NAC causes pulmonary arterial hypertension

heyjack

New member
Interesting article I found...basically Dr. Ben Gaston did a study on mice with NAC. NAC produces nitrosothiol which makes your body think there is an O2 shortage. Therefore the blood vessels constrict in order to make sure the O2 is pumped throughout the body to prevent hypoxia. The arteries in the lungs constrict as well, causing arterial hypertension and hypertrophy of the atrial myocardium.

Anyone ever heard of this? I had planned on taking NAC and liv.52 ds on my next cycle, but this has me second guessing.

S-Nitrosothiols signal hypoxia-mimetic vascular pathology
 
Your not a mouse.

In general, you should ignore all mice/rat/animal studies since they aren't applicable until the same thing is tested in humans.
Animal studies are interesting, but thats about it :)
 
Check the doses too. I only skimmed, but 10mg/mL in the drinking water for an animal that's several magnitudes smaller really skews results when trying to compare.
 
Check the doses too. I only skimmed, but 10mg/mL in the drinking water for an animal that's several magnitudes smaller really skews results when trying to compare.

Yes I couldnt really find a difinative dose (other than what you mentioned) to even begin to translate to a HED. Did I miss it ?
Also on a personal experience note NAC doesnt mess with my BP. I am a bit obsessive about checking it, always have been on cycle. If there was any diff since I started using it it was negligible. Now with low dose daily cia my on cycle BP is better than it has been in years, which is great.
 
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Yes I couldnt really find a difinative dose (other than what you mentioned) to even begin to translate to a HED. Did I miss it ?
Also on a personal experience note NAC doesnt mess with my BP. I am a bit obsessive about checking it, always have been on cycle. If there was any diff since I started using it it was negligible. Now with low dose daily cia my on cycle BP is better than it has been in years, which is great.

Nope, went through it again, they only give the concentration. Although they do say this in the conclusion:
It is reassuring that the NAC dose that caused PAH in mice was higher than the hypoxia-mimetic dose used in humans (48). However, PAH can be subclinical, even presenting as a terminal event (7,*8). In this context, it is noteworthy that NAC treatment may fail to decrease mortality in human clinical trials, despite beneficial antiinflammatory and antioxidant effects (30): PAH has not previously been considered as a NAC toxicity. Surveillance for this toxicity may be appropriate for long-term human trials with NAC.

I'm going to guess it was a huge dose, based on the context.
 
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