Blood work in. Help! What's my next step?

[hiram1st]

3 months of 100mg E7D Peak and Trough both test at labcorp​

10/31 trough 7 days after last injection



Testosterone, Serum 516 348-1197 ng/dL 01

Estradiol
Estradiol 33.5 7.6-42.6 pg/mL 01

E2 sensitive results:

Estradiol, Sensitive 9 3-70 pg/mL



11/14 Peak 32hours after injection



Testosterone, Serum
Testosterone, Serum 760 348-1197 ng/dL

Estradiol
Estradiol 21.0 7.6-42.6 pg/mL 01


Estradiol, Sensitive
Estradiol, Sensitive 6 3-70 pg/mL

I feel pretty good but from what I read my e2 sensitive should be higher. If this is crashed estrogen it isn't affecting me much.

Before trying to get DR to raise protocol would it be worth trying 50 mg every 3.5 days?

I go for blood work for him in December

 

[babyface58]

Looks like you could increase your dose a bit to get you up to 900+ at your peak then your trough won't be so low. That would probably raise your e2 as well.

 

[TRTnooby]

You could go higher, but if you feel good why mess with it? The numbers are in range. Going every 3.5 or E3D will definitely tighten up the range.

Do you know your SHBG number? Mine is on the lower end, though not out of range, and I feel better with a tighter range. I've heard people with more SHBG feel better with a higher dose less frequently.

 

[Megatron28]

How much AI are you taking? Your E2 is too low.

 

[hiram1st]

No AI. Rolax was being taken during the peak draw for possible gyno issue.

 

[Alpin]

Up to 70 pg/ml sensitive Estradiol is normal?
I just go by the regular assay. Sensitive is not available anyway here.

 

[Megatron28]

No AI. Rolax was being taken during the peak draw for possible gyno issue.

You need to increase your test dose then and/or add hCG.

 

[hiram1st]

Up to 70 pg/ml sensitive Estradiol is normal?
I just go by the regular assay. Sensitive is not available anyway here.

That's what it says on the lab work. I will discuss uping my dosage next visit thank you.

 

[hiram1st]

You need to increase your test dose then and/or add hCG.

Thank you. Will discuss at next visit with dr.

 

[hiram1st]

On both tests both regular and sensitive E 2's were lower on the peak and the trough and the TT was higher on the peak than on the trough isn't t g at backwards?

With more test to aromatise shouldn't the peak e2's be higher than the troughs?

 

[hiram1st]

Looks like you could increase your dose a bit to get you up to 900+ at your peak then your trough won't be so low. That would probably raise your e2 as well.

Ok going to discuss with dr. on next visit thanks

 

[hiram1st]

Do you know your SHBG number?QUOTE]

I all the blood work I've had since starting this journey I don't have a SHBG (Sex hormone-binding globulin) Do I need to specifically request that one?

Havn't seen much on it in discussions on dialing TRT. I will look into that.

Thanks

 

[TRTnooby]

Do you know your SHBG number?QUOTE]

I all the blood work I've had since starting this journey I don't have a SHBG (Sex hormone-binding globulin) Do I need to specifically request that one?

Havn't seen much on it in discussions on dialing TRT. I will look into that.

Thanks

Just something I read on Dr. Crisler's board. He thinks people with lower SBGH do better with smaller more frequent doses, and vice versa.

 

[Chiefy]

I agree with Megatron. Your testosterone and/or your hCG dose will need to go up in order to fix this.

I was in a similar situation, so my doctor decided to increase my doses of both medications. I havent had any follow up labs to confirm yet, but I've definitely been feeling better since we made the protocol changes.

I think we can all say with certainty that your E2 isn't going to come up significantly on your current protocol.

 

[hiram1st]

I agree with Megatron. Your testosterone and/or your hCG dose will need to go up in order to fix this.

I was in a similar situation, so my doctor decided to increase my doses of both medications. I havent had any follow up labs to confirm yet, but I've definitely been feeling better since we made the protocol changes.

I think we can all say with certainty that your E2 isn't going to come up significantly on your current protocol.

Don't currently use Hgc but am going to discuss increasing test and possibly adding Hcg.

Could you look at post #10 and give me your insight?

 

[Chiefy]

Don't currently use Hgc but am going to discuss increasing test and possibly adding Hcg.

Could you look at post #10 and give me your insight?

I'm not really sure why you bloodwork looks like that.

If I had to guess, and this is being pulled out of my ass, maybe it takes longer for E2 to go up than it does for testosterone. Perhaps blood levels of testosterone had not yet reached their peak, so E2 didn't have a chance to increase behind it.

 

[hiram1st]

I'm not really sure why you bloodwork looks like that.

If I had to guess, and this is being pulled out of my ass, maybe it takes longer for E2 to go up than it does for testosterone. Perhaps blood levels of testosterone had not yet reached their peak, so E2 didn't have a chance to increase behind it.

Sounds reasonable to me except most of what I read leads me to believe that it's a linear scale meaning as your test hues up the e2 goes up and doesn't seem to be the case here.

Hopefully a veteran Trt guy will chime in


I appriciate your insight

 

[halfwit]

I'm not really sure why you bloodwork looks like that.

If I had to guess, and this is being pulled out of my ass, maybe it takes longer for E2 to go up than it does for testosterone. Perhaps blood levels of testosterone had not yet reached their peak, so E2 didn't have a chance to increase behind it.

Pretty close to what my guess would be. I do know that while an increase of test brings an increase in estradiol, this is done through a metabolic pathway, which can take time to materialize.

I'd be interested in seeing what your E2 levels 96 hours post injection are, as this could explain if my hypothesis is correct or not.

My .02c

Edit: I've yet to see a body process react in a linear fashion. It's almost always logarithmic in nature AFAIK.

 

[Mrrippedzilla]

On both tests both regular and sensitive E 2's were lower on the peak and the trough and the TT was higher on the peak than on the trough isn't t g at backwards?

With more test to aromatise shouldn't the peak e2's be higher than the troughs?

Considering there are only a few cyp450 enzyme reactions separating T from E, e2 should closely parallel serum T levels so I agree that your results are abit weird.
I agree with halfwit that these things rarely turn out to be linear but, having said that, I dont believe these enzyme reactions take that long to be completed either so....

Any other theories?
Its important to remember that fat mass & shbg changes could play a role in reducing the total level of aromatization - this may be something to look into if your dieting or have been monitoring your shbg levels.

But honestly, I dont think there is any solid explanation for this, nor do I think it really matters in the long run so dont get too caught up on it

 

[hiram1st]

Considering there are only a few cyp450 enzyme reactions separating T from E, e2 should closely parallel serum T levels so I agree that your results are abit weird.
I agree with halfwit that these things rarely turn out to be linear but, having said that, I dont believe these enzyme reactions take that long to be completed either so....

Any other theories?
Its important to remember that fat mass & shbg changes could play a role in reducing the total level of aromatization - this may be something to look into if your dieting or have been monitoring your shbg levels.

But honestly, I dont think there is any solid explanation for this, nor do I think it really matters in the long run so dont get too caught up on it

Ok thanks. I am working on diet have went from 273 to 236 from July to today and I would say I'm still carrying high Bf so thus may be the issue.

Next bloodwork I'm going to start monitoring shbg.