Testosterone No Longer Working

[mbmiles88]

Hi, I am a 23 year old male currently on testosterone replacement therapy since last fall. The reason I started therapy is because my testosterone level was pretty low for someone my age it was around 300. I go to a testosterone clinic to get this done, and they started me at around 100mg per week and have been gradually increasing the dose ever since. After getting 200mg per week, I finally started seeing a positive difference in my mood, energy, libido, etc and my T level increased to around 550. Although this was an improvement, I still wanted to see higher so I asked to increase the dosage to 220mg per week. After a few weeks of this though, I am starting to not even feel the testosterone effects anymore and I have very low energy and feel almost as bad as I did before the therapy. Does this make any sense at all?

 

[jomamma007]

edit....

 

[jomamma007]

Yeah. It seems you are taking 220mgs in one injection and then having your blood work done the day of your next injection.
Both of these are terrible ideas.
Your estrogen's probably over the roof a day or two after your injection. This is when you need to test your hormones.
You also need to split up your injections into twice a week. Once every 7 days for most is asking for trouble. Personally, on the 6th day after an injection my levels go from 1000 to around 300...

 

[Daniel_IMT_Staff]

Hello,

Just like with any drug, if there is an excessive stimuli the body will adapt to that stimuli and create a sort of tolerance. Normally you will not see any tolerance from T but that is when it is kept in the normal range. You are probably using too much testosterone at 220mg/week.

As jomamma states it would be best to split the injection to twice a week for stable levels. Get full labs done as well so you have a better understanding of your hormone profile. When was the labs done in regards to your injection?

 

[STAUNCHED427]

I put my bottom dollar it is due to injection frequency and lack of e2 control. You never mentioned an AI?

What is your current TRT protocol (doses, freqency)?

Generally speaking, the case for myself and most others, keeping injection frequency to no more than E5D as it keeps levels stable, I suggest and do twice per week for ease and an AI, most commonly Arimidex to keep estrogen controlled.

A TRT protocol is peanuts without proper e2 control and incorrect T dosing/timing.

 

[mbmiles88]

I put my bottom dollar it is due to injection frequency and lack of e2 control. You never mentioned an AI?

What is your current TRT protocol (doses, freqency)?

Generally speaking, the case for myself and most others, keeping injection frequency to no more than E5D as it keeps levels stable, I suggest and do twice per week for ease and an AI, most commonly Arimidex to keep estrogen controlled.

A TRT protocol is peanuts without proper e2 control and incorrect T dosing/timing.

Thanks, I have been getting 220mg once weekly. The clinic I go to refused to do injections twice weekly. I was trying to avoid adding Arimidex because my E2 level was not that high, it was only at 50.

 

[mbmiles88]

I'm going to go ahead and get fresh bloodwork done, is there a way to get this done cheaply somewhere because my doctor only does it every three months? Also, when is the best time to get bloodwork done?

 

[Megatron28]

Private MD - Buy Lab Tests Online. The cheapest option is the Hormone Panel for Females (for men too). Better is the Hormone Panel for Males as itincludes the Estradiol sensitive assay among other things.

Best to to check would be getting both peak and trough levels relative to when you inject.

 

[MBB]

Thanks, I have been getting 220mg once weekly. The clinic I go to refused to do injections twice weekly. I was trying to avoid adding Arimidex because my E2 level was not that high, it was only at 50.

I'm assuming E2 is 'only 50' at your trough when your getting your nest shot, that would mean that your E2 at peak would be likely through the roof. No wonder your feeling lousy again.
It might be time to find a new doc/clinic that'll let you self-inject.

 

[STAUNCHED427]

Refused to do 2x weekly injections? WTF is this.

I'd try find another clinic or take it into your own hands, try let them self inject and get an RC AI.

 

[STAUNCHED427]

Refused to do 2x weekly injections? WTF is this.

I'd try find another clinic or take it into your own hands, try let them self inject and get an RC AI.

 

[klimentiy]

Test E twice a week no less... Its half-life requires you to

 

[villan]

needs to be 2x injects per week

 

[IMT staff]

Sometimes a round of glutathione injections will help this, it is a strong antioxidant