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<h1>VELCADE</h1><p> VELCADE (bortezomib) for Injection is an antineoplastic agent available for intravenous
injection (IV) use only. Each single use vial contains 3.5 mg of bortezomib as a sterile
lyophilized powder. Inactive ingredient: 35 mg mannitol, USP.
Bortezomib is a modified dipeptidyl boronic acid. The product is provided as a mannitol boronic
ester which, in reconstituted form, consists of the mannitol ester in equilibrium with its
hydrolysis product, the monomeric boronic acid. The drug substance exists in its cyclic
anhydride form as a trimeric boroxine.</p>