New Meta-Analysis finds no link between TRT and increased Cardiovascular Risk

[TRTnooby]

http://www.mayoclinicproceedings.org/article/S0025-6196(14)00925-2/abstract

Abstract
Two recent studies raised new concerns regarding cardiovascular (CV) risks with testosterone (T) therapy. This article reviews those studies as well as the extensive literature on T and CV risks. A MEDLINE search was performed for the years 1940 to August 2014 using the following key words: testosterone, androgens, human, male, cardiovascular, stroke, cerebrovascular accident, myocardial infarction, heart attack, death, and mortality. The weight and direction of evidence was evaluated and level of evidence (LOE) assigned. Only 4 articles were identified that suggested increased CV risks with T prescriptions: 2 retrospective analyses with serious methodological limitations, 1 placebo-controlled trial with few major adverse cardiac events, and 1 meta-analysis that included questionable studies and events. In contrast, several dozen studies have reported a beneficial effect of normal T levels on CV risks and mortality. Mortality and incident coronary artery disease are inversely associated with serum T concentrations (LOE IIa), as is severity of coronary artery disease (LOE IIa). Testosterone therapy is associated with reduced obesity, fat mass, and waist circumference (LOE Ib) and also improves glycemic control (LOE IIa). Mortality was reduced with T therapy in 2 retrospective studies. Several RCTs in men with coronary artery disease or heart failure reported improved function in men who received T compared with placebo. The largest meta-analysis to date revealed no increase in CV risks in men who received T and reduced CV risk among those with ********* disease. In summary, there is no convincing evidence of increased CV risks with T therapy. On the contrary, there appears to be a strong beneficial relationship between normal T and CV health that has not yet been widely appreciated.

 

[Jimstigator]

Nice!

 

[halfwit]

Damn good find! +rep

I love showing stuff like this to my anti-trt endo. Drives her up a wall! Muwahaha.

 

[carverelli]

and my gp doc wants my levels down around 300. makes me want to rage and unleash the animal inside me?

 

[Megatron28]

I sent it to a few Haters out there.

 

[TRTnooby]

I'm sure the T haters will dummy up some new allegations and run a shoddy trial to support it. They're almost as bad as the Vaccine Deniers.

 

[Alpin]

Damn good find! +rep

I love showing stuff like this to my anti-trt endo. Drives her up a wall! Muwahaha.

She's only anti TRT cause her business also involves treating diabetes, thyroid problems etc. Now with disorders like that on the rise why would she care treating hypogonadism?
Alot if endos don't respect hypogonadism and its symptoms.
That study last fall was a gift to many of these anti TRT tyoe docs. They could use that as an excuse to get any hypogonadal patient out of the doors.

 

[halfwit]

She's only anti TRT cause her business also involves treating diabetes, thyroid problems etc. Now with disorders like that on the rise why would she care treating hypogonadism?
Alot if endos don't respect hypogonadism and its symptoms.
That study last fall was a gift to many of these anti TRT tyoe docs. They could use that as an excuse to get any hypogonadal patient out of the doors.

Not in this case, but yes - I completely agree that it is far more profitable to treat symptoms than the cause.