Low dose of 10-20mg a day and then maintenance with 20mg twice a week did wonders for my acne when nothing else worked for me. It def is a last resort thing but I literally had almost no sides at this dose and liver enzymes were always just barely elevated. My entire back, upper arms, and chest were covered in cystic acne and now i'm 100 percent clear. The GH and mt2 makes my skin look even better too.