I self-injected for the first time today. After three years of weekly visits to my doc for shots, I finally got a script. I have pinned B12 in the past, so I am familiar with the process. Of course, injecting a low viscosity serum vs cyp is a different experience. And so was the immediate reaction I got. I remember after the first injection years ago I got an immediate rush and even a faint taste in my mouth. Since then I have had weekly injections only in the delts without that sensation. Today, I self-injected in the right quad. And had the same sensation - a rush and slight taste. Certainly not unpleasant. I am wondering if the body adapts to an alternate injection site and then responds differently. Or if injecting in a large muscle group (quad) causes a different reaction. Anyone else?