Mk 677 study glucose side effect

[Therealkozmo]

https://www.ncbi.nlm.nih.gov/pubmed/9467542

Anyone know what this sentence means in laymens? Is it a side effect that could be a health risk?

Fasting concentrations of glucose and insulin were unchanged, whereas an oral glucose tolerance test showed impairment of glucose homeostasis at 2 and 8 weeks

 

[Roush]

https://www.ncbi.nlm.nih.gov/pubmed/9467542

Anyone know what this sentence means in laymens? Is it a side effect that could be a health risk?

Fasting concentrations of glucose and insulin were unchanged, whereas an oral glucose tolerance test showed impairment of glucose homeostasis at 2 and 8 weeks

fasting concentrations were unchanged . that means the body eventually became stable with blood glucose levels over time.

glucose tolerance test is done with the consumption of sugars. if there was an impairment that meant that when digesting sugars , at that time the body had an impairment in controlling those blood sugar levels and getting them back to stable (homeostasis).

i would conclude that with elevated GH levels , that when consuming and digesting carbs/sugars , that those sugars are not easily dealt with due to growth hormones blunting the effect of insulin. however , over a period of 24 hours and the GH pulses cease, that the blood sugar is eventually stabilized. thats why fasting blood sugar is fine , but glucose tolerance tests showed impairment

great question btw

 

[anzel]

Yeah smart question and smart answer from you both!

And here is the conclusion frof the study. (I like fast forwarding to the best part!)
.
We conclude that 2-month treatment with MK-677 in healthy obese males caused a sustained increase in serum levels of GH, IGF-I, and IGF-binding protein-3. The effects on cortisol secretion were transient. Changes in body composition and energy expenditure were of an anabolic nature, with a sustained increase in fat-free mass and a transient increase in basal metabolic rate. Further studies are needed to evaluate whether a higher dose of MK-677 or a more prolonged treatment period can promote a reduction in body fat.

 

[blakey]

Spot on the money

 

[Therealkozmo]

what negative health effects do you know of that may arise from impairment of glucose homeostasis? Has this effect been noted in any other gh or igf increasing substances?

 

[Roush]

what negative health effects do you know of that may arise from impairment of glucose homeostasis? Has this effect been noted in any other gh or igf increasing substances?

we should probably separate GH from IGF in regards to impairment of glucose homeostasis . because IGF is completely different then GH in these regards as IGF actually helps to stabilize and lower blood sugar levels and increases a persons insulin sensitivity. whereas GH can cause glucose impairment and cause insulin resistance. so they are exact opposites in these regards (even though IGF is a by product of GH).

as for the negative health issues related to impaired glucose levels, i.e., elevated blood sugar. a host of issues, from a simple headache to dizziness, vision problems , nerve damage, organ damage etc..


having ran a bunch of HGH along with GH peptides and manipulating my GH blood serum levels greatly , I've went Hyper-glycemic, its miserable . I started to lose my vision, i got dizzy and my whole body began to shake uncontrollably, my heart rate accelerated, all my limbs and legs went numb and weak and I could not walk , my whole body began to ache severely.

^ this is an extreme case , but you definitely don't want your blood glucose stability impaired severely. Looking back and learning from this experience I will not be practicing such things without having exogenous insulin available. in fact, my run of MK-677 will be used in conjunction with an insulin protocol (even though MK will not drastically increase my GH serum levels like I was doing with the peptides and HGH)

 

[appleton111]

Being hypoglycemic I can relate to alot of this and feel for those who are type-2 diabetic more now. (my own mom was type 2 and she passed from colon cancer) Mine is mild and I dont worry about keeping it in check much but when I drink booze and then eat sweets. forget about it, Its Dr Jekyll and Mr Hide time. Ive woken up in beds/jail cells/street gutters/dark alleys that I had no idea how I got there or what caused me to black out after I threw sugar into my mix.

One night long ago I was in a Mexican bar slamming down Tequila shots like there was no tomorrow, after about 12 rounds of Mexicos finest I switched to drinking every shooter on the bars shooter menu. I started downing shooter after sweet shooter, old Bill Clinton had just been elected and i was in a celebratory mood, I recall seeing some chocolate kisses on the bar and me eating them foil and all and the last thing I remember about that is me getting up on top of the bar and proclaiming to everyone in the bar that the drinks where on me!
Cut to- me running down a dark inner city alley with the sound of gun shots flying past my ears and me shooting back at whomever was shooting at me and the ever-present sound of police sirens reverberating in my head over and over, and me shooting my piece and running and running...
Cut to-morning-me waking up in a city construction site basement with blood running down my face and me having no idea how I got there or what had happened.
Cut to- interior of car with my older heavyset sister wearing curlers on her head and a big coat over a mumu gripping about how it was 5:30am in the morning and why couldnt i call a taxi to get home (I lost all my cash/wallet,) why did i have to call and wake her up to come and get me, why was there blood on my face, was I hurt, etc. etc.
Cut to- me alone in the kitchen- breakfast time with the morning news on tv, adding bacon to the hot skillet in time to hear the lady newscaster report..."A gun battle ensued last night downtown, 2 men where shot and are in stable condition after a fight broke out between 3 men in front of a nightclub. Patrons ran for cover and police where on the scene on minutes with guns blasting and where able to subdue the situation but one man escaped and is still on the run."
Cut to- Me staring at the tv in shock and the bacon burning in the skillet............."


(Disclaimer-This is a work of fiction. Any names or characters, businesses or places, events or incidents, are fictitious. Any resemblance to actual persons, living or dead, or actual events is purely coincidental.)

But what a night it was lol. and Ill never ever eat sugar of any type or sort when I drinking tequila .