never used NO shotgun, but it's prob like any other no product and I don't think it should hurt taking them together, but I'm not a doc and don't know anything about no shot. be careful with lipodrene, it works good, but sides can be crazy. peel the label off and read all the possible sides - I had them all at the same time - shaky, dizzy, nauseau, felt faint, etc - couldn't work out, had to come home, then I quit taking it. However, I was taking more than the sugg dose and it didn't happen until several days of taking it. I would stick with 1 or 2 caps a day. good luck
