Crashed estradiol with stupid doctor

[Joints]

Hi. Im not on trt. My test was 600 and e2 was 60. I went to doctor and he put me on arimidex 1 mg a day. I took 2 days ( total 2 mg ) so in here, I saw it is too much! I stopped and 3 days later I went to cycle but my joints are in pain when I walk or sit down. After stopped arimidex, 1.5 weeks later this joint pain was started.

I was in pain with leg joint for 1 weeks but it stopped after 1 weeks. Today was 1.5 months after arimidex and i quit on cycle went pct, I am on pct now and my arm joints still in pain. My fingers too!

What should I do guys? When I take arimidex my hpta was working, and ive heard if hpta works, estradiol crash wont happen. Is that true? I guess not

 

[Milton]

Interesting Doc.

 

[JimiThing]

Yeah I agree Milton. This whole scenario makes little to no sense.
OP your first step needs to be blood work. You have to see where your hormone levels are presently before you can determine a proper course of action.

 

[JimiThing]

why e2 is important for joints?

Joint pain and stiffness is a symptom of low e2.

 

[halfape211]

I know that but why?

Although doctors are still unclear exactly how hormones, particularly estrogen, affect joints, most are resigned to the fact that estrogen (specifically a diminished level of estrogen) plays a major role in joint pain.

Estrogen affects joints by keeping inflammation down. Inflammation is a leading cause of joint pain.

 

[halfape211]

Hi. Im not on trt. My test was 600 and e2 was 60. I went to doctor and he put me on arimidex 1 mg a day. I took 2 days ( total 2 mg ) so in here, I saw it is too much! I stopped and 3 days later I went to cycle but my joints are in pain when I walk or sit down. After stopped arimidex, 1.5 weeks later this joint pain was started.

I was in pain with leg joint for 1 weeks but it stopped after 1 weeks. Today was 1.5 months after arimidex and i quit on cycle went pct, I am on pct now and my arm joints still in pain. My fingers too!

What should I do guys? When I take arimidex my hpta was working, and ive heard if hpta works, estradiol crash wont happen. Is that true? I guess not

Can you explain what you are saying in the last line?. "When I take arimidex my hpta was working."

 

[JimiThing]

Can you explain what you are saying in the last line?. "When I take arimidex my hpta was working."

It seemed to me like his doc prescibed the dex to lower his e2 but as you know an ai will also raise T via negative feedback so I was assuming thats what he meant. The whole thing doesn't make much sense. I dont know of many if any docs that would have prescribed him adex at that dosage with #'s like he walked in to the office with. Doesn't make much sense to me to be honest.

 

[Mprtz]

Did you suggest the adex to this doc or did he come up with that on his own? I believe 1mg per day is the standard dose for on-label use in females with breast cancer...

 

[Zymurgist]

Arimidex (Anastrozole )

Dosing: Adult
Breast cancer, advanced: Postmenopausal females: Oral: 1 mg once daily; continue until tumor progression

Breast cancer, early (adjuvant treatment): Postmenopausal females: Oral: 1 mg once daily. Note: The American Society of Clinical Oncology (ASCO) guidelines for Adjuvant Endocrine Therapy of Hormone-Receptor Positive Breast Cancer (Focused Update) recommend a maximum duration of 5 years of aromatase inhibitor (AI) therapy for postmenopausal women; AIs may be combined with tamoxifen for a total duration of up to 10 years of endocrine therapy. Refer to the guidelines for specific recommendations based on menopausal status and tolerability (Burstein, 2014).

Breast cancer, risk reduction (off-label use): Postmenopausal females ***8805;40 years: Oral: 1 mg once daily for 5 years (Cuzick, 2014)

 

[oldmusclemike]

Just a question here?
Who's thread is this?
What happened to OP?

 

[Mad- scientist]

The answer to most of these questions is to get blood work and to adjust your AI dosage accordingly. Estrogen is hard to control it might take a couple changes in the dosage to finally get to that sweet spot.

 

[halfape211]

Joints never came back. He was in pain. I think he gave up and went on PCT.

 

[halfwit]

It's not estradiol.


No testosterone or other AAS = closed negative feedback loop.

This means that he can take all the adex he wants, and he'll just reach a point of diminishing returns. Testosterone will go up some, and sure, estradiol will come down some - but with the loop closed; I'd be surprised if any crashing happened.

Now if there was something like HCG or AAS involved, I'd take a closer look. Otherwise, I'm calling this psychosomatic.

My .02c

 

[halfape211]

It's not estradiol.


No testosterone or other AAS = closed negative feedback loop.

This means that he can take all the adex he wants, and he'll just reach a point of diminishing returns. Testosterone will go up some, and sure, estradiol will come down some - but with the loop closed; I'd be surprised if any crashing happened.

Now if there was something like HCG or AAS involved, I'd take a closer look. Otherwise, I'm calling this psychosomatic.

My .02c

Hey Halfwit! I just want to learn something if I could. So you're saying he's on PCT and not making test or injecting test. OK. Closed feedback loop. I assume his body has some Estrogen in it. Therefore when he takes some AI, I assume the AI gets rid of some of what Estrogen is in his body during PCT. Therefore if he continues to take more AI, I would have thought, his Estrogen would decrease until he crashes. I'm not challenging your knowledge or if you are correct. I'm sure you're correct. Can you explain the logic in why there would not be ever lowering level of E2, with the continued use of AI. I don't want to ill advise anyone on this in the future. And you have me curious too.


For instance if someone was getting Test injected, their loop would be shut down as well?? But they would have E2 levels in their blood. And the E2 could lowered enough for a crash. What am I missing? ( Why do I feel like I'm going to feel like an idiot very soon?)

 

[JimiThing]

It's not estradiol.


No testosterone or other AAS = closed negative feedback loop.

This means that he can take all the adex he wants, and he'll just reach a point of diminishing returns. Testosterone will go up some, and sure, estradiol will come down some - but with the loop closed; I'd be surprised if any crashing happened.

Now if there was something like HCG or AAS involved, I'd take a closer look. Otherwise, I'm calling this psychosomatic.

My .02c

Yeah but he prob never reached that point. I think he said it was only like 6-8 weeks (he may have said 1.5-2months). Thats probably close to where that point of diminishing returns would be starting so in his mind had he continued so would the effects he was experiencing.

 

[halfwit]

Hey Halfwit! I just want to learn something if I could. So you're saying he's on PCT and not making test or injecting test. OK. Closed feedback loop. I assume his body has some Estrogen in it. Therefore when he takes some AI, I assume the AI gets rid of some of what Estrogen is in his body during PCT. Therefore if he continues to take more AI, I would have thought, his Estrogen would decrease until he crashes. I'm not challenging your knowledge or if you are correct. I'm sure you're correct. Can you explain the logic in why there would not be ever lowering level of E2, with the continued use of AI. I don't want to ill advise anyone on this in the future. And you have me curious too.


For instance if someone was getting Test injected, their loop would be shut down as well?? But they would have E2 levels in their blood. And the E2 could lowered enough for a crash. What am I missing? ( Why do I feel like I'm going to feel like an idiot very soon?)

Ah hah! JimiThing caught what I missed. I didn't catch the part of the cycle that was aborted, so he likely would be suppressed still. Now it makes sense.

Assuming he had been on just an AI monotherapy, and exogenous hormones had not been introduced, his HPTA would continue to generate more testosterone, which would be converted to estradiol until the effectiveness of the conversion satisfies his hypothalamus.

Hypogonadal guys can sometimes achieve decent test levels this way, which is what I speed read through, and made the assumption. In his case, the loop would likely still be open, and testosterone would not be converted - decreasing estradiol to abysmal levels.

Mea culpa, I'm the idiot here.

Yeah but he prob never reached that point. I think he said it was only like 6-8 weeks (he may have said 1.5-2months). Thats probably close to where that point of diminishing returns would be starting so in his mind had he continued so would the effects he was experiencing.

Thanks for catching that Jimi. You're totally right, and he just needs to ride out the PCT without any AI.

 

[halfape211]

Ah hah! JimiThing caught what I missed. I didn't catch the part of the cycle that was aborted, so he likely would be suppressed still. Now it makes sense.

Assuming he had been on just an AI monotherapy, and exogenous hormones had not been introduced, his HPTA would continue to generate more testosterone, which would be converted to estradiol until the effectiveness of the conversion satisfies his hypothalamus.

Hypogonadal guys can sometimes achieve decent test levels this way, which is what I speed read through, and made the assumption. In his case, the loop would likely still be open, and testosterone would not be converted - decreasing estradiol to abysmal levels.

Mea culpa, I'm the idiot here.



Thanks for catching that Jimi. You're totally right, and he just needs to ride out the PCT without any AI.

It's OK big guy! You could have just bullshitted your way out of it with a few medical terms and I might believed you.

 

[Joints]

hey im on pct. my balls is bigger i think my testicles is working (thank god)

Leg joints - OK
Fingers - not bad
Arm joins - this is the issue.

I have a question. seems like my balls working , it means my estradiol is okay now ? since i start pct i feel garbage

 

[halfwit]

It's OK big guy! You could have just bullshitted your way out of it with a few medical terms and I might believed you.

Haha, not if I want to be credible. Too many buddies here that would call me on it LOL.