No problem brother.
In our study, administration of both tes-tosterone and bicuculline increased escape latency and travel distance as compared to the DMSO+saline Group. It has been shown that there are important reciprocal relationships between brain steroid hormone systems and neurotransmitter systems such as GABAergic, serotonergic and glutaminergic.24,29,30 Sex steroids can rapidly influence neural activity by increasing binding affinity of neuro-transmitters or directly altering cell mem-brane ion conductance in brain structures including the hippocampus.8,29,31 Progestrone, androstenedione, and testosterone retain some modulatory activity on the GABAA receptor.33 Positive modulators of the GABAA receptor produce amnesia,47 suggesting that excessive inhibitory tone could contribute to cognitive impairments, associated with aging. This hypothesis is consistent with the increased activity of glutamic acid decarboxylase in the brains of aged animals,19 and the reduced desensitization of GABAA receptor in neurons from aged rats.46 Our present data which indicate the impairment of spatial performance may be explained by the effect of testosterone on the other GABA receptors such as B and C receptors, which are not affected by bicuculline.23 Since there were no significant differences between the vehicle and experimental group in the swim speed on the fifth day of training in visible platform, performance, it can be inferred that the changes observed could not be attributed to alterations of non-mnemonic factors such as motivational, or sensory processes induced by the treatments. To conclude, the results showed that administration of testosterone and bicuculline used separately impaired spatial learning and memory. Microinjection of bicuculline after testosterone treatment did not alter the spatial learning impairment when compared to the two used separately.
Interaction Between Testosterone and Bicuculline GABAA Antagonist in the CA1 Region of Hippocampus in Spatial Learning in Adult Male Rats - International Journal of Endocrinology and Metabolism - 2008 - Kowsar
IMT now offers the metagenics nutraceutical line. These are prescription grade supplements that can only be obtained through a physician, all of there products are tested and there are no proprietary blends.
Here are the 2 I would rec to offset what they are talking about in the study.
Trancor
Supports a sense of tranquility by modulating the balance between glutamate and GABA with N-acetylcysteine (NAC), green tea catechins, and vitamin B6.*
Taurine and EGCG may enhance the metabolism of GABA.*
Supports relaxation and a sense of calm with magnesium and vitamin B6.*
Designed to act centrally within the brain, this formula features the amino acids NAC and taurine which research suggests may be able to cross the blood-brain barrier.*
Lumina
Dopamine, GABA, and norepinephrine metabolism are implicated in brain functions, such as focus, attention, motivation, learning, and memory.*
Features LactiumPure®, a patented, bioactive decapeptide shown to support relaxation and a healthy stress response, possibly by influencing GABA.*
Provides theanine and DHA, which preliminary research suggests may positively influence the metabolism of neurotransmitters, such as dopamine, GABA, and norepinephrine.*
Designed to act centrally within the brain, this formula features DHA and LactiumPure which research suggests are able to cross the blood-brain barrier along with theanine for targeted neurological support.*
