23 yo, symptoms and blood work.

Kwerk

New member
Hello, first off, you may see this post in other forums around the internet. I'm desperate.

I've been training seriously for about 4 years, with my peak in terms of strength and physique having been about 2 year ago. Since then everything's gone downhill. I'm a 23 year old 5 foot 8 man weighing a consistent 190 lbs, with prominent love handles, belly fat, and lower back fat. My waist 2 years ago was a 34, now it's at 36 and getting uncomfortably close to 38.

I was diagnosed with Crohn's disease at 6 years old and have been on and off long courses of Prednisone through youth and puberty. I have also been obese, the fat kind, all that time until about age 18 when I had a surgery to remove the affected area of small intestine and swore to never neglect my health again. Since then, diet and training have been on point. Well, until all this started and I couldn't train without the injuries I thought had gone away coming back just as bad as when they began. I currently take immuno-suppressant drugs to hopefully keep the Crohn's in remission.

During puberty I grew a few inches taller and developed minuscule muscle mass, but did get some gyno.

The only Iodine I ever got as a child must have been by accident, because my parents were those people who think they know about health but know nothing.
I started supplementing last October.

In the last year and a half I've experienced lack of libido, joint and muscle pains, strains, and sprains that don't go away, fat accumulation, strength loss, extreme fatigue, difficulty concentrating, and severe irritability.

My GP heard me out and took some basic tests, then referred me to an Endo.

Original GP tests from January:

Total Test: 742 240-950
Free Test: 20 9-30
Vit D: 51 32-100
TSH: 2.619 0.340 - 5.600

More tests from Endo in February

TSH: 2.7 0.4-4.5
Total Test: 724 250-1100
Free Test: 78.6 46-224
Bioavailable Test: 168.4 110-575
SHBG: 45 10-50
Albumin: 4.7 3.6-5.1
Prolactin: 6.0 2-18
T3 Total 82 76-181
FSH: 2.6 1.6-8.0
LH: 4.1 1.5-9.3
E2: 43 <=39
ACTH: 25 6-50
Cortisol AM: 17.5 mcg/dL No Range
Free T4: 1.2 0.8-1.8
IGF-1: 203 83-456
Z Score: 0 -2.0 +2.0
Thyroglobulin Antibodies: 24 <20 IU/mL
Thyroid Peroxidase Antibodies <10 <35 IU/mL

My endo is slightly concerned about the E2 and Thyroglobulin Antibodies, but I am VERY concerned. When I found out my TT was over 700, my first though was "Wow, someone tell that to my body." Her opinion on every single level was either "well, it's in the normal range," or "well, it's outside the normal range but not all people function optimally within these ranges so I'm not too worried."

DUDE, IF I WAS FUNCTIONING OPTIMALLY, I WOULD NOT BE IN YOUR OFFICE WITH LISTS OF SYMPTOMS AND BEGGING FOR HELP.

At this point, I'll take all the advice and guidance I can get, so please hit me with it. Ask any questions I may have not addressed here, suggest anything.

Thanks, all!
 
Looks like you had the regular estradiol assay performed. Get the sensitive assay which is more accurate at the lower levels found in men.

I don't see any issues with your numbers. Have you had a sleep study done?
 
Your T levels are really good but you're aromatizing a decent amount of E2. Was that lab a sensitive E2 test? The best advice I would have to offer based on what you wrote here is to get on a strict(er) diet and ramp up some cardio...lose some of the fat and then retest E2. I think the easy answer would be to throw a little bit of AI at it to control E2 but I would bet that if you lost some of the fat, which I dont think would be too hard with your T levels being what they are, your E2 would likely drop.
 
No sleep study, but if I was a restless sleeper or heavy snorer someone would have told me between girlfriends, college roommates, and parents.

Believe me I'm trying to lose the fat and get stronger. I do the squats, dead lifts, bench, overhead, the rowing intervals, the carb timing, it just leaves me looking the same every day and with more painful hips and back.
 
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Diet is good. I do the intermittent fasting, no wheat, lots of eggs and animal fats, real butter and full fat milk and cream, broccoli and other greens, beef roasts and chicken breasts, fruit and other junk only after or before workouts. Cholesterol is perfect, too. Fish oil, D, zinc, iodine, and a multi every day.

Do I just tell the doctor I want the study? And to bill my insurance and it will be okay?
 
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Got a call about the second set of labs. E2 came back at 49. Calcium a little bit high. Doctor ordered some adrenal tests with DHEA-S to determine if I need a CAT scan. Will have them drawn tomorrow.

I asked about prescriptions to lower the E2, but she's very noncommittal and thinks my functional normal e2 level just happens to be double the healthy level. Anyone on this board a Chicago suburbs endocrinologist willing to look at me?

Anyway, should these next labs prove I don't have an adrenal tumor then I'll be having the "let's try an AI or I'll find a doctor willing to address my out of range E2 and high-normal SHBG and low FT" conversation.
 
Is that the regular or sensitive E2. If regular your probably fine. If you don't know which it was, post the reference range and we can usually tell by that.
 
The reference range was <39.

That looks like the regular assay. It is inaccurate at the lower levels found in men and generally overstates how high your E2 is. Your E2 is most likely perfectly fine. I highly doubt that you need to take anything for it.
 
I just got one more result back, DHEA-S is at 155 on a range from 110-510 mcg/dL. Does anyone know what a good DHEA-S is for a young man?

and Pregnenolone is at 127 on a range of <905 ng/dL
 
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