Supplement companies don't know what to do about it, either. Most are opting out of the market or worse yet, making very weak, watered-down versions of their popular brands and calling them ephedra free! Like that's something good — yeah, the same way alcohol-free beer is good.
Even though ephedra isn't the best solution for fat loss, it's a heck of a lot better than the green tea, synephrine, or octopamine concoctions you see popping up all over the place. Still, the point's being missed:
I don't know why this isn't obvious to everyone, but adrenergic compounds, in and of themselves, aren't all that powerful. In fact, ephedrine, in the absence of caffeine, is barely even worth considering as a fat-loss agent. Furthermore, if you attempt to keep ephedrine levels continuously elevated (24/7), which is what's required for optimal fat loss, beta receptors down-regulate, making ephedra even less effective.
Yes, adrenergic compounds do increase lipolysis, but the magnitude is limited due to the fact that there's a finite number of beta receptors, which tend to down-regulate over time. So there's an ever-lowering ceiling that you can't exceed when stimulating lipolysis through the beta receptor.
Rapid Fat Loss — A Mission of 2 Tasks
Whenever someone discusses fat loss, the science is often oversimplified and misleading. And when asked to explain the whys behind the metabolic processes that led to successful fat loss, most experts I speak with stutter and stammer. It just shouldn't be this way. You really need to understand the entire process in order to achieve and sustain any degree of leanness. Otherwise, your results will be an unpredictable hit and miss.
The first thing to understand is that almost everyone has it backward. They hope that by burning energy, say on a Stairmaster, this will somehow suck the fat right out of their blurred abs or other problem areas. This simply isn't true. There is no pipeline through which muscle can pull fat from adipocytes. There must be ample supplies of fatty acids in the bloodstream to use as fuel or the muscle burns itself!
People also hope that cutting calories will guarantee fat loss. This also isn’t true. Again, energy-burning won’t suck fat from the fat cells. The energy can and often will come from glycogen or muscle protein. And most important, caloric reduction slows the metabolism and can actually interfere with fat release!
Once this occurs, you're in a physiological nightmare… A state that not only makes it nearly impossible to lose any additional body fat, but you also begin to lose muscle mass as well, leaving you skinny-fat.
Triggering lipolysis is the crucial first step, but you must also support the burn. If not, it's perfectly plausible to stimulate lipolysis only to have the fat redistributed back into adipocytes. What a waste of time!
You need to see the complete picture, and in simple terms, it all begins with lipolysis and ends with fatty-acid oxidation. Understanding the intermediary steps, however, will put you miles ahead of the game. It's also a requirement if you're going to design or, as a consumer, evaluate an effective fat-loss supplement.
If your goal is to get as lean as possible while maintaining or even gaining muscle mass, in addition to managing caloric intake, you must successfully accomplish two and only two critical tasks. Everything else is subordinate to these:
1) Support rapid lipolysis (fat release) while simultaneously minimizing lipogenesis (fat creation).
2) Keep the TCA* cycle primed for maximum, aerobic-metabolic burn.
*Note: The TCA (tricarboxylic acid) cycle is also known as the Krebs cycle or aerobic metabolism.
If successful in accomplishing both tasks, the body will remain in a positive lipolytic balance, and at the same time, metabolic rate will be maximized, producing a thermogenic tsunami that cascades throughout the body. Control these two areas and you should be able to achieve just about any degree of leanness you desire. It's just a matter of knowing how.
But before we get to the how, it's important to elaborate on these two tasks and get a better understanding of what's actually occurring inside these bodies of ours. I'm going to attempt to keep this thorough yet simple. It's important to understand the science because it's the basis for the HOT-ROX design.
TASK 1 — Release the Fat Hounds!
Lipolysis Up, Lipogenesis Down
Simply put, the goal here is to get the fat cells to release fat (lipolysis) faster than they create fat from dietary calories (lipogenesis).
If you want to induce lipolysis, you have to increase cAMP (cyclic adenosine monophosphate). Cyclic AMP is responsible for triggering the cellular processes for lipid metabolism. In other words, it's the chief gatekeeper for stimulating lipolysis and slowing lipogenesis.
Ramping up cAMP within fat cells activates protein kinase, which in turn activates hormone-sensitive lipase, the enzyme that breaks down the fat in adipocytes, releasing free fatty acids and glycerol into the bloodstream. Good sensitivity to hormone-sensitive lipase depends upon ample thyroid hormone being present. If T3 levels are low, lipase activity won't increase as it should. In contrast, increased cAMP in combination with high T3 levels will send lipolysis rates through the roof.
Cyclic AMP can be stimulated directly by increasing adenylate-cyclase activity. Adrenergic compounds (endogenous or exogenous) can also indirectly increase cAMP by activating adenylate cyclase when binding beta receptors. The adrenoreceptor route, as mentioned before, has its limitations.
Additionally, both increased cAMP and high T3 levels decrease lipoprotein lipase activity, which is an enzyme responsible for lipogenesis. So in addition to stimulating lipolysis, cAMP and T3, as a team, put the kibosh on lipogenesis as well.
This double-whammy effect that cAMP and T3 deliver is very powerful, priming the body for the burn.
TASK 2 — Prime the TCA Cycle
Ignition and Burn
When lipolysis outraces lipogenesis and releases fatty acids into the blood, these diffuse into all cells of the body to be used as fuel.
Upon entering a cell, fatty acids are actively transported, via carnitine acyltransferase, into mitochondria, which act as cellular power plants. Once in the mitochondria, the fatty acid is converted into fatty acid-CoA. Next, the fatty acid-CoA is broken down further, two carbons at a time, into acetyl-CoA. And acetyl-CoA is the "fat" that fuels aerobic metabolism through the TCA (tricarboxylic acid) cycle. In other words, when you think of burning off body fat, the actual "fat" being consumed is actually acetyl-CoA.
This is when T3 plays another huge role. T3 produces thermogenic malic enzyme, which is the intermediary required to produce oxaloacetate. And oxaloacetate, in combination with acetyl-CoA, fuels the TCA cycle. For maximum thermogenesis, via the TCA cycle, oxaloacetate needs to be present in ample amounts or the entire process falls apart — once oxaloacetate levels drop, the TCA cycle slows proportionally.
This is a weak link in the TCA cycle and requires exogenous support through nutritional means if you want to maintain continuous and rapid fat loss. In other words, if you want to be in control of thermogenesis and not subject to intermittent and hit-and-miss responses, then you need to make sure oxaloacetate levels are high. And you do that through nutritional means, which I'll go over later.
Additionally, T3 increases UCP3 uncoupling protein, which can have profound effects on fat loss. In fat cells, uncoupling dramatically increases lipolysis. And in other tissues, like in muscle, uncoupling increases metabolic rate, thus supporting the burn. The net effect is faster fat release from adipocytes, followed by faster fat burning due to an overall-increased metabolic rate.
The Whole Fat-Loss Enchilada
Bottom line, if you ramp up and sustain high cAMP and T3 levels, you've done all that's required for maximum, continual fat metabolism. In essence, you've achieved what's tantamount to thermogenic nuclear war.
(Managing food intake is, of course, also required; hopefully that's obvious.)
So how do we formulate a supplement that sustains non-beta-receptor-mediated cAMP and increased T3 levels without causing down-regulation?
Well, we have the answer. Specifically, we've developed a series of compounds that when combined, produces a more profound effect than our greatest expectations. In fact, at this point, we can't imagine anything better.
The horsepower that fuels HOT-ROX is comprised of two novel compounds and their synergists. The big daddy, which is also the real magic behind our formula, is called A7-E™. A7-E was designed from scratch by Bill Roberts and is best described as a tricked out, supercharged version of 7-keto DHEA.
A7-E is completely new to the industry; it has a patent filed on it; and it's so powerful on its own as a fat-loss agent that there's no contest when compared to anything else that's currently on the market. A7-E launches us right smack dab in the middle of a new fat-loss era!
A7-E™ — Rev Up and Potentiate Thyroid Activities
The most challenging task was finding a way to boost T3 levels without suppressing TSH. From the scientific literature, there are two compounds that when taken together in relatively high dosages, would do the trick nicely: 7-keto DHEA supported by guggulsterones.
7-Keto DHEA has been shown to increase T3 in humans by as much as 30% (200 mg/day) without suppressing TSH! Additionally, and to a much greater degree, 7-keto DHEA increases thermogenic malic enzyme. Remember, malic enzyme is the compound responsible for producing oxaloacetate, which fuels the TCA cycle.
Guggulsterones, on the other hand, increase the peripheral