Stomach or Legs

[J-Roberts-77]

Which area to inject that is less painful?

 

[MoparMuscle]

Its intermuscle so.... Glutes or vetro is painless. Shoulders is pretty painless. I don't like quads but it's ok and good to keep in the rotation.

Spotinjections.com has lots of pics for diff spots.

 

[JOWS6]

It's "intramuscular," Mopar. It's funny that this thread was created because I was going to have a discussion on the same subject. I jus' have to sort out all my research info because I can't find what I want to quote.

Basically, subcutaneous injections (below the skin into the fat) has a better effect in patients undergoing testosterone replacement therapy (TRT) according to this study. Interestingly, there was a higher QOL (quality of life) rating among subcutaneous injectors as well. They also found that testosterone levels were much more steadier in this method as opposed to intramuscular injections.

I'm thinking about giving this a shot. No pun intended!

 

[MoparMuscle]

I've read both ways for subq (can't remember what studies). Doesn't it increase estro in some individuals over IM injections?

If you try it I'd love to see a thread with updates and bloods before, and during.

 

[JOWS6]

I've read both ways for subq (can't remember what studies). Doesn't it increase estro in some individuals over IM injections?

If you try it I'd love to see a thread with updates and bloods before, and during.

I don't remember reading about an increase in estrogen. If it does provide for a steadier level of testosterone that would mean a less incidence of aromatization of estrogen.

 

[MoparMuscle]

Study here says blood levels were stable but not that they were more stable then IM, does your study compare the two? I'd like to see it.

This study was done using 1 injection per week - The mean subcutaneous weekly testosterone dose was 55 +/- 27mg with a minimum of 25mg and a maximum of 100mg

No measurements of E2 were done

Question - are there ANY other studies investigating sub q testosterone injections - other than this one


STABLE TESTOSTERONE LEVELS ACHIEVED WITH SUBCUTANEOUS TESTOSTERONE INJECTIONS

M.B. Greenspan, C.M. Chang
Division of Urology, Department of Surgery, McMaster University,
Hamilton, ON, Canada

Objectives: The preferred technique of androgen replacement has been intramuscular (IM) testosterone, but wide variations in testosterone levels are often seen. Subcutaneous (SC) testosterone injection is a novel approach; however, its physiological effects are unclear. We therefore investigated the sustainability of stable testosterone levels using SC therapy. Patients and methods: Between May and September 2005, we conducted a small pilot study involving 10 male patients with symptomatic late-onset hypogonadism.

Every patient had been stable on TE 200 mg IM for 1 year. Patients were instructed to self-inject with testosterone enanthate (TE) 100 mg SC (DELATESTRYL 200 mg/cc, Theramed Corp, Canada) into the anterior abdomen once weekly. Some patients were down-titrated to 50 mg based on their total testosterone (T) at 4 weeks.

Informed consent was obtained as SC testosterone administration is not officially approved by Health Canada. T levels were measured before and 24 hours after injection during weeks 1, 2, 3, and 4, and 96 hours after injection in week 6 and 8.

At week 12, PSA, CBC, and T levels were measured however; the week 12 data are still being collected.

Results: Prior to initiation of SC therapy, T was 19.14+3.48 nmol/l, hemoglobin 15.8+1.3 g/dl, hematocrit 0.47+0.02, and PSA 1.05+0.65 ng/ml. During the first 4 weeks, there was a steady increase in pre-injection T from 19.14+3.48 to 23.89+9.15 nmol/l (p¼0.1). However, after 8 weeks the post-injection T (25.77+7.67 nmol/l) remained similar to that of week 1 (27.46+12.91 nmol/l). Patients tolerated this therapy with no adverse effects.

Conclusions: A once-week SC injection of 50***8211;100 mg of TE appears to achieve sustainable and stable levels of physiological T. This technique offers fewer physician visits and the use of smaller quantity of medication, thus lower costs. However, the long term clinical and physiological effects of this therapy need further evaluation.

No E2? I'd be interested in seeing this with E2 bloods also, maybe with prior historical blood work without an Aromatase inhibitor (AI) with IM injections then with subq and no AI.

 

[MoparMuscle]

That was just the first one I found, I found 1 other but could not view it.

Some dudes personal opinion but his thoughts sounds reasonable:

The real problem is the issues of both absorption as well as estrogen conversion. And note that the whole premise behind esterfication is to increase fatty solubility thus sustaining the realease period for the actual T molecule. If you consider the circulatory interaction of adipose tissue with respect for fat metabolism, do you really want to put the stuff straight into storage.?

The big question seems to be e2 levels but his statement that it would "just sit there" seems to make sense with the slower absorption and stable blood levels (a positive).

 

[mfpd]

To the original question, I inject quads and have my wife inject my glutes. Both are virtually painless. I just rotate clockwise with every injection - left quad, right quad, right glute, left glute. I have yet to try delts or any other location.

 

[Natehayes]

I've been thinking about trying this. Kinda seesm like a lot of oil to be putting right under your skin. I know some guys have reported noticeable lumps that took some time to disappear.

If I do give it a shot, I'll report back here.