Do SARMs reduce androgen side effects of other steroids?
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STAUNCHED427
Elite Juicer
SERMS typically won't reduce anything but prevent estrogen from binding to breast tissue, otherwise they still leave high levels of estrogen in the blood which causes sides. An aromatase inhibitor is what you want to reduce and control estrogen.
SARMS, as far as I am aware but if I am wrong somebody chime in will not reduce androgenic side effects from steroids and are slightly androgenic themselves. However, I think some have affinity for prostate in which they antagonise receptors there obviously as a treatment for prostate cancer.
SARMS, as far as I am aware but if I am wrong somebody chime in will not reduce androgenic side effects from steroids and are slightly androgenic themselves. However, I think some have affinity for prostate in which they antagonise receptors there obviously as a treatment for prostate cancer.
JimiThing
Moderator
Is the binding affinity of sarms stronger than the binding affinity of actual androgens at the androgen receptor sites on the prostate? Thats what makes serms effective at say gyno prevention/treatment - they have a stronger binding affinity to the e receptor in breast tissue than estrogen itself. (psizzle feel free to jump in as I know you are well versed in sarms and their various effects)
psizzle_8
New member
As far as the prostate is concerned..
You've heard of the positive effects on bone density with sarms usage, right? Here's some info that coincides with that and the issue of the prostate:
For example, if the target is bone growth in elderly men with osteopenia or osteoporosis, but with no overt signs of hypogonadism, a SARM targeting bone and muscle tissue but with lesser activity on the prostate or testes would be more desirable.
...in other words, those positive effects they're after with sarms won't be risking bad sides with their prostate and male parts.
A SARM for women would ideally stimulate bone retention, or libido and other sexual function that androgens can influence, without negative side-effects such as development of male gender characteristics (virilization), increased LDL/HDL ratios, liver dysfunction, and so forth.
...same as above except with women.
AND...a piece from my own informative thread:
However, SARMS don't offer negative side effects such as those on the prostate or other sexual organs.
Link to my thread: http://www.steroidology.com/forum/a...sarms-info-thread-hosted-sarmssearch-com.html
^ read up on this guys. I didn't post it for my health lol it can answer questions you have regarding sarms!
You've heard of the positive effects on bone density with sarms usage, right? Here's some info that coincides with that and the issue of the prostate:
For example, if the target is bone growth in elderly men with osteopenia or osteoporosis, but with no overt signs of hypogonadism, a SARM targeting bone and muscle tissue but with lesser activity on the prostate or testes would be more desirable.
...in other words, those positive effects they're after with sarms won't be risking bad sides with their prostate and male parts.
A SARM for women would ideally stimulate bone retention, or libido and other sexual function that androgens can influence, without negative side-effects such as development of male gender characteristics (virilization), increased LDL/HDL ratios, liver dysfunction, and so forth.
...same as above except with women.
AND...a piece from my own informative thread:
However, SARMS don't offer negative side effects such as those on the prostate or other sexual organs.
Link to my thread: http://www.steroidology.com/forum/a...sarms-info-thread-hosted-sarmssearch-com.html
^ read up on this guys. I didn't post it for my health lol it can answer questions you have regarding sarms!
Yes, SARMs may be slightly androgenic themselves, but if they are less androgenic than androgens produced by some other steroids, while having a higher affinity for the androgen receptors, aren't we essentially preventing those stronger androgens from binding, and thus lowering the androgen side effect potential of a particular steroid in combination with the SARM?
JimiThing
Moderator
This is quite the leap of speculation especially given that in the presence of excess androgens of any kind the AR half life doubles as does the rate of production for new ARs. In other words - no way you can say this....
My prostate question was never answered. Your original question is totally dependent upon the answer to my question. Very interesting topic for discussion. Ill look into it further. I think circumstance plays a role as well. Are you talking when just taking sarms or talking sarms with exogenous androgen (ie test/deca winny whatever) etc. I dont think a sarm is going to block the receptor site in the prostate preventing androgenic effects of say dht like serms block e receptor in breast tissue Sarms target desirable androgen receptors where you want androgenic effects exerted and bind to them and not to those androgen receptors where you do not. Thus I think the entire sarm/serm analogy is flawed and so is all the speculation be drawn along with it.
I don't know the answer to the question. I'm interested in more than just practical usage of these substances.
I'm talking about when you stack a SARM with another steroid.
Basically, if we can substitute less potent androgens but with better binding for the more potent androgens of other steroids.
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STAUNCHED427
Elite Juicer
Jimi, I'm pretty sure it is now recognised that estrogen is the problem when it comes to the prostate, not androgens. Hence why SERMS which antagonise the prostate have a potential in prostate cancer prevention... Actually treatment for that matter as I am pretty sure there is a study showing Raloxifene binds and reduces or kills something to do with the prostate.
I'll try find the study.
But in answer to your original question, I'm pretty sure a SARM is no match for strong androgens, like Tren for example. But I'm pretty sure that the AR upregulates when it is agonised and downregulates when their is not enough agonism (to be specific, new receptors pop up and actually sensitise). I wonder if the same if true for ER... I would assume so.
I'll try find the study.
But in answer to your original question, I'm pretty sure a SARM is no match for strong androgens, like Tren for example. But I'm pretty sure that the AR upregulates when it is agonised and downregulates when their is not enough agonism (to be specific, new receptors pop up and actually sensitise). I wonder if the same if true for ER... I would assume so.
bushleaguechew
Junior Bodybuilder
Both androgen and estrogen receptors down regulate with excessive stimulation and up regulate with inadequate stimulation.
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