does finastride decrese muscle hardness,vascularity and strentgh?
- Thread starter 3dwin
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scorob777
New member
Check out what happened to group #4 - oral finasteride. "The tissue weights of the corpus cavernosum and prostate were reduced by 25.9% and 92.3% in group 4 compared with group 1". Humans are not rats, but do you want to mess with a drug widely rumored to shrink your dick?
And the 2nd and 3rd study below also show deleterious effects on your willy.
Effects of oral finasteride on erectile function in a rat model.
Zhang MG1, Wu W, Zhang CM, Wang XJ, Gao PJ, Lu YL, Shen ZJ.
Author information
Abstract
INTRODUCTION:
Many clinical studies reported finasteride-related erectile dysfunction, but to date, few animal experiments have focused on it.
AIM:
To investigate the effects of oral finasteride on erectile function in a rat model.
MAIN OUTCOME MEASURES:
Erectile responses and morphological changes.
METHODS:
Adult, male Sprague-Dawley rats were divided into four groups (25/group): (i) control; (ii) castration; (iii) castration with testosterone (T) replacement; and (iv) oral finasteride treatment. Four weeks later, erectile function was measured by the ratio of intracavernosal pressure and mean arterial blood pressure upon electrical stimulation of the cavernous nerve. Serum T and dihydrotestosterone (DHT) and intraprostatic DHT were measured. The weights and histopathological features of the penile corpus cavernosum and prostate were examined.
RESULTS:
Serum T and DHT and intraprostatic DHT concentrations, erectile function, and mean weights of the corpus cavernosum and prostate were lowest in group 2. There was no significant difference in the serum T concentration and erectile function between groups 4 and 1. However, the serum and intraprostatic DHT concentrations were significantly lower in group 4 than in group 1 (both P < 0.001). The tissue weights of the corpus cavernosum and prostate were reduced by 25.9% and 92.3% in group 4 compared with group 1 (both P < 0.001). Histopathology revealed a significant atrophy of the prostate in groups 2 and 4. There was a significant decrease in the smooth muscle content in group 2, but not in groups 3 and 4.
CONCLUSIONS:
In a rat model, finasteride treatment for 4 weeks reduces the weight of the corpus cavernosum but appears not to affect the erectile responses to electrical stimulation of the cavernous nerve. As erection is a complex process involving important signaling in the brain, further studies are necessary to demonstrate the long-term effects of finasteride on both central and peripheral neural pathways of erection.
Here's another one:
Long-term Oral Administration of 5***945;-reductase Inhibitor Attenuates Erectile Function by Inhibiting Autophagy and Promoting Apoptosis of Smooth Muscle Cells in Corpus Cavernosum of Aged Rats
Author links open overlay panelMin-GuanZhangabXian-JinWangbZhou-JunShenbPing-JinGaoa
https://doi.org/10.1016/j.urology.2013.02.045
Get rights and content
Objective
To investigate the effects and mechanisms of long-term treatment of 5***945;-reductase inhibitors (5ARIs) on erectile organ structure and function in aged rats.
Materials and Methods
Thirty 16-month-old male rats were assigned to 2 groups: untreated or treated with 5ARIs. After 16 weeks, the erectile function was measured after electrical stimulation of the cavernous nerve. The weights and histopathologic features of the corpus cavernosum were examined. The levels of autophagy, apoptosis, and protein expression were also recorded.
Results
In the 5ARI-treatment group, the plasma and intraprostatic dihydrotestosterone concentration was lowered by 52.1% and 57.3%, respectively, and the weight of the corpus cavernosum and prostate had decreased by 22.4% and 35.6%, respectively. The in vivo erectile response to electrical stimulation of the cavernous nerve had decreased significantly in the 5ARI-treatment group (P <.001). Masson's staining, immunohistochemistry, and Western blot all demonstrated decreased smooth muscle and increased collagen deposition and decreased endothelial nitric oxide synthase and LC3-II protein expression in the corpus cavernosum of the 5ARI-treatment group. Using transmission electron microscopy and terminal deoxynucleotidyl transferase-mediated deoxyuridine triphosphate nick end labeling, decreased autophagy, aggravated ultrastructural injury of mitochondria, and increased apoptosis were observed in the cavernous smooth muscle cells from the rats in the 5ARI-treatment group.
Conclusion
Long-term 5ARI treatment did attenuate the erectile function of aged rats. The mechanisms might have been the decreased rate of autophagy and an increased rate of apoptosis in the cavernous smooth muscle cells, suggesting a new role for androgen in maintaining the structural and functional integrity of the erectile organ. Additional studies are necessary to demonstrate the mechanisms of dihydrotestosterone in regulating the autophagy and apoptosis of the cavernous smooth muscle cells.
Here's a third one:
4 Discussion
The present study showed that in the castration animals, there were a high degree of fibrosis in the corpus cavernosum with irregularly arranged collagenous fibers and a marked decrease in smooth muscle fibers, while in the DHT-inhibited group, the corpus cavernosum contained quite an amount of thick and irregular-arranged collagenous fibers, but the degree of fibrosis was lower than that in the castration group. Results suggest that androgen is essential for the maintenance of normal ultrastructure of corpus cavernosum. Zhang et al [4] demonstrated that in mature rats, castration induced apoptosis in corpus cavernosum with the replacement of the apoptotic tissues by fibrous tissue. This may be one of the pathways through which androgen deprivation acts on corpus cavernosum. In the present study, the degree and type of corpus cavernosum fibrosis in the two groups were different, suggesting that T and DHT act on the corporal cavernosal tissues independently and differently. Finasteride can only inhibit the action of DHT, but not T on the corporal cavernosal tissue, therefore, the degree of fibrosis was less in the DHT-inhibited group than in the castration group.
The tunica albuginea of penis plays a major role in the erection mechanism. It compresses the subalbugineal venules, thus decreasing the venous outflow during erection and provides an inextensible fibrous frame for the erectile tissue of the penis [5]. In the normal control group of this study, the elastic fibers in the tunica albuginea were very rich and arranged regularly and undulatedly. In the castration group, the thickness of tunica albuginea decreased significantly and the elastic fibers were mostly replaced by collagenous fibers and in the DHT-inhibited group, the elastic fibers were replaced by disorganized and thick collagenous fibers. These results indicate that androgen is also essential for the maintenance of the normal structures of tunica albuginea.
It can be concluded that androgen is indispensable to the maintenance of normal ultrastructures of the erectile tissues. However, the interrelationship between androgen and the structure and function of the erectile tissue is not quite clear and sometimes even controversial, and further investigation is needed.
And the 2nd and 3rd study below also show deleterious effects on your willy.
Effects of oral finasteride on erectile function in a rat model.
Zhang MG1, Wu W, Zhang CM, Wang XJ, Gao PJ, Lu YL, Shen ZJ.
Author information
Abstract
INTRODUCTION:
Many clinical studies reported finasteride-related erectile dysfunction, but to date, few animal experiments have focused on it.
AIM:
To investigate the effects of oral finasteride on erectile function in a rat model.
MAIN OUTCOME MEASURES:
Erectile responses and morphological changes.
METHODS:
Adult, male Sprague-Dawley rats were divided into four groups (25/group): (i) control; (ii) castration; (iii) castration with testosterone (T) replacement; and (iv) oral finasteride treatment. Four weeks later, erectile function was measured by the ratio of intracavernosal pressure and mean arterial blood pressure upon electrical stimulation of the cavernous nerve. Serum T and dihydrotestosterone (DHT) and intraprostatic DHT were measured. The weights and histopathological features of the penile corpus cavernosum and prostate were examined.
RESULTS:
Serum T and DHT and intraprostatic DHT concentrations, erectile function, and mean weights of the corpus cavernosum and prostate were lowest in group 2. There was no significant difference in the serum T concentration and erectile function between groups 4 and 1. However, the serum and intraprostatic DHT concentrations were significantly lower in group 4 than in group 1 (both P < 0.001). The tissue weights of the corpus cavernosum and prostate were reduced by 25.9% and 92.3% in group 4 compared with group 1 (both P < 0.001). Histopathology revealed a significant atrophy of the prostate in groups 2 and 4. There was a significant decrease in the smooth muscle content in group 2, but not in groups 3 and 4.
CONCLUSIONS:
In a rat model, finasteride treatment for 4 weeks reduces the weight of the corpus cavernosum but appears not to affect the erectile responses to electrical stimulation of the cavernous nerve. As erection is a complex process involving important signaling in the brain, further studies are necessary to demonstrate the long-term effects of finasteride on both central and peripheral neural pathways of erection.
Here's another one:
Long-term Oral Administration of 5***945;-reductase Inhibitor Attenuates Erectile Function by Inhibiting Autophagy and Promoting Apoptosis of Smooth Muscle Cells in Corpus Cavernosum of Aged Rats
Author links open overlay panelMin-GuanZhangabXian-JinWangbZhou-JunShenbPing-JinGaoa
https://doi.org/10.1016/j.urology.2013.02.045
Get rights and content
Objective
To investigate the effects and mechanisms of long-term treatment of 5***945;-reductase inhibitors (5ARIs) on erectile organ structure and function in aged rats.
Materials and Methods
Thirty 16-month-old male rats were assigned to 2 groups: untreated or treated with 5ARIs. After 16 weeks, the erectile function was measured after electrical stimulation of the cavernous nerve. The weights and histopathologic features of the corpus cavernosum were examined. The levels of autophagy, apoptosis, and protein expression were also recorded.
Results
In the 5ARI-treatment group, the plasma and intraprostatic dihydrotestosterone concentration was lowered by 52.1% and 57.3%, respectively, and the weight of the corpus cavernosum and prostate had decreased by 22.4% and 35.6%, respectively. The in vivo erectile response to electrical stimulation of the cavernous nerve had decreased significantly in the 5ARI-treatment group (P <.001). Masson's staining, immunohistochemistry, and Western blot all demonstrated decreased smooth muscle and increased collagen deposition and decreased endothelial nitric oxide synthase and LC3-II protein expression in the corpus cavernosum of the 5ARI-treatment group. Using transmission electron microscopy and terminal deoxynucleotidyl transferase-mediated deoxyuridine triphosphate nick end labeling, decreased autophagy, aggravated ultrastructural injury of mitochondria, and increased apoptosis were observed in the cavernous smooth muscle cells from the rats in the 5ARI-treatment group.
Conclusion
Long-term 5ARI treatment did attenuate the erectile function of aged rats. The mechanisms might have been the decreased rate of autophagy and an increased rate of apoptosis in the cavernous smooth muscle cells, suggesting a new role for androgen in maintaining the structural and functional integrity of the erectile organ. Additional studies are necessary to demonstrate the mechanisms of dihydrotestosterone in regulating the autophagy and apoptosis of the cavernous smooth muscle cells.
Here's a third one:
4 Discussion
The present study showed that in the castration animals, there were a high degree of fibrosis in the corpus cavernosum with irregularly arranged collagenous fibers and a marked decrease in smooth muscle fibers, while in the DHT-inhibited group, the corpus cavernosum contained quite an amount of thick and irregular-arranged collagenous fibers, but the degree of fibrosis was lower than that in the castration group. Results suggest that androgen is essential for the maintenance of normal ultrastructure of corpus cavernosum. Zhang et al [4] demonstrated that in mature rats, castration induced apoptosis in corpus cavernosum with the replacement of the apoptotic tissues by fibrous tissue. This may be one of the pathways through which androgen deprivation acts on corpus cavernosum. In the present study, the degree and type of corpus cavernosum fibrosis in the two groups were different, suggesting that T and DHT act on the corporal cavernosal tissues independently and differently. Finasteride can only inhibit the action of DHT, but not T on the corporal cavernosal tissue, therefore, the degree of fibrosis was less in the DHT-inhibited group than in the castration group.
The tunica albuginea of penis plays a major role in the erection mechanism. It compresses the subalbugineal venules, thus decreasing the venous outflow during erection and provides an inextensible fibrous frame for the erectile tissue of the penis [5]. In the normal control group of this study, the elastic fibers in the tunica albuginea were very rich and arranged regularly and undulatedly. In the castration group, the thickness of tunica albuginea decreased significantly and the elastic fibers were mostly replaced by collagenous fibers and in the DHT-inhibited group, the elastic fibers were replaced by disorganized and thick collagenous fibers. These results indicate that androgen is also essential for the maintenance of the normal structures of tunica albuginea.
It can be concluded that androgen is indispensable to the maintenance of normal ultrastructures of the erectile tissues. However, the interrelationship between androgen and the structure and function of the erectile tissue is not quite clear and sometimes even controversial, and further investigation is needed.
Dreaded Pirate Roberts
Administrator
Finasturide was widely used with cycles about 10 years ago. One of the effects is higher Total test levels as it blocks the conversion to DHT.
With test you are good to go and no hair loss. Ive never heard of anyones dick shrinking. It losers no2 levels a little and that is responsible for some Ed issues without test.
With test you are good to go and no hair loss. Ive never heard of anyones dick shrinking. It losers no2 levels a little and that is responsible for some Ed issues without test.
Last edited:
3J
Super Moderator
relax guys.. it "shrinks your dick" because finasteride blocks dht..
your dick functions off your hormones like test, estrogen, progestrone, and dht.. if one of them is out of wack aka "dht" you wouldn't experience strong erections..
your dick doesn't actually get "smaller" lol
your dick functions off your hormones like test, estrogen, progestrone, and dht.. if one of them is out of wack aka "dht" you wouldn't experience strong erections..
your dick doesn't actually get "smaller" lol
IMT
IMT Rep
hell, we got newbies all over the place here chemically castrating themselves, and they are all willingly doing it. go figure. its a brave new world out there.
Dreaded Pirate Roberts
Administrator
Finasturide doesn't effect the size of your cock. what it does is effect the bodies conversiton of akg to No2 which is a easily adjusted with a little added L-arginine
IMT
IMT Rep
Yes mr. Santa people do take stuff that shrink their dicks. I wish the younger lads who view this site can clearly see this point as when i was 18 and younger i was getting busy with two or three girls per day and had to have my johnson ready at all times.
Nothing worst that getting a hot and willing girl in bed and mr. williy wonka is out to lunch.
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