Is SARM administration something being worked on...

[SCG2]

...by you rogue chemists out there?

Selective androgen receptor modulator treatment improves muscle strength and body composition and prevents bone loss in orchidectomized rats.

* Gao W,
* Reiser PJ,
* Coss CC,
* Phelps MA,
* Kearbey JD,
* Miller DD,
* Dalton JT.

Division of Pharmaceutics, College of Pharmacy and Department of Oral Biology, The Ohio State University, 500 West 12th Avenue, L. M. Parks Hall, Room 242, Columbus, Ohio 43210, USA.

The partial agonist activity of a selective androgen receptor modulator (SARM) in the prostate was demonstrated in orchidectomized rats. In the current study, we characterized the full agonist activity of S-3-(4-acetylamino-phenoxy)-2-hydroxy-2-methyl-N-(4-nitro-3-trifluoromethyl-phenyl)-propionamide (a structurally related SARM referred to in other publications and hereafter as S-4) in skeletal muscle, bone, and pituitary of castrated male rats. Twelve weeks after castration, animals were treated with S-4 (3 or 10 mg/kg), dihydrotestosterone (DHT) (3 mg/kg), or vehicle for 8 wk. S-4 (3 and 10 mg/kg) restored soleus muscle mass and strength and levator ani muscle mass to that seen in intact animals. Similar changes were also observed in DHT-treated (3 mg/kg) animals. Compared with the anabolic effects observed in muscle, DHT (3 mg/kg) stimulated prostate and seminal vesicle weights more than 2-fold greater than that observed in intact controls, whereas S-4 (3 mg/kg) returned these androgenic organs to only 16 and 17%, respectively, of the control levels. S-4 (3 and 10 mg/kg) and DHT (3 mg/kg) restored castration-induced loss in lean body mass. Furthermore, S-4 treatment caused a significantly larger increase in total body bone mineral density than DHT. S-4 (3 and 10 mg/kg) also demonstrated agonist activity in the pituitary and significantly decreased plasma LH and FSH levels in castrated animals in a dose-dependent manner. In summary, the strong anabolic effects of S-4 in skeletal muscle, bone, and pituitary were achieved with minimal pharmacologic effect in the prostate. The tissue-selective pharmacologic activity of SARMs provides obvious advantages over steroidal androgen therapy and demonstrates the promising therapeutic utility that this new class of drugs may hold.

 

[Thoms]

Ah yes, SARM. Basically a classification of syndrogens, that by defenition, exert the ability to bind with the androgen receptor. It is a broad class of products, that is totally unrelated to AAS. Their tendency to bind to the androgen receptor, means there will be no actual androgenic side-effects in the body.
The study that you speak of is a rat study done on 4 SARM. Two of them, S2 and S3, showed binding to the androgen receptor, but no anabolic activity. The other two, S1 and S4 (see full name above), did show anabolic activity, with one of them (S4 I believe) having a higher anabolic effect than test prop.
Some SARM work orally, some are injectible.
I'm currently not experimenting with them, but I am keeping my eye on them. The medical community is experimenting with acetothiolutamide, and human trials with ostarine and andarine have already been done. Still pretty experimental so far, but they are considered a possible replacement to steroids in the medical community.

 

[Thoms]

So where does that leave SARM for the BB?
*SARM that inhibit androgenic sides, and are anabolic, can be taken by itself;
or
*SARM that inhibit androgenic sides, but are NOT anabolic, can be taken along with steroids. The result will be no change in anabolic activity (tests have already been done on that), and an inhibition of androgenic sides.

 

[Thoms]

So how to get them? Well, the medical community is still experimenting. But that doesn't stop the supplement industry. One product exists as SARM-X. Active ingredient is Trans-4-Hydroxy-3-Methoxycinnamic Acid.
"SARM-X is the first of a new class of designer androgenic / anabolic steroid memetic compounds; the most advanced legal over-the-counter compound available anywhere!"

Yeah. Well, on the positive side, it is in fact a SARM. On the negative side, this supplement uses a fancy name for ferulic acid, a phenol found i.e. in grains, oatmeal and brown rice. An interesting compound, but one of the SARM with zero anabolic activity. Still useful to counter androgenic sides though. Studies on that specific SARM have been done with success on deca and test, both with the SARM attached to the androgenic hormone, or taken separately.