IGF Des seeking knowledge

PureIsClean

PureIsClean

New member
Someone know where a thread lying around covering IGF DES? I'll be starting soon and looking to soak up as much info as I can. So any advice dosage or a thread pertaining to this would be awsome. Thank you
 
Ok bro is very eazy you need from 100-120 mcgs a day, 5 days a week and never never inject in your stomach
 
PureIsClean said:
Someone know where a thread lying around covering IGF DES? I'll be starting soon and looking to soak up as much info as I can. So any advice dosage or a thread pertaining to this would be awsome. Thank you
Click to expand...

I love igf1 lr3 and des.
i would rec des at 10-20mcg 2x a day for 6-8 weeks at a time. very nice stuff. I been researching RU|Ia igf1 for years now, love it.
 
OK need just a tad bit of clarification .5ml syringe-1ml sodium chloride, that comes to 10mcg of peptide per tick?
If that addition is correct my rats arms just took 200mcg a lick. (one hell of a damn bicep day) But recalculating my math itstelling me I should've only drew to the 4th tick to get the 40 mcg instead of to the 20th tick. Someone check my math please TY in advance <.<


(idea was to get 80 bilaterally) -edit
 
Hate to be a party pooper but seriously, IGF-1 and its analogues (LR3, Des, etc) have to be made from recombinant sources, otherwise they have 0 biologic activity if chemically synthesized. Just started a thread in this forum about it. If you are obtaining your IGF-1 from a peptide company (chemical synthesis) there is no way it will work. Same for insulin, which has the same internal fold as IGF-1 with 3 disulfide bonds. Has to be recombinant IGF-1 or recombinant IGF-1 LR3, which is crazy expensive and nearly impossible to get. I can produce lots of references in the scientific literature, not to mention that I have worked in this area in my profession.
 
I am just trying to help here. I am 100% certain that IGF-1 will not work if made by chemical synthesis, such as from a peptide company. This will upset a lot of bros that have sworn their IGF-1 regimen worked great for them, but the science is unshakable. It has to be folded correctly with 3 disulfide bonds to generate what is know as the "insulin fold", which is what is required to bind the receptor. There are dozens of studies on this. There was even a big scientific push to generate a version of IGF-1 (and insulin) that does not require cysteines and these 3 disulfide bonds, but it turned out to be impossible. The protein has to be made recombinantly......meaning that IGF-1 and insulin are only folded correctly if generated from a biologic source, like bacteria. All Insulin (humalin, etc) is made from biologic sources, meaning in bacteria (E.coli) in huge fermentors. My guess is that 95% of the IGF analogues we are using as a BB community has 0 activity. Swear it works all you want, but it cant be working through the IGF-1 receptor.
 
I disagree with Moppy 100%, as well as the articles he is posting and referring to. I have never ran DES but have ran 2 cycle with IGF LR3 with unbelievable results, muscle fullness and pumps and growth were unbelievable. All my IGF was purchased through the peptide company I deal with. I have first hand experience and i can tell you dont bother buying into these articles. I know your wanting knowledge of DES and im sorry but i have zero experience with that, but do have experience with IGF 1 LR3 and it works like a MFer no ifs ands of buts.
 
Schredder said:
I disagree with Moppy 100%, as well as the articles he is posting and referring to. I have never ran DES but have ran 2 cycle with IGF LR3 with unbelievable results, muscle fullness and pumps and growth were unbelievable. All my IGF was purchased through the peptide company I deal with. I have first hand experience and i can tell you dont bother buying into these articles. I know your wanting knowledge of DES and im sorry but i have zero experience with that, but do have experience with IGF 1 LR3 and it works like a MFer no ifs ands of buts.
Click to expand...

Not trying to discredit your experiences but have you performed blood work to know for sure? I've yet to look at the references of the abstracts posted but after a quick glance he is right on the science but again, further reading is needed

PureIsClean said:
Thx shredder, the pumps are what's seems to tell me it's legitimate .
Click to expand...

The pumps can be from anything. Pumps don't mean that IGF-1 xxx is active and activating cellular receptors. Pumps don't equate to growth or progress either so why buy such an expensive compound for 'pumps'. Cialis will give you plenty of pump
 
Schredder said:
I disagree with Moppy 100%, as well as the articles he is posting and referring to. I have never ran DES but have ran 2 cycle with IGF LR3 with unbelievable results, muscle fullness and pumps and growth were unbelievable. All my IGF was purchased through the peptide company I deal with. I have first hand experience and i can tell you dont bother buying into these articles. I know your wanting knowledge of DES and im sorry but i have zero experience with that, but do have experience with IGF 1 LR3 and it works like a MFer no ifs ands of buts.
Click to expand...

I really have no axe to grind here whatsoever, nor any agenda. I am a scientist and I work in this area. Just trying to help you guys. If you think your peptide source works, then keep at it!

But you might want to look into the science of all this and keep an open mind:

Try these references:
Probing the disulfide folding pathway of i... [Biotechnol Bioeng. 1999] - PubMed - NCBI
Refolding of amphioxus insulin-like peptide: im... [Biochemistry. 2003] - PubMed - NCBI
The different folding behavior of insulin and i... [Biochemistry. 2002] - PubMed - NCBI
Effects of L-arginine on refolding of... [Bioprocess Biosyst Eng. 2012] - PubMed - NCBI
Probing the folding pathways of long R(3) insuli... [J Biol Chem. 1999] - PubMed - NCBI
Insulin-like growth factors I and II are unable to... [FEBS Lett. 1999] - PubMed - NCBI
Affinity-assisted in vivo folding of a secret... [Nat Biotechnol. 1996] - PubMed - NCBI
Effect of environment on insulin-lik... [Biotechnol Appl Biochem. 1994] - PubMed - NCBI
Development of an optimized refolding process fo... [Protein Eng. 1992] - PubMed - NCBI

SOme are more historical references when the scientific community was trying to learn how to correctly refold IGF-1 generated in E.coli, which was not easy. Now it is more routine, but still very expensive to produce and make properly
 
Too early for growth to be noticed and you are right about the pumps idk just felt different then normal. You know your own body better than anyone but I've researched the company they were not cheap and I'm convinced they were made with legitimate recombinant sources. I greatly appreciate the references Moppy1 it's always better to be able to back up your inputs from knowledgeable sources. TYVM
 
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