'Gene Doping' Poll
- Thread starter soonbebig
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Johny J
never gonna be a ***
Dr.X said:
damn it. Dont make me crack my books and blow dust everywhere. Its been 2 years since my genetics and micro courses. Damn, i got my head all messed up now. If i remember correctly, restriction enzymes are a degrative enzyme that recognizes and cuts up dna. What you go t me fuzzy on now was how it recognizes that dna. If it can rcognize specific dna fragments, why wouldnt that work. Now if they recognize specific base pairings, i see where you are coming from. I know restriction enzymes can recognize foreign dna (possibly from a virus) and destroy them. Give me a refresher if you dont mind.
Shit man, you are gonna make me break out my genetics books and go over this.
Dr.X
New member
Only talking about the reason I gave for it not working, most restriction enyzmyes recognize 4-6 base pair sequences of dna. Therefore, any such restriction site in the genomic dna would be cleaved (not just myostatin). We're not even talking about the other million problems.
Honestly, I think gene therapy is possible, not through the methods you suggest but rather through RNAi or the like.
Right now the "best" way if someone were to try to inhibit myostatin function would be to use neutralizing antibodies. Based on mouse models, if I remember correctly this would equate to a ridiculous dose of like 5g/d.
Honestly, I think gene therapy is possible, not through the methods you suggest but rather through RNAi or the like.
Right now the "best" way if someone were to try to inhibit myostatin function would be to use neutralizing antibodies. Based on mouse models, if I remember correctly this would equate to a ridiculous dose of like 5g/d.
Johny J
never gonna be a ***
Dr.X said:
ok. so the restriction enzymes would indiscriminatly chop up all dna that contains said restriction sites. That would be a genetic disaster, although a quite effecive bio weapon
and as far as blocking all those enzymes produces, you would probably have to drink a gallon of that shit a day to get the effect. So something tells me they found a way to deactivate the myostatin gene directly.
i7readbhlb
New member
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SomeBloke
Midnight Rodeo
you guys would be nuts to rewrite your DNA before the long term implications have been studied. ever considered that some muscles would change that you wouldnt want to change? face? jaw?
using an inhibitor, or some sort of competitive antagonist or something, sure, i can see that. its reversible, probably safer, much neater (apart from the dosing) and the way to go
no way in hell i would rewrite my genetic code, fuck that.
using an inhibitor, or some sort of competitive antagonist or something, sure, i can see that. its reversible, probably safer, much neater (apart from the dosing) and the way to go
no way in hell i would rewrite my genetic code, fuck that.
majic
New member
Well, as the article suggests, researchers don't know if Myostatin is to blame for muscle loss, or if it is responsible for muscle regeneration. As the author was saying, it was found in high concentrations in dead cardiac muscle cells -- which means one of two things: either myostatin was released in that localized area to try to regenerate the damaged or dying muscle, or the muscle died in the presence of myostatin.
Additionally, the point was raised that two things have to happen to make the connection of myostatin inhibition and muscle hypertrophy: a) that the administration of myostatin does, in fact, cause loss of muscle mass, and b) that the suppression of myostatin does, in practice, cause an increase in muscle mass without adversely affecting other non-skeletal muscles.
Additionally, the point was raised that two things have to happen to make the connection of myostatin inhibition and muscle hypertrophy: a) that the administration of myostatin does, in fact, cause loss of muscle mass, and b) that the suppression of myostatin does, in practice, cause an increase in muscle mass without adversely affecting other non-skeletal muscles.
jarbulldog
bulldog god
i would do it if the sides were low
Frankie xq
New member
just let everyone know, those mice were genetically altered before they were even born. not after. changing your genes isn't hard, all it takes is a mutagen like cigarette smoke to do it. but i've yet to hear of a beneficial mutagen.
nadaadvegnado
New member
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