"1,4,6-androstatriene-3,17-dione (ATD), the target compound,
is known to inhibit the aromatization of androgens to estrogens
by a process called aromatization.1 In vivo, an injection of ATD
caused inhibition of ovarian aromatase and reduced estrogens
secretion in pregnant mare’s serum gonadotropin-primed rats
for at least 24 hr after injection.2 ATD was used for sequential
cancer drug due to the estrogen,3 but if abused, an occurring
side effect could be bisexuality4 and sexual dysfunction.5 Because
the ATD drug can be easily purchased on the internet for
muscle and endurance growth in an athlete, it can be easily misused.
Therefore, it was included as a banned drug at the International
Natural Bodybuilding and Fitness Federation (INBF)
in 2006 year.6 Even if not listed the World Anti-Doping agency
(WADA) in 2008, classifies the administration of ATD in sports
as doping due to the aromatase inhibiting properties. Even
though, Parr et al presented the metabolite study of ATD on
Manfred Donike workshop (25th Cologne workshop on Dope
Analysis),7 The time that ATD and ATD-M remained in human
body were investigated through the result of investigating the
excretion of ATD and its metabolite. Especially, the time that
chemicals were all consumed could be assumed as the time
that the metabolites were not detected."
1."Regardless of whether the rats got testosterone or not, the ATD made them lighter. And their testicles got smaller too. So in this experiment ATD did exactly the opposite of what the American manufacturers had claimed. The Swedes hint at why this might be: "ATD, in addition to inhibit aromatase, also may affect the binding of testosterone to the androgen receptor", they write."
