3rd Week of TRT...Feel tired and unmotivated.......

Alpin

Alpin

New member
I donated blood last Thursday. Next day I noticed my energy go down substantially and just feel like laying down.
I was doing great for the first 2 weeks being on testosterone replacement therapy (TRT), now entering my third week and feel kinda crabby, tired, e.t.c.
Libido is down too...
160 mg/7 days.
Shot was on Sunday.
I'm thinking I went in too soon to donate blood???
Going in for the donation...My HCT was 43 % with Hemo at 14.8....
I've heard HCT comes down 3% after donation and Hemo by 10 %...
Went for a run on Sunday and could barely finish...was out of breath and tired....came home and lay down for hours...
wtf ????
 
What's your E2 at? Also, I'd take a good hard look at your diet. Testosterone helps your metabolism; so what calories you were able to get by with low T may not be sufficient to help your body repair the damage from being hypogonadal AND allowing you to do your daily routines. ;)
 
I don't know yet on E2 levels...waiting for labs. But if they were high doc would call.
Running Human Chorionic Gonadotropin (HCG) at 360 i.u. EOD maybe move it to E3D...
Taking ADEX 0.25 mg EOD....E2 should be controlled to some extent I'm thinking.
My first experience with testosterone replacement therapy (TRT) for 2.5 yrs (before coming on again) did not include HCG...
Maybe the addition of the 2 are elevating E2 ?
Feel low libido and kinda down today....
Felt the brunt of the tiredness come on last Friday after blood donation.
Shot of T was on sunday 160 mg and Human Chorionic Gonadotropin (HCG) 360 i.u. was Monday...(next day) FYI
 
halfwit said:
What's your E2 at? Also, I'd take a good hard look at your diet. Testosterone helps your metabolism; so what calories you were able to get by with low T may not be sufficient to help your body repair the damage from being hypogonadal AND allowing you to do your daily routines. ;)
Click to expand...

x2.....I would think e2 has something to do with it, I have also noticed since being on testosterone replacement therapy (TRT) that I need far more calories.
 
Estrogen could be a little high with the HCG. Wait on blood tests for that before you change anything up. Have you had your thyroid hormones checked?
 
halfwit said:
What's your E2 at? Also, I'd take a good hard look at your diet. Testosterone helps your metabolism; so what calories you were able to get by with low T may not be sufficient to help your body repair the damage from being hypogonadal AND allowing you to do your daily routines. ;)
Click to expand...

Took another 0.25 mg ADEX after reading your post...
after an hour I felt way better.
It's E2...
Cause I took the shot on Sunday(all of the 160 mg) then the next day it was 360 i.u. HCG....took 0.25 mg ADEX too on Sunday.
I only took the ADEX E3D last week...so that was 2 doses.
I need it EOD and probably a bit more I'm thinking...
But I'll just use the 0.25 mg EOD and not deviate away from it.
 
APOLLON said:
thanks feel better now....
took ADEX 1/4 tab earlier.
Click to expand...

My money is on your E2 being too low on that adex dose while doing test cyp. You can't take the same Aromatase inhibitor (AI) dose you were using before testosterone replacement therapy (TRT) for mono-therapy. It works differently when you are getting your test exogenously. You have changed the feedback loop in the HPTA by adding test cyp. I think you are taking too much Aromatase inhibitor (AI) for your current protocol.

I hope you prove me wrong with good labs, but I am concerned for you.
 
Megatron28 said:
My money is on your E2 being too low on that adex dose while doing test cyp. You can't take the same Aromatase inhibitor (AI) dose you were using before testosterone replacement therapy (TRT) for mono-therapy. It works differently when you are getting your test exogenously. You have changed the feedback loop in the HPTA by adding test cyp. I think you are taking too much Aromatase inhibitor (AI) for your current protocol.

I hope you prove me wrong with good labs, but I am concerned for you.
Click to expand...
I'd like to see labs too, but Human Chorionic Gonadotropin (HCG) and test do elevate E2 pretty well, especially if there's any appreciable amount of body fat in the adipose region. At least that's my understanding of it. :)
 
halfwit said:
I'd like to see labs too, but Human Chorionic Gonadotropin (HCG) and test do elevate E2 pretty well, especially if there's any appreciable amount of body fat in the adipose region. At least that's my understanding of it. :)
Click to expand...

Mine understanding too normally. But considering he is on 160mg/week of test, HCG, and only 3 weeks into therapy; I suspect E2 hasn't had time to rear it's ugly head yet. And taking .25mg of adex EOD would really suppress any aromatization that might be occurring in the 3 weeks he has been on testosterone replacement therapy (TRT).

Most guys don't take that much Aromatase inhibitor (AI) on testosterone replacement therapy (TRT). Look at you... at 250mg of test cyp you are only taking .50mg of adex a week. :-)

And remember he's taking the same adex dose now as when he was doing adex-monotherapy which kept the HPTA feedback loop open.

Just a theory (based on what I have seen some other guys go through). I could be wrong. Labs will tell.
 
halfwit said:
I'd like to see labs too, but Human Chorionic Gonadotropin (HCG) and test do elevate E2 pretty well, especially if there's any appreciable amount of body fat in the adipose region. At least that's my understanding of it. :)
Click to expand...

There is some body fat...but things have been improving. I was 295 lbs in June and now 276 lbs.
Looking at old labs here on Human Chorionic Gonadotropin (HCG) mono therapy(350 i.u. 3 times a week) with 0.25 mg ADEX my E2 would be 95 pmol/L
My Free Test was not anywhere near 95 pmol/L.
 
Megatron28 said:
My money is on your E2 being too low on that adex dose while doing test cyp. You can't take the same Aromatase inhibitor (AI) dose you were using before testosterone replacement therapy (TRT) for mono-therapy. It works differently when you are getting your test exogenously. You have changed the feedback loop in the HPTA by adding test cyp. I think you are taking too much Aromatase inhibitor (AI) for your current protocol.

I hope you prove me wrong with good labs, but I am concerned for you.
Click to expand...

Concerned how?
 
Megatron28 said:
Mine understanding too normally. But considering he is on 160mg/week of test, HCG, and only 3 weeks into therapy; I suspect E2 hasn't had time to rear it's ugly head yet. And taking .25mg of adex EOD would really suppress any aromatization that might be occurring in the 3 weeks he has been on testosterone replacement therapy (TRT).

Most guys don't take that much Aromatase inhibitor (AI) on testosterone replacement therapy (TRT). Look at you... at 250mg of test cyp you are only taking .50mg of adex a week. :-)

And remember he's taking the same adex dose now as when he was doing adex-monotherapy which kept the HPTA feedback loop open.

Just a theory (based on what I have seen some other guys go through). I could be wrong. Labs will tell.
Click to expand...

I like it when you speak sense Megatron. It's a damn shame what Optimus did to you in the last movie. :p Although, I would suspect that his E2 levels should be better off at 160mg/wk than what he was producing endogenously. If his adex dose for monotherapy didn't crush his E2, I doubt that (unless he has a problem with his feedback loop; dumping excess estrogen into his system) he'd totally crush it if at the same dose. Then again, .25mg EOD is a tad high for that dose of test.

I would really like to see labs as well.

Apollon: (Sorry, didn't feel like doing a multi-quote :p) How tall are you? Even better, what is your body fat percentage? I have a feeling you might be on the higher end of aromatization and would love to be confirmed by your lab work. :)

Just a hunch given monotherapy didn't completely jackhammer your estradiol into the ground...
 
Luca17 said:
How do I start a new discussion ??
Click to expand...
With this:
0eL7hR9.png
 
halfwit said:
I like it when you speak sense Megatron. It's a damn shame what Optimus did to you in the last movie. :p Although, I would suspect that his E2 levels should be better off at 160mg/wk than what he was producing endogenously. If his adex dose for monotherapy didn't crush his E2, I doubt that (unless he has a problem with his feedback loop; dumping excess estrogen into his system) he'd totally crush it if at the same dose. Then again, .25mg EOD is a tad high for that dose of test.

I would really like to see labs as well.

Apollon: (Sorry, didn't feel like doing a multi-quote :p) How tall are you? Even better, what is your body fat percentage? I have a feeling you might be on the higher end of aromatization and would love to be confirmed by your lab work. :)

Just a hunch given monotherapy didn't completely jackhammer your estradiol into the ground...
Click to expand...

My E2 with 0.25 mg ADEX Mono protocol E3D was 75 pmol/L
In pg/ml it is 20.43
Range <157 pmol/L
 
halfwit said:
That seriously blows my mind. Was it pharmaceutical grade adex or RC? When's your next blood draw? :D
Click to expand...

pharma grade...
looking on a recent blood work(last month before TRT) when it was dosed EOD at 0.25 mg mono protocol has it at <46 pmol/L
 
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