Here is my experience. I used adex for years. Liked it. Exemestane became pretty popular so I really looked into it. I liked the safety profile of it, I like the way it worked (comparing type 1 to type 2 ai's). I switched to stane. It took quite a while to dial in my dosage and frequency of administration. I ended up needing more of it and to take it more often than I thought. It was to the point I almost gave up on it and just went back to dex. Based on my bloodwork y lipids etc really are around the same as dex, slightly better but insginificant. If I was succcessfully taking dex - I would not switch. If I was just starting with an ai - Id try stane. It is very forgiving. Its hard to crash your e2 with stane, not with dex. I like that. For me I needed to dose it daily to manage my e2 I also needed more than people say. I often think that people that say oh on a 500mg/week test cyce 12.5 mg stane eod is where they are or some even less than that there is no way they are basing this off of blood work. I based my dosing off of blood work and I need 25mg/day at that dose of test man. It just isnt as powerful in males as people think. I would dose it daily no matter how low I went in dosing so for trt even if you took like 6.25mg/day fine but Id take it daily, not eod. Eod was a roller coaster for me.