In men, no statistically significant differences from placebo in change from baseline values for free testosterone, DHT, estradiol, follicle-stimulating hormone (FSH), or LH were observed at any GTx-024 dose tested. However, sex hormone-binding globulin (SHBG) was significantly reduced with GTx-024 3 mg versus placebo. The decrease in SHBG was accompanied by a reduction of serum total testosterone in subjects treated with 1 mg or 3 mg of GTx-024 compared to placebo. This data demonstrates that Ostarine is total testosterone suppressive but free testosterone, LH and FSH were not statistically suppressed. Higher doses are likely more suppressive.