Hey bro, first off b12 has never been scientifically proven to do anything for your appetite...BUT it is cheap enough so that placebo effect is well worth it! second, you can mix it in with your gear, but if you dont have to (not too much pain) I wouldnt...the higher concentration of hormone you're injecting the better...you will get higher peak levels and also sustain those levels for a a longer period of time...well worth it if you can deal with the pain...